A compound preparation containing capecitabine for gastric cancer treatment

A technology for gastric cancer and pharmaceutical preparations, applied in the field of compound preparations containing capecitabine for the treatment of gastric cancer, which can solve problems such as irritation, gastrointestinal bleeding and bone marrow suppression, and achieve the effects of reducing treatment dosage, reducing production costs and increasing yield

Inactive Publication Date: 2016-06-22
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although capecitabine is effective, it has adverse reactions similar to 5-FU, which can cause nausea, vomiting, diarrhea, gastrointestinal irritation, gastrointestinal bleeding and bone marrow suppression, etc.

Method used

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  • A compound preparation containing capecitabine for gastric cancer treatment
  • A compound preparation containing capecitabine for gastric cancer treatment
  • A compound preparation containing capecitabine for gastric cancer treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0031] The molar ratio of the three compounds in the pharmaceutical composition, and the weight ratio (in single tablet) of related auxiliary materials are shown in the table below:

[0032]

[0033]

[0034] Preparation Process:

[0035] (1) Weighing the pharmaceutical composition, lactose, microcrystalline cellulose and croscarmellose sodium and mixing;

[0036] (2) Put the mixed material in a wet granulator and stir for 3 to 5 minutes. After the stirring is completed, add 10% ethanol aqueous solution to the material to make wet granules. Granulator wet granulation;

[0037] (3) Drying: Put the wet granules into the drying equipment, the air inlet temperature is not higher than 80°C, and the moisture content is controlled to be less than 2%;

[0038] (4) Grain sizing: dry sizing with a sizing machine;

[0039] (5) Total blending: add magnesium stearate to the granulated granules, mix; compress into tablets to obtain.

Embodiment 4

[0040] The experimental research of embodiment 4 pharmaceutical composition of the present invention

[0041] Human gastric cancer cell BGC-823 was cultured in RPMI1640 culture solution (penicillin 100 U / ml, streptomycin 100 mg / L) with volume fraction of 10% inactivated fetal bovine serum, at 37°C, 5% CO 2 , cultured under saturated humidity conditions. Collect the cells in the logarithmic growth phase, stain with 0.4% trypan blue, detect that the cell viability is higher than 95%, and adjust the concentration to 1.0×10 7 ml of cell suspension. Under sterile conditions, the cell suspension was inoculated subcutaneously in the right armpit of nude mice at 0.2 ml / only, and kept for 2 weeks to establish a tumor-bearing nude mouse model.

[0042] The animals were fed with drinking water and oral medicines respectively. 15 animals in each group were administered once a day for 7 consecutive days. After the last administration, the animals were killed by dislocation of the cervic...

Embodiment 5

[0046] The experimental research of embodiment 5 pharmaceutical composition of the present invention

[0047]Human gastric cancer cell line SGC-7901 was cultured in RPMI1640 medium with volume fraction of 10% inactivated fetal bovine serum (penicillin 100U / ml, streptomycin 100mg / L), at 37°C, 5% CO 2 , cultured under saturated humidity conditions. Collect the cells in the logarithmic growth phase, stain with 0.4% trypan blue, detect that the cell viability is higher than 95%, and adjust the concentration to 1.0×10 7 ml of cell suspension. Under sterile conditions, the cell suspension was inoculated subcutaneously in the right armpit of nude mice at 0.2 ml / only, and kept for 2 weeks to establish a tumor-bearing nude mouse model.

[0048] The animals were fed with drinking water and oral medicines respectively. 15 animals in each group were administered once a day for 7 consecutive days. After the last administration, the animals were killed by dislocation of the cervical spin...

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PUM

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Abstract

The invention relates to an antitumor drug preparation for treating a gastric cancer. The compound preparation is prepared from a pharmaceutical composition and pharmaceutically acceptable auxiliary materials, wherein the pharmaceutical composition is prepared from capecitabine, oleuropein and glycyrrhizin; the auxiliary materials preferably are lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate and the like. Furthermore, the drug preparation is prepared from the following components in parts by weight: 300-500 parts of pharmaceutical composition, 20-30 parts of lactose, 80-100 parts of microcrystalline cellulose, 20-30 parts of croscarmellose sodium and 3 parts of magnesium stearate.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a compound preparation containing capecitabine for treating gastric cancer. Background technique [0002] Gastric cancer is a common malignant disease, one of the main causes of death worldwide, and brings great difficulties to clinical treatment. Due to the hidden onset of gastric cancer, most of the clinically diagnosed gastric cancer patients in China currently have It is an advanced stage, and less than 50% of gastric cancer patients are detected early. The medical effect of advanced gastric cancer is not ideal. According to domestic data, the 5-year survival rate of advanced gastric cancer is only about 15%, and foreign data are only . At present, the methods commonly used in the treatment of gastric cancer are as follows: [0003] Radical surgery: At present, the effective treatment of gastric cancer is still based on radical surgery. After radical r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7068A61K9/20A61P35/00A61P1/00A61K31/352A61K31/7048
Inventor 孔庆暖韩增磊卫红军黄维清
Owner QINGDAO MUNICIPAL HOSPITAL
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