Method for concentrating cefalexin through membrane method and enzyme concentration method

A technology of cephalexin and concentrated enzyme, which is applied in the direction of organic chemistry, etc., can solve the problems of environmental hazards and high energy consumption of extraction solvent, and achieve the effects of reducing human injury, low energy consumption, and easy modification and replacement of membrane components.

Active Publication Date: 2014-05-14
HARBIN INST OF TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the existing method for concentrating cephalexin needs to use an extraction solvent, which will

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  • Method for concentrating cefalexin through membrane method and enzyme concentration method

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specific Embodiment approach 1

[0017] Specific embodiment one: the method for the present embodiment integrated membrane method and concentrated enzyme method to concentrate cephalexin, carry out according to the following steps:

[0018] 1. Place the cephalexin mother liquor prepared by the concentrated enzyme method in the mother liquor storage tank, and settle for 22h to 26h;

[0019] 2. Adopt a low-pressure pump to transfer the cephalexin mother liquor in the mother liquor storage tank, pass through the fine filter unit, and enter the fine filtrate storage tank;

[0020] 3. The cephalexin liquid in the fine filtrate storage tank is transported by a pump, and the obtained dialysate enters the ultrafiltrate storage tank through the ultrafiltration membrane unit;

[0021] 4. Use a high-pressure pump to transfer the dialysate obtained in step 3 to the first-level nanofiltration membrane unit with an operating pressure of 1.0MPa to 4.0MPa. After passing through the first-level nanofiltration membrane unit, t...

specific Embodiment approach 2

[0025] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the cephalexin mother liquor prepared by the concentrated enzymatic method described in step one is placed in the mother liquor storage tank, and settles for 24 hours. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0026] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the ultrafiltration membrane described in step three is a kind of polymer ultrafiltration membrane or ceramic ultrafiltration membrane, and the form of the ultrafiltration membrane module is Hollow fiber or capillary. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a method for concentrating cefalexin, in particular to the method for concentrating cefalexin through a membrane method and an enzyme concentration method. The method mainly solves the problem that the environment is polluted and energy dissipation is high due to the fact that the existing method for concentrating the cefalexin needs to use the extracting solvent. The method comprises the steps that 1, cefalexin mother solution prepared by the enzyme concentration method is stored into a mother solution storing tank; 2, the cefalexin mother solution passes through a refined filtration unit; 3, the cefalexin mother solution passes through an ultrafiltration membrane unit; 4, the cefalexin mother solution passes through a nanofiltration membrane unit unit; 5, the cefalexin mother solution is conveyed to a reverse osmosis membrane unit, and then the concentrated cefalexin is obtained. By means of the method, the original cefalexin solution can be concentrated more than 10 times, energy dissipation is low, alternative use of the extracting solvent is greatly reduced, harm to human bodies is reduced, and pollution to the environment is avoided. The method is used for concentrating the cefalexin.

Description

technical field [0001] The present invention relates to a method for concentrating cephalexin. Background technique [0002] Cephalexin belongs to cephalosporin antibiotics with a molecular weight of 347.39. Pharmacological cephalexin is a first-generation cephalosporin. Its antibacterial spectrum is similar to that of cephalexin, but its antibacterial activity is worse than that of the latter. In addition to Enterococcus and methicillin-resistant Staphylococcus, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and penicillinase-producing Staphylococcus are sensitive to this product. This product has good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; this product has certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis all showed resistance to this product. Fusoba...

Claims

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Application Information

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IPC IPC(8): C07D501/22C07D501/12
CPCC07D501/12C07D501/22
Inventor 邵路程喜全张聪
Owner HARBIN INST OF TECH
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