An electric field multi-pulse drug release device and its preparation method and application
A multi-pulse and drug-releasing technology, applied in the direction of drug devices and other medical devices, can solve the problems of complex manufacturing methods, and achieve the effects of low cost, great independence, and precise control of drug release time.
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Embodiment 1
[0055] Example 1 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is calcium hydrogen phosphate crystal)
[0056] 1) Weigh a certain amount of gelatin and put it in a container, add double distilled water to fully dissolve, and make a gel solution with a concentration of 1wt% according to the mass volume ratio;
[0057] 2) Mix the above glue solution with calcium nitrate solution with a concentration of 0.01mol / L, the volume ratio is 1:0.5, stir evenly, add a certain volume of glutaraldehyde solution with a mass fraction of 2%, to make the crosslinking degree of gelatin 2% to obtain a mixed cross-linking gel solution;
[0058] 3) Add vitamin C to the above-mentioned mixed cross-linking glue solution. The amount of vitamin C added is 0.5% in terms of weight-to-volume ratio. In the tubular mold, leave a certain space at the mouth of the nozzle, let it stand to make it completely solidified, insert the electrode into the fully solidi...
Embodiment 2
[0061] Example 2 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is barium sulfate crystal)
[0062] 1) Weigh a certain amount of sodium silicate and put it in a container, add double distilled water to fully dissolve, and make a glue solution with a concentration of 80wt% according to the mass volume ratio;
[0063] 2) Mix the above glue solution with barium nitrate solution with a concentration of 5mol / L, the volume ratio is 1:2, after mixing evenly, stir for 1 hour to obtain a mixed crosslinking glue solution;
[0064] 3) Add vitamin C to the above mixed cross-linking gel solution. The amount of rifampicin added is 5% in terms of weight to volume ratio. Mix evenly. Draw a certain amount with the syringe. After standing for 1-2 hours, slowly push it into the opening In the spherical mold tube, leave a certain space at the opening, let it stand to make it completely solidified, insert the electrode into the fully solidified gel, ...
Embodiment 3
[0067] Example 3 Preparation of bionic self-assembled multi-pulse drug release device (precipitation ring layer is calcium hydrogen phosphate crystal)
[0068] 1) Weigh a certain amount of gelatin, put it in a container, add double distilled water to fully dissolve, and make a gel solution with a concentration of 3% according to the mass-volume ratio;
[0069] 2) Mix the above glue solution with calcium chloride solution with a concentration of 0.02mol / L, the volume ratio is 1:1, after mixing evenly, add a certain volume of glutaraldehyde solution with a mass fraction of 1%, and stir for 1 hour to make the gelatin The degree of cross-linking is 1%, and the mixed cross-linking gel solution is obtained;
[0070] 3) Add vitamin C to the above mixed cross-linking glue solution. The amount of vitamin C added is 2% in terms of weight to volume ratio, mix well, draw a certain amount from the syringe, and after standing for 1.5 hours, slowly push it into the open spherical In the mol...
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