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Preparation method and detection method of Gongyanping dispersible tablet

A technique for Gongyanping dispersible tablets and a detection method, which is applied in the field of preparation of Gongyanping dispersible tablets, and can solve the problems of undisclosed components of Gongyanping dispersible tablets, undisclosed Gongyanping dispersible tablets, and undisclosed preparation of Gongyanping dispersible tablets. Evenly dispersible tablet detection method and other problems, to achieve the effect of shortening the disintegration time limit, reducing the quality of control, and stable and uniform quality

Active Publication Date: 2016-06-08
JIANGXI MINJI MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, patent applications related to Gongyanping dispersible tablets are relatively rare in the prior art. For example, only 2004100450226 patent application does not specifically disclose the specific ingredients of Gongyanping dispersible tablets, nor does it specifically disclose how to prepare Gongyanping dispersible tablets. , not to mention the detection method for the preparation of Gongyanping dispersible tablets

Method used

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  • Preparation method and detection method of Gongyanping dispersible tablet
  • Preparation method and detection method of Gongyanping dispersible tablet
  • Preparation method and detection method of Gongyanping dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0048] Diren 450g Liangmianzhen 170g Angelica 140g

[0049] Five Fingers Peach 100g Piercing Stone 140g Microcrystalline Cellulose 110g

[0050] Cross-linked polyvinyl pyrrolidone 35g starch 35g magnesium stearate 0.86g

[0051] Concrete preparation method comprises the following steps:

[0052] (1) Decoction: Take 450g of the above medicinal materials Diren, 170g of Liangmianzhen, 140g of Angelica, 100g of Wuzhi Maotao, 140g of Chuanposhi, add 6 times the amount of water and decoct twice, each time for 2 hours, filter, and combine the decoction , the filtrate is set aside,

[0053] (2) Concentration and alcohol precipitation: Take the above-mentioned filtrate and concentrate it under reduced pressure (-0.04Mpa~0.06Mpa) to form an extract with a relative density of 1.25 (55~60°C); Then add ethanol, and make the alcohol content reach 50%, let it stand for 24 hours,

[0054] (3) Recovery of ethanol and concentration: the above-mentioned alcohol-precipitated drug solution is ...

experiment example 1

[0072] Experimental example 1: Investigation of the amount of water added in the decoction process

[0073] This project adopts the orthogonal design to optimize the process conditions, and investigates the three factors of water addition, decoction time and decoction times respectively, and uses the orthogonal table L 9 (3 4 ) for the test, the schemes are shown in Tables 1 and 2, and the experimental methods and results are shown in Tables 3 and 4.

[0074] Table 1

[0075]

[0076] Table 2 Level arrangement of water decoction process factors

[0077]

[0078] Detection index: Since the medicinal material of Diren is a monarch drug, and Diren contains gallic acid, the detection index takes the extraction rate of gallic acid as the inspection index. According to the quality standards of Diren medicinal materials, the gallic acid contained in Diren shall not be less than 0.05%. The measured gallic acid content was 0.07%.

[0079] Preparation and determination of the ...

experiment example 2

[0093] Experimental Example 2: Optimization of drying method and investigation of paste yield

[0094] The drying method of the thick paste in the present invention usually adopts normal temperature and pressure drying or vacuum drying, for this reason we get 2 prescriptions (2000g) medicinal materials altogether 4 parts, add 6 times of amount water respectively and decoct twice, each time 2 hours, filter After that, combine the filtrates, concentrate to a relative density of 1.25 (55-60°C), add ethanol until the alcohol content reaches 50%, let it stand for 24 hours, filter, recycle the ethanol from the filtrate, concentrate to different relative densities respectively, and use Normal temperature and pressure drying (atmospheric pressure, 60-80°C) or vacuum drying (-0.06-0.08Mpa, 60-80°C), the results are shown in Table 5.

[0095] Table 5 The time spent in different drying methods and the paste yield of samples

[0096]

[0097]

[0098] The results in Table 5 show th...

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Abstract

The invention relates to a preparation method and a detection method of hysteritis-treating dispersible tablets. The preparation method differs from ordinary tablets in that a preferred prescription is adopted, a disintegrating agent is applied internally and externally, and Chinese medicinal tablets are prepared into Chinese medicinal dispersible tablets which have stable and uniform quality and can be totally disintegrated within three minutes. A quality detection method provided by the invention relates to thin-layer chromatography identification of melastoma dode candrum lour, zanthoxylum nitidum and ficus simplicissima Lour as well as high performance liquid chromatography content determination and limit of gallic acid.

Description

technical field [0001] The invention relates to a preparation method and detection method of Gongyanping dispersible tablet. Background technique [0002] Pelvic inflammatory disease (Pelvic inflammatory disease, PID) refers to the inflammation of the female upper reproductive tract and its surrounding tissues, mainly including endometritis (endometritis), salpingitis (salpingitis), tubo-ovarian abscess (tubo-ovarian abscess, TOA), pelvic peritonitis (peritonitis) ). Inflammation can be limited to one position, and can also involve several positions at the same time, and the most common ones are salpingitis and salpingo-oophoritis. Pelvic inflammatory disease mostly occurs in women who are sexually active and menstruating. Pelvic inflammatory disease rarely occurs in premenarche, postmenopausal or unmarried women. If pelvic inflammatory disease occurs, it is often the spread of inflammation in adjacent organs. According to its pathogenic process and clinical manifestations...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/88A61K36/758A61K9/20A61K47/32A61P15/00
Inventor 文萍虞金宝吕武清李明辉王刚
Owner JIANGXI MINJI MEDICINE
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