Method for preparing o-chloroaniline by adopting microchannel reaction device

Abstract

The invention belongs to the technical field of fine chemical engineering, and relates to a method for preparing o-chloroaniline by adopting liquid-phase catalytic hydrogenation of o-nitrochlorobenzene. A microchannel reaction device is adopted in reaction, and ortho-nitrochlorobenzene, a solvent and a catalyst react with hydrogen by adopting a slurry feeding mode at 50-150 DEGC under the pressure of 0.5-1.2MPa, so as to obtain the o-chloroaniline. The preparation technology of the o-chloroaniline has the advantages that feed is continuous, the reaction condition is flexible to change, mass transfer effect is good, a reactant fully contacts with a catalyst, the side reaction is reduced, and the like.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and relates to a new preparation method of o-chloroaniline, in particular to a preparation method of o-chloroaniline using a microchannel reaction device. Background technique [0002] O-chloroaniline is an important organic chemical raw material and intermediate, which occupies an important position in the chemical and industrial production of dyes, pesticides, medicines, rubber additives, synthetic resins, spices, photographic medicines, etc. Its production is the synthesis of fine chemicals It is an important field, and its synthesis method has also become a research hotspot this year. At present, domestic manufacturers mainly use the hydrogenation method, but new patents have been published on the research on its synthesis method. [0003] CN1660774A Catalysts such as Ru / C, amorphous NiB, Ni-Fe-B, Ni-Co-B, catalyst consumption is 10-20% of raw material consumption, with ethanol as sol...

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Problems solved by technology

[0003]CN1660774A uses catalysts such as Ru / C, amorphous NiB, Ni-Fe-B, Ni-Co-B, etc., and the amount of catalyst is 10-20% of the amount of raw materials , using ethanol as a solvent, the hydrogen obtained by cracking with alcohol is used for hydrogenation reaction, but the amount of catalyst required for the reaction in this patent is very large, which increases the cost

[0007]In organic hydrogenation experiments, the internal specific surface area of ​​conventional reactors is generally about 100m2m-3 , due to uneven heat transfer and mass transfer, so-called "hot spots" will be generated locally, resulting in a decrease in reaction selectivity, catalyst poisoning, and increased side reactions