A calcium preparation, a preparing method thereof and applications thereof
A technology of calcium preparations and calcium salts, which is applied in the field of calcium supplementation, and can solve problems such as renal calcification, kidney stones, hypercalcemia, and increased hazards of kidney stones
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[0033] The preparation method of calcium preparation provided by the invention comprises the steps:
[0034] In the first step, the calcium salt is mixed with the diluent to obtain mixture 1;
[0035] In the second step, the mixture 1 is wet granulated with a binder solution containing vitamin K to obtain primary granules;
[0036] The third step, spraying the vitamin D ethanol solution on the primary particles to obtain secondary particles; and
[0037] In the fourth step, the secondary particles are mixed with flavoring agents, lubricants, and / or fillers to obtain the calcium preparation provided by the present invention.
[0038] The diluent described in the first step above is selected from two or more of the following: glucose, starch, mannitol, sucrose, xylitol, lactose, dextrin, and microcrystalline cellulose.
[0039] The binder described in the above-mentioned second step is selected from one or more of the following: starch, glucose, povidone, and hydroxypropyl met...
Example Embodiment
[0062] Example 1
[0063] Preparation of Vitamin DK Calcium Formulation 1 (1000 Tablets Quantity)
[0064] prescription:
[0065] raw material
[0066] Process steps:
[0067] Pass the calcium carbonate, vitamin D, and vitamin K in the recipe amounts through a 100-mesh sieve, and pass the recipe amounts of povidone, glucose, and magnesium stearate through an 80-mesh sieve; dissolve the povidone in water at about 50°C, and stir for 30 minutes. 2 minutes, to form a uniform binder solution for later use; put calcium carbonate, glucose, vitamin D, and vitamin K in a V-type mixer, and mix evenly; put the mixed materials in a wet granulation pot to prepare 20 mesh sieve to granulate; put the granulated granules into a fluidized bed, and dry at 50°C; mix the prepared granules with the prescribed amount of magnesium stearate evenly, and press into tablets.
Example Embodiment
[0068] Example 2
[0069] Preparation of Vitamin DK Calcium Formulation 2 (1000 Tablets)
[0070] prescription:
[0071] raw material
[0072] Process steps:
[0073] Pass the calcium carbonate, vitamin D, and vitamin K in the recipe amounts through a 100-mesh sieve, and pass the recipe amounts of povidone, glucose, and magnesium stearate through an 80-mesh sieve; dissolve the povidone in water at about 50°C, and stir for 30 minutes. 10 minutes, to form a uniform binder solution for later use; sieve and mix vitamin D, vitamin K and an equal amount of glucose, and increase in equal amounts in turn, until all the glucose is mixed in, then place the mixture in a V-type mixer, add The same amount of calcium carbonate is increased in equal amounts in turn, until all calcium carbonate is mixed together; the mixed material is placed in a wet granulation pot, granulated, and sized by a 20-mesh sieve; In a chemical bed, dry at 50°C; mix the prepared granules with the presc...
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