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A calcium preparation, a preparing method thereof and applications thereof

A technology of calcium preparations and calcium salts, which is applied in the field of calcium supplementation, and can solve problems such as renal calcification, kidney stones, hypercalcemia, and increased hazards of kidney stones

Active Publication Date: 2014-05-14
SHANGHAI NUOCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] If calcium is supplemented alone, the absorption and utilization rate of calcium is extremely low, and the danger of kidney stones will increase. Usually, vitamin D is added to calcium preparations. However, long-term use of vitamin D and calcium combination will cause hypercalcemia and hypercalciuria. Can cause kidney calcification and kidney stone formation

Method used

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  • A calcium preparation, a preparing method thereof and applications thereof

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preparation example Construction

[0033] The preparation method of calcium preparation provided by the invention comprises steps:

[0034] In the first step, calcium salt is mixed with diluent to obtain mixture 1;

[0035] In the second step, the mixture 1 is subjected to wet granulation with a binder solution containing vitamin K to obtain primary granules;

[0036] In the third step, the vitamin D ethanol solution is sprayed on the primary particles to obtain secondary particles; and

[0037] In the fourth step, the secondary granules are mixed with flavoring agents, lubricants, and / or fillers to obtain the calcium preparation provided by the present invention.

[0038] The diluent described in the first step is selected from two or more of the following: glucose, starch, mannitol, sucrose, xylitol, lactose, dextrin, and microcrystalline cellulose.

[0039] The binder described in the second step is selected from one or more of the following: starch, glucose, povidone, and hydroxypropylmethylcellulose. In...

Embodiment 1

[0063] Preparation of vitamin DK calcium preparation 1 (quantity of 1000 tablets)

[0064] prescription:

[0065] raw material

Usage amount

calcium carbonate

1250

Vitamin D 3

6.5mg

Vitamin K 3

75mg

povidone

38g

glucose

50g

Magnesium stearate

11.5g

[0066] Process steps:

[0067] Pass the prescribed amount of calcium carbonate, vitamin D, and vitamin K through a 100-mesh sieve, and pass the prescribed amount of povidone, glucose, and magnesium stearate through a 80-mesh sieve; dissolve the povidone in water at about 50°C, and stir for 30 Minutes to form a uniform binder solution for later use; put calcium carbonate, glucose, vitamin D, and vitamin K in a V-type mixer and mix evenly; put the mixed materials in a wet granulation pot to make Granules, 20-mesh sieve for granulation; put the granules into a fluidized bed, and dry at 50°C; mix the prepared granules with the prescrib...

Embodiment 2

[0069] Preparation of vitamin DK calcium preparation 2 (quantity of 1000 tablets)

[0070] prescription:

[0071] raw material

Usage amount

calcium carbonate

1250g

Vitamin D 3

10mg

Vitamin K 3

120mg

povidone

35g

glucose

50g

Magnesium stearate

11.5g

[0072] Process steps:

[0073] Pass the prescribed amount of calcium carbonate, vitamin D, and vitamin K through a 100-mesh sieve, and pass the prescribed amount of povidone, glucose, and magnesium stearate through a 80-mesh sieve; dissolve the povidone in water at about 50°C, and stir for 30 Minutes, to form a uniform adhesive solution, set aside; sieve and mix vitamin D, vitamin K and the same amount of glucose, and increase the amount in turn until all the glucose is mixed in, then put the mixture in a V-shaped mixer, add Equal amount of calcium carbonate, increasing in equal amounts in turn until all the calcium carbonate is m...

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Abstract

The invention discloses a calcium preparation, a preparing method thereof and applications thereof. The calcium preparation comprises a calcium salt, vitamin D, vitamin K, mannitol and glucose. The weight ratio of the vitamin D to the calcium salt is 2*10<-6>-22*10<-6>:1. The weight ratio of the vitamin D to the vitamin K is 1:2-50. The weight ratio of the mannitol to the glucose is 1:5-5:1.

Description

technical field [0001] The invention relates to the field of calcium supplementation, in particular to a new calcium preparation and its preparation method and application. Background technique [0002] As people age, osteoporosis has become an important public health problem. According to expert predictions, there are about 84 million osteoporosis patients in my country, accounting for 6.6% of the total population, and the number will double by 2050, which is reasonable. Calcium supplementation can effectively solve this problem, reduce bone loss and reduce the risk of fractures. [0003] If calcium is supplemented alone, the absorption and utilization rate of calcium is extremely low, and the danger of kidney stones will increase. Usually, vitamin D is added to calcium preparations. However, long-term use of vitamin D and calcium combination will cause hypercalcemia and hypercalciuria. Can cause kidney calcification and kidney stone formation. Many stone patients absorb c...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K33/42A61K31/592A61K31/593A61K9/20A23L1/303A23L1/304A61P3/02A61K31/122A61K31/19A61K31/191A61K31/194A23L33/16
Inventor 胡志彤高发红
Owner SHANGHAI NUOCHENG PHARMA
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