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Medical dressing hydrogel composite fabric as well as preparation method and application thereof

A composite fabric and gel technology, which is applied in medical science, absorbent pads, bandages, etc., can solve problems such as poor mechanical strength and inconvenience, and achieve the effects of avoiding infection, prolonging the action period of drugs, and making the preparation process simple and easy.

Active Publication Date: 2014-04-23
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the defect of poor mechanical strength, and it often needs to be fixed during application, causing inconvenience

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • Medical dressing hydrogel composite fabric as well as preparation method and application thereof
  • Medical dressing hydrogel composite fabric as well as preparation method and application thereof
  • Medical dressing hydrogel composite fabric as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of medicinal dressing hydrogel composite fabric:

[0034] Dissolve 0.4g of ceric ammonium nitrate, 25mL of N-isopropylacrylamide and 1.2g of dimethylformamide in 0.1mol of nitric acid solution, and bubble with nitrogen;

[0035] Weigh 200 mg of cotton cellulose and use 10 mL of cerium ammonium nitrate solution with a concentration of 20 mM to initiate the reaction for 15 minutes, then blot with a paper towel to remove excess cerium ammonium nitrate solution;

[0036]Then, the cotton cellulose that had been initiated the reaction was dissolved in a mixed solution of 5mL N-isopropylacrylamide and dimethylformamide (dissolve 25mL N-isopropylacrylamide and 1.2g of dimethylformamide as a cross-linking agent) After soaking in 0.1M nitric acid) for 30min; spread the cotton cellulose on a dry glass plate, and polymerize the obtained substrate for 48h under nitrogen conditions. After the complete reaction, the product was washed with water to remove the...

Embodiment 2

[0038] Embodiment 2: Preparation of medicinal dressing hydrogel composite fabric:

[0039] Dissolve 0.4g of ceric ammonium nitrate, 25mL of N-isopropylacrylamide and 1.6g of dimethylformamide in 0.1mol of nitric acid solution, and bubble with nitrogen;

[0040] Weigh 200 mg of cotton cellulose and use 10 mL of cerium ammonium nitrate solution with a concentration of 20 mM to initiate the reaction for 15 minutes, then blot with a paper towel to remove excess cerium ammonium nitrate solution;

[0041] Then, the cotton cellulose that had been initiated the reaction was dissolved in a mixed solution of 5mL N-isopropylacrylamide and dimethylformamide (dissolve 25mL N-isopropylacrylamide and 1.2g of dimethylformamide as a cross-linking agent) After soaking in 0.1M nitric acid) for 30min; Cotton cellulose was spread flat on a dry glass plate; The obtained substrate was polymerized for 48h under nitrogen conditions, and the product was washed with water after complete reaction to remo...

Embodiment 3

[0043] Embodiment 3: Preparation of medicinal dressing hydrogel composite fabric:

[0044] Dissolve 0.2g ammonium persulfate, 25mL N-isopropylacrylamide and 1.2g dimethylformamide in 0.1mol nitric acid solution, and bubble with nitrogen;

[0045] Weigh 200 mg of cotton cellulose and use 10 mL of cerium ammonium nitrate solution with a concentration of 20 mM to initiate the reaction for 15 minutes, then blot with a paper towel to remove excess cerium ammonium nitrate solution;

[0046] Then, the cotton cellulose that had been initiated the reaction was dissolved in a mixed solution of 5mL N-isopropylacrylamide and dimethylformamide (dissolve 25mL N-isopropylacrylamide and 1.2g of dimethylformamide as a cross-linking agent) After soaking in 0.1M nitric acid) for 30min; spread the cotton cellulose on a dry glass plate, and polymerize the obtained substrate for 48h under nitrogen conditions. After the complete reaction, the product was washed with water to remove the residue on th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention relates to a medical dressing hydrogel composite fabric as well as a preparation method and an application thereof and belongs to the technical field of a traditional Chinese medicine preparation and a preparation method thereof. The preparation method comprises the following steps: dissolving N-isopropylacrylamide and an initiator by using a solvent and foaming by using nitrogen; carrying out initiation reaction on cotton cellulose in the initiator; soaking the cotton cellulose after the initiation reaction in the mixed solution of N-isopropylacrylamide and dimethylfomamide and then carrying out polymerization reaction in the presence of nitrogen to acquire poly(N-isopropyl acrylamide-cotton cellulose); dissolving poly(N-isopropyl acrylamide-cotton cellulose) together with alginate in distilled water to form hydrosol on the surface, and removing the solvent under low pressure by a rotary evaporator to acquire the medical dressing hydrogel composite fabric. The medical dressing hydrogel composite fabric has the advantages of having high mechanical strength and anti-microbial, anti-infective and hematostatic functions, intelligently controlling humidity to maintain hydrated skin, preventing adhesion of the fabric and cambiums and effectively promoting epithelization and wound healing of tissue cells.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations and preparation methods thereof, in particular to a medicinal dressing hydrogel composite fabric and its preparation method and application, which are mainly used for hemostasis and tissue repair of various acute and chronic wounds. Background technique [0002] Local trauma and the resulting bleeding, infection, and ulcer are common injuries. Improper treatment often causes wound inflammation, suppuration, and even ulcer infection. Traditional methods generally use sterile gauze and topical antibiotics for treatment. Traditional gauze dressings can’t keep the wound moist, hinder the epithelialization of tissue cells, and delay wound healing; dressing fibers are easy to fall off, causing foreign body reactions and affecting healing; Destruction of the new epithelium and granulation tissue causes bleeding, which is not only unfavorable for wound healing, but also ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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IPC IPC(8): A61L15/42A61L15/44A61L15/28C08F251/02C08F220/54C08L51/02C08L5/04C08J3/075
CPCA61L15/28A61L15/44C08B15/06C08F220/54C08F251/02C08L1/08C08L5/04C08L51/02
Inventor 韩晋袁海龙徐和徐平华申宝德
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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