Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof

A plant polysaccharide and capsule technology, which can be used in capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of unqualified quality, difficult control of capsule preparation process, and moisture absorption and deterioration of drugs.

CN103877587AActive Publication Date: 2014-06-25JIANGSU MARINE RESOURCES DEV RES INST LIAN YUNGANG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2014-06-25

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Abstract

The invention discloses a plant polysaccharide medicinal enteric hard-shell capsule. The capsule mainly consists of the following components in percentage by weight: 10-14% of sodium alginate, 1-3% of carboxy methylated cellulose and 1-1.5% of polyethylene glycol PEG-400 in terms of the sodium alginate. Furthermore, the invention discloses a preparation method of the plant polysaccharide medicinal enteric hard-shell capsule. The hollow capsule disclosed by the invention is prepared from plant polysaccharide edible sodium alginate, and the enteric capsule is more stable in performance compared to a gelatin capsule, good in toughness, thin and elastic in film, difficultly becomes broken and difficultly becomes mildewed; the capsule is not dissolved in the stomach within 2 hours and is completely dissolved in the small intestine after half an hour, so as to avoid irritation of some medicines to the stomach or to avoid influence on a medicine efficacy; specifically, the enteric capsule is more suitable for medicines for treating intestinal diseases and for resisting tumors. The enteric capsule disclosed by the invention is simple and reasonable in composition, good in safety performance and easy to manufacture.
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Description

technical field

[0001] The invention relates to a medicinal enteric-coated hard-shell capsule product; the invention also relates to a method for preparing medicinal enteric-coated hard-shell capsules by using plant polysaccharides. Background technique

[0002] Hollow capsules are one of the most commonly used drug filling materials. They have a bright appearance, can mask the peculiar smell of drugs, are easy to swallow, and are easy for consumers to accept. The bioavailability of functional factors is high, and the amount of excipients is small. It disintegrates quickly, and can disintegrate and release functional substances after taking it. Most of the existing hollow hard capsules are made of animal gelatin as the wall material. Therefore, the current medicinal hard-shell hollow capsules in my country are basically made of animal gelatin as the film-forming capsule material. . However, with the deepening of research, since gelatin is a protein substance, it has strong hy...

Examples

Embodiment 1

[0077] Embodiment 1, a plant polysaccharide medicinal enteric-coated hard-shell capsule, the main weight ratio of the capsule consists of:

[0078] Sodium alginate 10;

[0079] CMC 1;

[0080] Polyethylene glycol PEG-400, its content is 1% of sodium alginate.

Embodiment 2

[0081] Embodiment 2, a plant polysaccharide medicinal enteric-coated hard-shell capsule, the main weight ratio of the capsule is composed of:

[0082] Sodium alginate 14;

[0083] CMC 3;

[0084] Polyethylene glycol PEG-400, its content is 1.5% of sodium alginate.

Embodiment 3

[0085] Embodiment 3, a plant polysaccharide medicinal enteric-coated hard-shell capsule, the main weight ratio of the capsule is composed of:

[0086] Sodium alginate 12;

[0087] CMC 2;

[0088] Polyethylene glycol PEG-400, its content is 1.27% of sodium alginate.