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Application of rhodamine B based fluorescence sensor

A fluorescent sensor and sensor technology, applied in the direction of fluorescence/phosphorescence, material excitation analysis, etc., can solve the problems of expensive detection and insufficient fast detection, and achieve the effects of high detection sensitivity, high quantum yield, and fast detection speed

Inactive Publication Date: 2014-03-26
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have many disadvantages, such as sample pretreatment, detection is not fast enough, detection is expensive, etc.

Method used

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  • Application of rhodamine B based fluorescence sensor
  • Application of rhodamine B based fluorescence sensor
  • Application of rhodamine B based fluorescence sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] UV-Vis absorption performance test

[0025] 1. UV absorption performance test of different heavy metal ions

[0026] Preparation of ethyl benzyl 3-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthene]-2-yl)propionate Form 10 μmol / L methanol-water mixed solution (4:6, V:V), take 3000 μL and put it in the liquid pool, and measure the ultraviolet absorption value.

[0027] Use a micro-sampler to measure the prepared MgCl 2 ·6H 2 O, SnCl 2 ·H 2 O, CrCl 3 ·6H 2 O , AgNO 3 , CaCl 2 , NaCl, PbCl 2 , KCl, MnCl 2 4H 2 O, ZnCl 2 , CuCl 2 2H 2 O, LiCl H 2 O, Ba(NO 3 ) 2 , HgCl 2 ,, CoCl 2 , FeCl 2 4H 2 O, FeCl 3 ·6H 2 O, CdCl 2 2.5H 2 O, AlCl 3 The plasma solution is added to the liquid pool, and the changes of the ultraviolet absorption spectrum are observed and recorded. found that adding SnCl 2 ·H 2 After O, there is a large absorption value, indicating that it is only sensitive to tin ions, thus proving that tin ions can be specifical...

Embodiment 2

[0031] Fluorescence performance test

[0032] 1. Fluorescence response test to different heavy metal ions

[0033] Preparation of ethyl benzyl 3-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthene]-2-yl)propionate Make a 10 μmol / L methanol-water mixed solution (4:6, V:V), take 3000 μL and place it in the liquid pool to detect its initial fluorescence value.

[0034] Use a micro-sampler to measure the prepared MgCl 2 ·6H 2 O, SnCl 2 ·H 2 O, CrCl 3 ·6H 2 O , AgNO 3 , CaCl 2 , NaCl, PbCl 2 , KCl, MnCl 2 4H 2 O, ZnCl 2 , CuCl 2 2H 2 O, LiCl H 2 O, Ba(NO 3 ) 2 , HgCl 2 ,, CoCl 2 , FeCl 2 4H 2 O, FeCl 3 ·6H 2 O, CdCl 2 2.5H 2 O, AlCl 3 Add the plasma solution to the liquid pool, observe and record the changes in the fluorescence spectrum. found that adding SnCl 2 ·H 2 After O, the fluorescence intensity changes, indicating that only tin ions are sensitive, which further proves that tin ions can be specifically detected. (Such as image 3 s...

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Abstract

The invention discloses an application of a rhodamine B based fluorescence sensor which can specifically detect tin ions. According to the application, benzyl 3-(3', 6'-bis(diethyl amino)-3-oxo-spiro [isoindoline-1, 9'-xanthene]-2-yl) ethyl propionate is taken as a substrate, different heavy metal ions such as MgCl2*6H2O, SnCl2*H2O, CrCl3*6H2O, AgNO3, CaCl2, NaCl, PbCl2, KCl, MnCl2*4H2O, ZnCl2, CuCl2*2H2O, LiCl*H2O, Ba(NO3)2, HgCl2, CoCl2, FeCl2*4H2O, FeCl3*6H2O, CdCl2*2.5H2O, AlCl3 and the like are added, and fluorescent response is found only when SnCl2*H2O is added, so that the fluorescence sensor which can specifically detect tin ions is developed. The sensor has the advantages of high specificity and sensitivity and the like and has important application potentials in the aspects of disease diagnosis and health evaluation.

Description

technical field [0001] The invention relates to an application of a rhodamine B-based fluorescence sensor, in particular to an application of the rhodamine B-based fluorescence sensor to specifically detect tin ions. Background technique [0002] Tin is one of the essential trace elements in the human body. It has an important impact on various physiological activities of the human body and the maintenance of human health. Its main physiological functions are anti-tumor and promotion of protein and nucleic acid synthesis. The lack of tin in the human body will lead to abnormal metabolism of protein and nucleic acid, but people who eat too much tin may experience dizziness, diarrhea, nausea and other adverse symptoms, and may even cause gastroenteritis in severe cases. Excessive tin content will also affect water quality. Therefore, finding a simple and effective method for detecting tin content in the environment and organisms is of great significance for environmental ...

Claims

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Application Information

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IPC IPC(8): G01N21/64
Inventor 包晓峰曹小伟金艳艳刘督亮史加新
Owner NANJING UNIV OF SCI & TECH
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