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Preparation method of grain size controllable monodisperse nano starch microspheres

A nano-starch, monodisperse technology, applied in the direction of non-active ingredient medical preparations, powder delivery, pharmaceutical formulations, etc., can solve the problems of unreachable, large size, and inability to control the particle size of microspheres, and achieve uniform size, Good application effect and good targeted effect

Inactive Publication Date: 2014-08-27
XIHUA UNIV
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AI Technical Summary

Problems solved by technology

[0008] The existing starch microspheres mainly focus on the control of cross-linking agent, cross-linking density, and targeting during the preparation of microspheres. Although there are reports of nano-microspheres, they are often large in size (hundreds of nanometers, which cannot reach Some special lesions), and the particle size of the microspheres cannot be adjusted, let alone monodisperse distribution

Method used

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  • Preparation method of grain size controllable monodisperse nano starch microspheres
  • Preparation method of grain size controllable monodisperse nano starch microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Example 1: 150 g of soluble starch was dissolved in 1350 g of distilled water to prepare a starch solution with a concentration of 10%. 600 g of water-soluble surfactant Tween 20 and 6.1 g of inorganic salt NaCl were added to the solution, and the pH was adjusted to 9-10 with NaOH solution to obtain an aqueous phase. In addition, 1600g of oil-soluble surfactant Span80 and 53g of co-surfactant n-propanol were added to 4000g of organic solvent kerosene to obtain an oil phase. The oil phase and the water phase were mixed, mechanically stirred evenly, and left to stand for 2 hours to obtain a water-in-oil microemulsion.

[0040] Add the above-mentioned water-in-oil starch microemulsion into a 10000ml four-neck flask, stir mechanically (rotating speed 400rpm), pass nitrogen protection (gas flow rate is 10ml / min), add 32g cross-linking agent N,N-methylenebis Acrylamide, 5.6g water-soluble initiator ammonium persulfate, heat up to 45°C, keep warm at this temperature for 5h to...

Embodiment 2

[0041] Example 2: 100 g of soluble starch was dissolved in 700 g of distilled water to prepare a starch solution with a concentration of 12.5%. 225g of water-soluble surfactant Tween80 and 2.2g of inorganic salt KCl were added to the solution, and the pH was adjusted to 9-10 with NaOH solution to obtain an aqueous phase. Add 750g oil-soluble surfactant Span60 and 35g co-surfactant n-butanol to 3000g organic solvent kerosene in addition to obtain an oil phase. The oil phase and the water phase were mixed, mechanically stirred evenly, and left to stand for 1.5 hours to obtain a water-in-oil microemulsion.

[0042] Add the above-mentioned water-in-oil starch microemulsion into a 5000ml four-neck flask, stir mechanically (rotating speed 400rpm), pass nitrogen protection (gas flow rate is 10ml / min), add 18g cross-linking agent N,N-methylenebis Acrylamide, 3.5g water-soluble initiator cerium ammonium nitrate, heated up to 55°C, kept at this temperature for 4h to carry out cross-lin...

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Abstract

The invention aims to provide a method of controlling the grain size of starch microspheres so as to further prepare monodisperse nano starch microspheres in different grain sizes. The technical scheme provided by the invention is as follows: the preparation method comprises the following steps: preparing a starch solution; adding a water soluble surfactant and inorganic salt into the starch solution to obtain a water phase matter; adding an oil soluble surfactant and a co-surfactant into an organic solvent to obtain an oil phase matter; and mixing the water phase matter with the oil phase matter to obtain a water in oil starch microemulsion, cross-linking and solidifying, collecting precipitates, and washing and drying the precipitates to obtain white-to-yellowish powder which is the monodisperse nano starch microspheres. According to the preparation method provided by the invention, the grain size of the starch microspheres can be precisely controlled within a certain range (20-200nm) through selection of reaction raw materials and control of technical conditions, and the grain size is distributed in a monodisperse mode. The starch microspheres can be used as a carrier of a medicine, has better targeting and is oriented to a special organ or focus part.

Description

technical field [0001] The invention belongs to the fields of natural polymer material modification and medicinal polymer material. The invention relates to a method for preparing nano-scale starch microspheres by inverse suspension microemulsion polymerization using starch as the main raw material. The shape of starch microspheres is approximately spherical, the particle size distribution is concentrated, and approximately monodisperse; the surface of the microspheres is rough and has a certain adsorption to fluids, and can be used as immobilization materials for fluids, especially as carriers of drugs. Background technique [0002] Starch microspheres are a kind of cross-linking material with spherical or nearly spherical appearance and particle size ranging from nanometers to millimeters, which is prepared by grafting and crosslinking modification reactions between crosslinking agents and hydroxyl groups in starch molecules under certain conditions. Linked starch, its re...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F2/32A61K9/14A61K47/36
Inventor 马素德闵忠华张勤勇袁乐
Owner XIHUA UNIV
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