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Simulated moving bed chromatographic separation method for omeprazole enantiomer

A technology for simulating moving bed and separating omeprazole, applied in the field of chiral drug separation, can solve the problems of low yield and high cost of chiral enantiomer separation, achieve high yield, improve production environment, and improve automation horizontal effect

Inactive Publication Date: 2014-05-14
JIANGSU HANBON SCI & TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the high cost of omeprazole chiral enantiomer separation, technical defects of low yield, the object of the present invention is to provide a new method for the resolution of omeprazole enantiomers using simulated moving bed chromatography

Method used

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Embodiment Construction

[0012] The specific embodiment of the present invention will be described in detail below. A method for simulating moving bed chromatography to separate omeprazole enantiomers, the method may further comprise the steps:

[0013] 1. Dissolve the omeprazole powder in ethanol solution, and configure it as a 20mg / ml solution as the sample injection solution;

[0014] 2. The packing of the chromatographic column and the composition of the mobile phase:

[0015] The stationary phase is a cellulose triphenylcarbamate coated chiral column, and the coated support is aminopropyl silica gel produced by Fuji Corporation of Japan. The mass ratio of cellulose triphenyl carbamate to aminopropyl silica gel is 1:4. Ethanol mobile phase is ethanol / diethylamine (100 / 0.1, V / V);

[0016] 3. Simulated moving bed chromatography system:

[0017] The simulated moving bed chromatography system includes injection pump, eluent pump, extraction pump, raffinate pump and circulation pump, electromagneti...

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Abstract

The invention relates to separation methods for enantiomer of chiral drugs, especially to a simulated moving bed chromatographic separation method for omeprazole enantiomer. According to the method, an omeprazole synthetic product is used as a raw material, simulated moving bed chromatography is applied for separation of the omeprazole enantiomer, and the stationary phase of simulated moving bed chromatography is a chiral filling material while a mobile phase is an ethanol solution. With the method, yield of the omeprazole enantiomer is high, and purity of the omeprazole enantiomer is more than 98%. Since simulated moving bed chromatography is a continuous process, the automation level and production efficiency can be improved, a production environment is greatly improved, and clean production is realized indeed.

Description

technical field [0001] The invention relates to the field of separation of chiral drugs, in particular to a method for separating omeprazole by using simulated moving bed chromatography. Background technique [0002] Omeprazole (Omepraxole, OME for short) molecule is composed of benzimidazole connected to pyridine ring through sulfoxide group, contains chiral sulfur atom, and has enantiomerism. The two isomers have different biological activities, and the curative effect of S-omeprazole administration is better than that of the racemate form. [0003] Simulated moving bed chromatographic separation technology is a modern separation technology developed in the 1960s. It has strong separation ability, small equipment volume, low investment cost, easy drying and automatic control, and is especially conducive to the separation of heat-sensitive and difficult-to-separate substances. It is most suitable for continuous large-scale industrial production in preparative chromatograph...

Claims

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Application Information

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IPC IPC(8): C07D401/12
CPCC07D401/12
Inventor 张宇张大兵沈健增
Owner JIANGSU HANBON SCI & TECH CO