2-(alpha-hydroxy pentyl) benzoate controlled-release tablet and preparation method thereof
A benzoate and hydroxypentyl technology, which is applied in the field of 2-(α-hydroxypentyl)benzoate controlled-release tablets and their preparation, can solve the problems of inability to exert long-term effects and short half-life, and achieve shortening Medication cycle, maintenance of blood drug concentration, and effect of increasing compliance
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[0021] Described preparation method specifically comprises:
[0022] a. Pass 2-(α-hydroxypentyl) benzoate, slow and controlled release framework materials and auxiliary materials through 80-mesh sieve respectively, and then mix in a mixer for at least 30 minutes to achieve uniformity;
[0023] b. The stabilizer and auxiliary materials are also passed through a 80-mesh sieve, and then dissolved with a wetting agent and mixed evenly;
[0024] c. Send the mixed solid material to the wet granulator with a vacuum feeder, then add the prepared wetting agent to the wet granulator through the compressed air through the pressure tank, and mix in the wet granulator At least 15 minutes, pass through a 12-18 mesh sieve through a granulator to make granules. The granules enter the fluidized drying bed for 40 minutes by gravity or vacuum, and the drying temperature is controlled below 65 ° C. The dried granules pass through the lifting transfer machine Enter the granulator, the granulated ...
Embodiment 1
[0043] prescription:
[0044] Potassium Hydroxypentyl Benzoate (PHPB) raw material: 100mg
[0045] Disodium hydrogen phosphate-sodium hydroxide: 10mg
[0046] HPMC: 10mg
[0047] Hydroxypropyl Cellulose - Hydroxypropyl Methyl Cellulose Phthalate: 100mg
[0048] Magnesium stearate: 5mg
[0049] Purified water 1-2ml, ethanol 3-5ml
[0050] Coating material: cellulose acetate 1-2mg
[0051] 1. Pass potassium hydroxypentyl benzoate (PHPB), hydroxypropyl cellulose-hydroxypropyl methyl cellulose phthalate through an 80-mesh sieve and add to a three-dimensional mixer to mix for 30±10 minutes.
[0052] 2. Pass disodium hydrogen phosphate-sodium hydroxide and HPMC through 80-mesh sieve respectively, dissolve in ethanol and set aside.
[0053] 3. Mix the two ethanol solutions in 2 for later use.
[0054] 4. Put the material formed in 1 into a wet granulator, then add the wetting agent in 3 and mix for at least 15 minutes to make a soft material.
[0055] 5. Make the soft material ...
Embodiment 2
[0061] Potassium hydroxypentylbenzoate (PHPB) raw material: 100mg
[0062] Disodium hydrogen phosphate-sodium hydroxide: 10mg
[0063] Microcrystalline Cellulose: 15mg
[0064] CMC: 80mg
[0065] Magnesium stearate: 5mg
[0066] Purified water 1-2ml, ethanol 3-5ml
[0067] Coating material: acrylic resin IV No. 1-2mg
[0068] 1. Pass potassium hydroxypentyl benzoate (PHPB), CMC, and microcrystalline cellulose through an 80-mesh sieve first, then add to a three-dimensional mixer and mix for 30±10 minutes.
[0069] 2. Pass disodium hydrogen phosphate-sodium hydroxide through an 80-mesh sieve and dissolve it in ethanol for later use.
[0070] 3. Reserve the ethanol solution in 2.
[0071] 4. Put the material formed in 1 into a wet granulator, then add the wetting agent in 3 and mix for at least 15 minutes to make a soft material.
[0072] 5. Make the soft material into wet granules through the granulator.
[0073] 6. Dry the wet granules; the drying temperature is 45-70°C...
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