Phospholipid complex of silybum marianum extract and preparation method for phospholipid complex

A technology of phospholipid complexes and extracts, which is applied in the field of medicine, can solve the problems of low oral bioavailability and poor water solubility, and achieve the effect of increasing bioavailability, increasing fat solubility, and rapidly exerting drug effects

Inactive Publication Date: 2014-04-30
江苏健佳药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Milk thistle extracts currently on the market have good fat solubility, poor water solubility, and low oral bioavail

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of milk thistle extract

[0026] After screening the full-grained milk thistle seeds, first remove the oil in them by mechanical pressing to obtain milk thistle seed cakes. Take 500 grams of cakes and add 2000ml of acetone. After soaking for 2 hours, heat to 60 degrees Celsius and extract for 16 hours. Concentrate at 60 degrees Celsius for 6 hours, then dry at 85 degrees Celsius for 1 hour to obtain 48.7 grams of milk thistle extract.

Embodiment 2

[0027] Example 2 Preparation of milk thistle extract phospholipid complex

[0028] 10 grams of the milk thistle extract prepared in Example 1 were dissolved in 200 grams of ethanol to form a solution and ultrasonicated at 400W for 0.5 hours. 40 grams of soybean lecithin was dissolved in 400 grams of ethanol to form a solution and ultrasonicated at 400 W for 0.5 hours.

[0029] Immediately mix the above two solutions and sonicate again at 400W power for 0.5 hours, then heat the sonicated mixed solution at 70°C for 1h, and immediately cool in an ice bath after heating. Evaporate the cooled solution under reduced pressure to recover the organic solvent, and irradiate the mixture under reduced pressure with an infrared lamp for 20 minutes during the reduced-pressure evaporation process. After the solvent is completely evaporated, dry it with air at 45°C to obtain a brown color. Phospholipid complex dry product of milk thistle extract 48.2 grams.

[0030]

Embodiment 3

[0031] Example 3 Preparation of milk thistle extract phospholipid complex

[0032] 10 grams of the milk thistle extract prepared in Example 1 were dissolved in 200 grams of ethanol to form a solution and ultrasonicated at 400W for 0.5 hours. 40 g of phosphatidylcholine was dissolved in 400 g of ethanol to form a solution and sonicated at 400 W for 0.5 hours.

[0033] Immediately mix the above two solutions and sonicate again at 400W power for 0.5 hours, then heat the sonicated mixed solution at 70°C for 1h, and immediately cool in an ice bath after heating. Evaporate the cooled solution under reduced pressure to recover the organic solvent, and irradiate the mixture under reduced pressure with an infrared lamp for 20 minutes during the reduced-pressure evaporation process. After the solvent is completely evaporated, dry it with air at 45°C to obtain a brown color. Phospholipid complex dry product of milk thistle extract 48.9 grams.

[0034]

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PUM

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Abstract

The invention relates to the field of bio-medicine, in particular to a phospholipid complex of a silybum marianum extract, a preparation method for the phospholipid complex and soft capsules prepared from the complex. According to the phospholipid complex, the preparation method and the soft capsules, the phospholipid complex is prepared from silybum marianum, so that the water solubility of the silybum marianum is greatly improved, the lipid solubility and water solubility of the obtained complex are balanced, and the bioavailability is greatly improved; moreover, the soft capsules prepared from the complex also have high bioavailability, and are convenient to take.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a phospholipid complex of milk thistle extract and a preparation method thereof, as well as a soft capsule prepared from the phospholipid complex and a preparation method thereof. [0002] Background technique [0003] Milk thistle is the dry ripe fruit of Silybum marianum (L.) Gaertn., a plant of Compositae. [0004] Milk thistle extract is a multi-component extract extracted from the seeds of milk thistle with flavonoids as the main component. It is a brown powder, and its signature components include silybin, isosilibin, Substances such as silymarin and silymarin. Milk thistle is an excellent liver-protecting plant, which was recorded in Greek and Roman classics as early as the 1st century AD. The main active ingredient in milk thistle to protect the liver is silymarin. Silymarin can protect and stabilize the liver cell membrane, resist liver cell necrosis, r...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K36/28A61K9/48A61P1/16
Inventor 周勇周晓娟梁呈元吴素琴伍晓月
Owner 江苏健佳药业有限公司
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