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Solid sodium sarcosine preparation method

A technology for sodium sarcosinate and sarcosine, applied in the field of carboxyl generation, can solve the problems of high production cost, difficult recovery, low yield and the like, and achieve the effects of reduced requirements, high yield and mild reaction conditions

Pending Publication Date: 2014-03-26
TIANJIN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to solve the problems of high production cost, low yield, difficult recovery and serious pollution in the existing preparation method of sodium sarcosinate, and propose a method for preparing high-purity solid sodium sarcosinate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of solid sodium sarcosinate comprises the steps:

[0026] a. Hydroxyacetonitrile and methylamine are condensed to obtain methylaminoacetonitrile:

[0027] Add hydroxyacetonitrile with a mass fraction of 50% to the reaction vessel, stir, cool with cold water to a temperature less than 10°C, add dropwise a 25% mass fraction of methylamine solution, the molar ratio of hydroxyacetonitrile to methylamine is 1: 1.1. During the dropping process, the temperature is controlled to be less than 15°C. The dropping process lasts for 1 hour. After the dropping is completed, continue to stir for 1 hour to obtain a methylaminoacetonitrile solution;

[0028] b. adding sodium hydroxide to the above-mentioned methylaminoacetonitrile solution at 100°C, the mol ratio of hydroxyacetonitrile and sodium hydroxide is 1:1.463 and hydrolyzed to obtain sodium methylaminoacetate, namely sodium sarcosinate and sodium hydroxide;

[0029] c. add the hydrochloric acid equimolar ...

Embodiment 2

[0034] The preparation method of solid sodium sarcosinate comprises the steps:

[0035] a. Hydroxyacetonitrile and methylamine are condensed to obtain methylaminoacetonitrile:

[0036] Add hydroxyacetonitrile with a mass fraction of 50% to the reaction vessel, stir, cool with cold water to a temperature less than 10°C, add dropwise a 25% mass fraction of methylamine solution, the molar ratio of hydroxyacetonitrile to methylamine is 1: 1.6. During the dropping process, the temperature is controlled to be less than 15°C. The dropping process lasts for 1 hour. After the dropping is completed, continue to stir for 1 hour to obtain a methylaminoacetonitrile solution;

[0037] b. Add sodium hydroxide to the above-mentioned methylaminoacetonitrile solution at 120°C, the mol ratio of hydroxyacetonitrile to sodium hydroxide is 1: 1.563 and hydrolyzed to obtain sodium methylaminoacetate, i.e. a mixed solution of sodium sarcosinate and sodium hydroxide;

[0038] c. add the hydrochloric ...

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Abstract

The invention discloses a high-purity solid sodium sarcosine preparation method. The specific technical scheme comprises the following steps: condensing hydroxyacetonitrile and methylamine to obtain methylaminoacetonitrile; adding sodium hydroxide, and hydrolyzing to obtain sodium methylaminoacetate, namely a sodium sarcosine liquid and free sodium hydroxide mixture; adding hydrochloric acid which is equal to the sodium sarcosine in mol, and neutralizing to obtain a sarcosine and sodium chloride mixture; separating sodium chloride and sarcosine through an electrodialysis membrane separation technology to obtain a high-purity sarcosine solution and an impurity solution; distilling the high-purity sarcosine solution with a multifunctional evaporator to obtain solid crystals, separating to obtain pure sarcosine, and dissolving the sarcosine with 0.5 time of purified water; and dropwisely adding 1:0.98 mol of sodium methoxide at 40 DEG C to precipitate solid sodium sarcosine, performing centrifugal separation to obtain white solids, and drying to obtain the finished product, wherein after the cycle is completed, the mother solution can be recovered through rectifying, and methanol can be for private use or can be sold as a byproduct. The process has peculiar characteristics; and high-purity sodium sarcosine solids can be prepared through the process.

Description

technical field [0001] The invention relates to the field of generating carboxyl groups in amino-containing compounds, in particular to a method for preparing high-purity solid sodium sarcosinate. Background technique [0002] Sodium sarcosinate structural formula: CH 3 NHCH 2 COONa, also known as sodium N-methylglycinate, is a white triangular crystal, easily soluble in water, slightly soluble in ethanol, soluble in water and becomes alkaline, and the pH value of the solution is about 12~13; heated to 210~220 ℃ Most of them lose a molecule of water and decompose, and a small part decomposes into dimethylamine and carbon dioxide. The aqueous solution with a sodium sarcosinate content higher than 40% is easy to polymerize, with a relative density of 1.198 (20 / °C) and a boiling point of 108°C. [0003] Sodium sarcosine is mainly used in the production of creatine monohydrate, N-acyl sarcosine and sodium salt. Creatine can effectively improve muscle strength, speed and endu...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C229/12C07C31/04C07C29/09
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA
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