Medicine preparation used for treating chronic cardiac failure and preparing method thereof

A pharmaceutical preparation and technology for chronic heart failure, applied in the field of traditional Chinese medicine granules for the treatment of chronic heart failure and its preparation, can solve the problems of difficult molding process operation, easy moisture absorption of extract powder, increased dosage, etc., and achieve simple process , improve patient compliance, the effect of less daily dosage

Inactive Publication Date: 2014-04-09
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent ZL 200510024018.6 discloses the preparation method of Lujiaofang (Xinsheng preparation) granules, in which the extract powder is prepared by spray drying; but the inventor of the present application found in subsequent production that the extract powder obtained by spray drying It is very easy to absorb moisture when granulating, and it has strict requirements on the environment during granulation, which makes the operation of the molding process more difficult. A large number of auxiliary materials can solve the above problems, but therefore increased the dosage

Method used

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  • Medicine preparation used for treating chronic cardiac failure and preparing method thereof
  • Medicine preparation used for treating chronic cardiac failure and preparing method thereof
  • Medicine preparation used for treating chronic cardiac failure and preparing method thereof

Examples

Experimental program
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Effect test

experiment example 1

[0038] 1. Conditions of extract powder obtained by different drying methods

[0039] Traditional Chinese medicine extract powder has the characteristics of powder, and its particle size, fluidity, density, hygroscopicity, viscosity and other properties affect the formulation design, process selection and quality of finished products; among them, hygroscopicity, bulk density and fluidity It has a great influence on the compressibility of the powder, the effect of granulation, and the difference in particle loading.

[0040] In the present invention, the vacuum microwave drying and the vacuum drying methods are tested respectively when drying the extract, and compared with the spray drying method.

[0041] Take other raw materials in the formula except deer horn glue and add 10 times the amount of water, extract twice, 0.5 hours each time; combine the extracts, filter, concentrate the filtrate to a relative density of 1.02~1.04 (90°C), let cool, Centrifuge, take the supernatant...

Embodiment 2

[0070] Embodiment 2 Microwave drying prepares extract powder

[0071] Take 6Kg of Epimedium, 6Kg of Ligustrum lucidum, 4Kg of Psoralen, 3Kg of Tangerine Peel, and 3Kg of Cornus officinalis, add water and decoct three times, half an hour each time, add 10 times the amount of water each time, combine the decoction, filter, and concentrate the filtrate to The relative density is about 1.03~1.04 (90°C). Let it cool and centrifuge at high speed. Take the supernatant and concentrate it into an extract with a relative density of about 1.1 (90°C). Put it in a microwave dryer and microwave it at 55°C. Take it out after drying for 60 minutes, pulverize it to obtain extract powder, add deer horn gum powder, mix well to obtain medicinal powder, and dry granulate to obtain compound deer horn granules.

[0072] The HPLC method was used to determine the content of active ingredients and calculate the transfer rate, among which the transfer rate of icariin was 66%, and that of loganin was 60%...

Embodiment 3

[0073] Embodiment 3 Microwave drying prepares extract powder

[0074] Take 5Kg of Epimedium, 6Kg of Ligustrum lucidum, 3Kg of Psoralen, 2Kg of Tangerine Peel, 3Kg of Cornus officinalis, add 10 times the amount of water, decoct for one hour, filter; add 10 times the amount of water to the filter residue, decoct for one hour, filter After that, the secondary filtrate was combined and concentrated to a relative density of about 1.03 (90°C), centrifuged at 16000rps at a high speed, the supernatant was taken and then concentrated to an extract with a relative density of 1.12 (90°C), placed in a microwave dryer, at 50 Microwave drying at ℃ for about 80 minutes, take out and pulverize, add antler gum powder, mix well to obtain medicinal powder, dry granulate to obtain compound antler granules.

[0075] The HPLC method was used to determine the content of active ingredients and calculate the transfer rate, among which the transfer rate of icariin was 65%, and that of loganin was 64%. ...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and relates to a medicine preparation used for treating chronic cardiac failure and a preparing method thereof. According to the method, antler gelatin, epimeddium, glossy privet fruit, psoralea fruit, dogwood fruit and dried orange peel are used as the main raw materials, subjected to microwave drying or vacuum drying to obtain dry extract, and the granulated by utilization of a dry method or a wet method to obtain compound antler granules. The extract powder obtained by the microwave drying method or the vacuum drying method is beneficial to granulation. The amount of auxiliary materials is small and the amount taken a day is small, thus improving patient compliance. In particular, the amount of the auxiliary materials is reduced and the moisture-proof performance of the granules is significantly enhanced at the same time. The rate of finished products of the granules is not less than 90%. The granules have functions of regulating and tonifying yin and yang, warming the spleen and strengthening the heart, and are especially suitable for chronic cardiac failure which is discriminated to belong to deficiency of the kidney by the traditional Chinese medicine. The preparation method is simple in technology, high in production efficiency and low in cost, and is suitable for continuous and automatic production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine for treating chronic heart failure, in particular to a traditional Chinese medicine granule for treating chronic heart failure and a preparation method thereof. Background technique [0002] Chronic heart failure is a pathophysiological state in which abnormal heart function leads to the long-term inability of the heart to pump blood to meet the needs of tissue metabolism. It is a clinical syndrome in which various cardiovascular diseases develop to a severe stage. Chronic heart failure has become a common clinical disease and a frequently-occurring disease, which seriously endangers the health of patients. According to statistics, the 5-year survival rate of patients is similar to that of malignant tumors. At present, Western medicine such as angiotensin-converting enzyme inhibitors, aldosterone inhibitors, and diuretics are o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P9/04A61K35/32
Inventor 刘力徐德生胡婉英张建伟
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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