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A compound preparation containing lutein ester and its preparation method

A compound preparation, a technology of lutein ester, applied in the field of medical and health care products, can solve the problems of low bioavailability, high processing cost, poor solubility and the like, and achieve the effects of high bioavailability, preventing damage and protecting the retina

Active Publication Date: 2017-09-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technical scheme adopts lutein etc. as the main functional substances, and its disadvantages are: poor solubility, poor stability, low bioavailability, high processing cost, etc.

Method used

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  • A compound preparation containing lutein ester and its preparation method
  • A compound preparation containing lutein ester and its preparation method
  • A compound preparation containing lutein ester and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Lutein ester capsules containing lycopene, wolfberry extract and cassia seed powder

[0061] Prescription (based on 200mg total component content of each drug):

[0062]

[0063]

[0064] Preparation:

[0065] The above prescription amount of lutein ester, lycopene, wolfberry extract, zinc gluconate, vitamin C and starch are fed in 10,000 times the amount, and they are passed through an 80-mesh sieve to obtain fine powder, which is then mixed with cassia seed powder. , Adding starch slurry to make soft material, granulating, drying in an oven at 60°C; adding magnesium stearate (magnesium stearate has been pre-passed through an 80-mesh sieve), mixing uniformly, sizing, and filling into capsules.

Embodiment 2

[0066] Example 2: Lutein ester capsules containing lycopene, wolfberry extract and cassia powder

[0067] Prescription (based on 200mg total component content of each drug):

[0068]

[0069] Preparation:

[0070] In this example, sucrose was used as diluent, low-substituted hydroxypropyl cellulose was used as disintegrant, talc was used as glidant, and water was used as binder. Each component of the prescription was passed through a 100-mesh sieve and granulated at 70°C. Dry in an oven, and the other preparation methods are the same as in Example 1.

Embodiment 3

[0071] Example 3: Lutein ester capsules containing lycopene, wolfberry extract and cassia seed powder

[0072] Prescription (based on 200mg total component content of each drug):

[0073]

[0074] Preparation:

[0075] In this example, glucose was used as diluent, sodium carboxymethyl starch was used as disintegrant, sodium lauryl sulfate was used as glidant, and ethanol was used as binder. Each component of the prescription was passed through an 80-mesh sieve. Dry in an oven at 50°C, and the other preparation methods are the same as in Example 1.

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Abstract

The invention provides a compound preparation containing lutein ester, which is administered orally. The compound preparation is calculated according to weight components and includes the following raw materials: lutein ester: 0.3-10.1 parts, lycopene: 0-12.2 β-carotene: 0.1-18.7 parts, vitamin B1: 0-6.3 parts, vitamin B2: 0-7.2 parts, vitamin C: 12.6-33.8 parts, vitamin E: 0-10.6 parts, zinc gluconate: 18.15- 42.75 parts, Lycium barbarum extract: 0-126.6 parts, Cassia seed powder: 0-89.5 parts. The compound preparation containing lutein ester provided by the present invention has scientific and reasonable combination of prescription components and contents, and feasible process innovation, which not only reduces the cost of raw materials, but also greatly improves the bioavailability and the biological safety of taking, and can synergize, significantly It can prevent and treat AMD diseases, and assist in alleviating visual fatigue. It has broad market application prospects.

Description

Technical field [0001] The invention belongs to the technical field of medical and health products, and relates to a compound preparation containing lutein esters and a preparation method thereof, and is mainly applied to prevent or treat age-related macular degeneration and relieve visual fatigue. Background technique [0002] The eye is an important organ for people to acquire knowledge, and it is also a sensitive organ that can easily cause damage. Excessive eye use, nearsightedness, hyperopia, astigmatism and neurasthenia can all cause asthenopia. Asthenopia will increase the incidence of various eye diseases, like age-related Macular degeneration, retinal detachment, etc., severe cases can lead to blindness. [0003] Among them, age-related macular degeneration (AMD, also known as age-related macular degeneration) is divided into two types, dry and wet, and is considered to be one of the most refractory eye diseases in the world. The academic circles believe that AMD is cause...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61P27/02A61K31/525A61K31/51A61K31/375A61K31/355A61K31/025A61K31/01A61K31/191
Inventor 马凤森章捷周密方多凤
Owner ZHEJIANG UNIV OF TECH
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