The invention relates to the technical field of high polymer materials, in particular to an organic silicone adhesive containing a nano-silver material and a preparation method thereof. The organic silicone adhesive is prepared from the following components: vinyl-terminated methyl phenyl polysiloxane, an amine compound, terminal group hydrogen-containing polysiloxane, o-hydroxybenzophenone, nano-silver, a toughening agent, heat-resistant filler, a curing agent and a platinum catalyst, and has an antibacterial function, and is better in durability and long in service life. The preparation method comprises the following steps of weighing vinyl-terminated methyl phenyl polysiloxane, the amine compound, the terminal group hydrogen-containing polysiloxane, the toughening agent and the platinumcatalyst, and adding the materials into a sealed reaction device for heating under the protection of inert gas, adding the nano-silver and the heat-resistant filler, and stirring, then adding o-hydroxybenzophenone and the curing agent, and continuously stirring, decompressing to remove bubbles, and heating and curing to obtain an organic silicone adhesive. The preparation process is simple, the obtained organic silicone adhesive is good in antibacterial effect, and the durability of the organic silicone adhesive is improved.