Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof

Abstract

The invention discloses a plant polysaccharide medicinal enteric hard-shell capsule. The capsule mainly consists of the following components in percentage by weight: 10-14% of sodium alginate, 1-3% of carboxy methylated cellulose and 1-1.5% of polyethylene glycol PEG-400 in terms of the sodium alginate. Furthermore, the invention discloses a preparation method of the plant polysaccharide medicinal enteric hard-shell capsule. The hollow capsule disclosed by the invention is prepared from plant polysaccharide edible sodium alginate, and the enteric capsule is more stable in performance compared to a gelatin capsule, good in toughness, thin and elastic in film, difficultly becomes broken and difficultly becomes mildewed; the capsule is not dissolved in the stomach within 2 hours and is completely dissolved in the small intestine after half an hour, so as to avoid irritation of some medicines to the stomach or to avoid influence on a medicine efficacy; specifically, the enteric capsule is more suitable for medicines for treating intestinal diseases and for resisting tumors. The enteric capsule disclosed by the invention is simple and reasonable in composition, good in safety performance and easy to manufacture.

Description

technical field [0001] The invention relates to a medicinal enteric-coated hard-shell capsule product; the invention also relates to a method for preparing medicinal enteric-coated hard-shell capsules by using plant polysaccharides. Background technique [0002] Hollow capsules are one of the most commonly used drug filling materials. They have a bright appearance, can mask the peculiar smell of drugs, are easy to swallow, and are easy for consumers to accept. The bioavailability of functional factors is high, and the amount of excipients is small. It disintegrates quickly, and can disintegrate and release functional substances after taking it. Most of the existing hollow hard capsules are made of animal gelatin as the wall material. Therefore, the current medicinal hard-shell hollow capsules in my country are basically made of animal gelatin as the film-forming capsule material. . However, with the deepening of research, since gelatin is a protein substance, it has strong hy...

AI Technical Summary

Problems solved by technology

However, with the deepening of research, since gelatin is a protein substance, it has strong hygroscopicity and can transfer the absorbed moisture to the drug in it, causing the drug to absorb moisture and deteriorate, resulting in unqualified quality and short validity period. Such substances are prone to cross-linking and curing reactions, which limit the application range of animal gelatin hard capsules. For example, it is not suitable to fill fillers that are easy to absorb moisture, weather and react with the capsule material (such as substances containing aldehyde groups). In addition, gelatin capsules The disintegration performance in the body is easy to fluctuate, which often makes it difficult for the active ingredients of the drug to be released accurately Animal membranes are prone to amino acid cross-linking reactions, resulting in a decrease in the dissolution rate of the membrane, and the animal gelatin membrane has a high proportion of drying weight loss, which is not suitable for filling hygroscopic drugs, and it is also easy to increase the friability of the membrane; moreover, Some unscrupulous companies use industrial gelatin to produce poisonous capsules containing excessive chromium, which brings harm to the health of patients

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