Preparation method of lactulose

A lactulose and lactose technology, which is applied in the preparation of sugar derivatives, chemical instruments and methods, disaccharides, etc., can solve the problems of high cost of column chromatography separation equipment, reduced yield of lactulose, and increased degree, and achieves improved ion exchange. Process, the effect of reducing the degree of side reactions and reducing the loss of sugar

Inactive Publication Date: 2014-06-18
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main industrial desalination technologies include ion exchange desalination and membrane separation desalination. The amount of ion exchange desalination resin is large, the adsorption of sugar is serious, and a large amount of acid-base regeneration is required; after the membrane separation technology removes most of the salt in the lactulose syrup, further The removal of residual salt requires the consumption of a large amount of deionized water
Removal of monosaccharides is another difficulty in the purification of lactulose syrup. At present, the main industrial monosaccharide separation technologies include industrial column chromatography and membrane separat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0018] Example one

[0019] A preparation method of lactulose includes the following steps:

[0020] (1) Preparation of lactulose syrup: using 20 kg of food grade lactose as raw material, boric acid as a catalyst, dissolving lactose in 100 L of water, adding 4 kg of boric acid, and then adding solid sodium hydroxide to adjust the pH of the syrup to 12. Stir and react for 1.5 h at 70°C;

[0021] (2) Activated carbon decolorization: use concentrated hydrochloric acid to directly adjust the pH of the reaction solution to 2, add 600 g of activated carbon, keep warm and stir for 1.0 h, and then separate the activated carbon by frame filtration;

[0022] (3) Nanofiltration purification and concentration: use nanofiltration to purify lactulose syrup, the membrane used is Dow NF-270 nanofiltration membrane, the operating pressure is 40 bar, the temperature is 40°C, and water is dialyzed until the conductivity of the syrup is the initial conductivity 3% of

[0023] (4) Removal of residual salt...

Example Embodiment

[0024] Example two

[0025] A preparation method of lactulose includes the following steps:

[0026] (1) Preparation of lactulose syrup: using 24 kg of food grade lactose as raw material, boric acid as a catalyst, dissolving lactose in 120 L of water, adding 4.4 kg of boric acid, and then adding solid sodium hydroxide to adjust the pH of the syrup to 11. Stir and keep warm for 70 min at 80℃;

[0027] (2) Activated carbon decolorization: Use concentrated hydrochloric acid to directly adjust the pH of the reaction solution to 3, add 1200 g of activated carbon, keep it warm and stir for 40 minutes, and then separate the activated carbon by frame filtration;

[0028] (3) Nanofiltration purification and concentration: the lactulose syrup is purified by nanofiltration, the membrane used is Sepro M-8 nanofiltration membrane, the operating pressure is 30 bar, the temperature is 30°C, and water is dialyzed until the conductivity of the syrup is lower than the initial conductivity. 3%;

[0029]...

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Abstract

The invention discloses a preparation method of lactulose. The preparation method comprises the following steps: preparing lactulose syrup, decoloring by use of activated carbon, performing nanofiltration purifying and concentrating, and performing ion exchange to remove residual salt, wherein a nanofiltration membrane for membrane separation is a polyamide membrane with molecular cut off more than 250Da, and the method for removing the residual salt comprises the following steps: adding boron-removal resin in syrup when pH is in range of 7-10, then adding cation exchange resin, and finally regulating the pH value of the syrup as neutral by use of anion exchange resin. The method has the advantages that the content of the lactulose relative to the total sugar can achieve 75-80% by virtue of catalytic isomerization, the color value removal rate of the activated carbon decoloring can achieve 80%; the salt removal rate of the nanofiltration purifying can achieve 97% and more, and the monosaccharide removal rate can achieve 100%; finally the purity of the lactulose relatieve to the total sugar is greater than 90%, and the yield of the lactulose is more than 70%.

Description

technical field [0001] The invention belongs to the field of functional sugars, in particular to a method for preparing lactulose combined with nanofiltration technology. Background technique [0002] Lactulose (also known as isomerized lactose, lactulose) is a disaccharide composed of a molecule of galactose and a molecule of fructose connected by β-1,4 glycosidic bonds. It has the functions of regulating intestinal health, improving human immunity, and promoting nutrition. Absorption and other beneficial effects are important raw materials for medicine, food and feed industries. However, the monosaccharides (glucose and galactose) and lactose present in low-purity lactulose (50-70% to total sugar) will affect its efficacy. In addition, the pigment and residual salt produced by side reactions will cause drug and food safety issues, so it is necessary to establish a method for preparing high-purity lactulose that is easy to industrialize. [0003] At present, the method of...

Claims

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Application Information

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IPC IPC(8): C07H3/04C07H1/00C07H1/06
Inventor 杨瑞金张中华霄赵伟张文斌
Owner JIANGNAN UNIV
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