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Compound preparation containing lutein ester and preparation method thereof

A technology of compound preparation and lutein ester, applied in the field of prevention or treatment of age-related macular degeneration and relief of visual fatigue, compound preparation containing lutein ester and its preparation, can solve the problem of low bioavailability and high processing cost , poor stability and other issues, to achieve high bioavailability, prevent damage, and protect the retina

Active Publication Date: 2014-04-23
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technical scheme adopts lutein etc. as the main functional substances, and its disadvantages are: poor solubility, poor stability, low bioavailability, high processing cost, etc.

Method used

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  • Compound preparation containing lutein ester and preparation method thereof
  • Compound preparation containing lutein ester and preparation method thereof
  • Compound preparation containing lutein ester and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Lutein Ester Capsules Containing Lycopene, Lycium Barbarum Extract and Cassia Seed Powder

[0061] Prescription (based on the total content of each drug 200mg):

[0062]

[0063]

[0064] Preparation:

[0065] Feed lutein esters, lycopene, wolfberry fruit extract, zinc gluconate, vitamin C and starch in the amount of the above prescription in 10000 times, pass through 80 mesh sieves respectively to obtain fine powder, and then mix with cassia seed powder evenly , add starch slurry to make soft material, granulate, dry in an oven at 60°C; then add magnesium stearate (magnesium stearate has passed through an 80-mesh sieve in advance), mix evenly, granulate, and fill into capsules.

Embodiment 2

[0066] Example 2: Lutein Ester Capsules Containing Lycopene, Lycium Barbarum Extract and Cassia Seed Powder

[0067] Prescription (based on the total content of each drug 200mg):

[0068]

[0069] Preparation:

[0070] In this example, sucrose is used as diluent, low-substituted hydroxypropyl cellulose is used as disintegrant, talcum powder is used as glidant, and water is used as binder. Dried in an oven, all the other preparation methods were the same as in Example 1.

Embodiment 3

[0071] Example 3: Lutein Ester Capsules Containing Lycopene, Wolfberry Fruit Extract and Cassia Seed Powder

[0072] Prescription (based on the total content of each drug 200mg):

[0073]

[0074] Preparation:

[0075] In this embodiment, glucose is used as a diluent, sodium carboxymethyl starch is used as a disintegrant, sodium lauryl sulfate is used as a glidant, and ethanol is used as a binder. Dry in an oven at 50°C, and the rest of the preparation method is the same as in Example 1.

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Abstract

The invention provides a compound preparation containing lutein ester, which is taken orally. The compound preparation comprises the following raw materials in parts by weight: 0.3-10.1 parts of lutein, 0-12.2 parts of lycopene, 0.1-18.7 parts of beta-carotene, 0-6.3 parts of vitamin B1, 0-7.2 parts of vitamin B2, 12.6-33.8 parts of vitamin C, 0-10.6 parts of vitamin E, 18.15-42.75 parts of zinc gluconate, 0-126.6 parts of wolfberry extract and 0-89.5 parts of cassia seed powder. The compound preparation containing lutein ester provided by the invention is scientific and reasonable in prescription composition and content collocation, innovative and feasible in process, and both capable of reducing the raw material cost, and greatly improving the bioavailability and biological safety for taking, generating synergistic interaction, significantly preventing and treating AMD disease and helping to alleviate visual fatigue, so that the market application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of medical and health products, and relates to a compound preparation containing lutein ester and a preparation method thereof, which are mainly used in preventing or treating age-related macular degeneration and relieving visual fatigue. Background technique [0002] Eyes are an important organ for people to acquire knowledge, and they are also sensitive organs that are prone to damage. Excessive use of eyes, myopia, hyperopia, astigmatism and neurasthenia will all cause visual fatigue. Visual fatigue will increase the incidence of various eye diseases, such as age-related Macular degeneration, retinal detachment, etc., can lead to blindness in severe cases. [0003] Among them, age-related macular degeneration (age-related macular degeneration, referred to as AMD, also known as age-related macular degeneration), is divided into two types: dry and wet, and is considered to be one of the most difficult eye d...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P27/02A61K31/525A61K31/51A61K31/375A61K31/355A61K31/025A61K31/01A61K31/191
Inventor 马凤森周密方多凤
Owner ZHEJIANG UNIV OF TECH
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