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Precious metal/paramagnetic metal composite nanoparticle with core-shell structure and application thereof

A technology of composite nanoparticles and paramagnetic metals, applied in the fields of magnetism of organic materials/organic magnetic materials, preparations for in vivo tests, microcapsule preparations, etc., to achieve high relaxation rate and regular structure

Inactive Publication Date: 2014-09-10
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, no research based on this aspect has been reported

Method used

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  • Precious metal/paramagnetic metal composite nanoparticle with core-shell structure and application thereof
  • Precious metal/paramagnetic metal composite nanoparticle with core-shell structure and application thereof
  • Precious metal/paramagnetic metal composite nanoparticle with core-shell structure and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Step a: Add 3 mL of 0.03 mol L to 100 mL of deionized water under stirring at 25 °C -1 Sodium citrate solution, heated while stirring until boiling. After the solution boils, quickly add 1mL to a concentration of 0.02mol L -1The gold chloride solution is heated and slightly boiled and stirred for 5 minutes, then the stirring and heating are stopped, and cooled to room temperature to obtain a gold nanoparticle aqueous sol with a particle size distribution of 5-50nm;

[0034] Step b: Take 2 mL of the gold nanoparticle aqueous sol prepared in step a and redisperse it with 10 mL of methanol, add 5 g of 2-mercapto-5-aminobenzimidazole, and under the protection of nitrogen, stir and react at 0°C in the dark for 24 hours, the reaction mixture Dialyze in methanol through a dialysis membrane with a molecular weight cut-off of 3500Da, remove most of the methanol solvent by rotary evaporation, and then react with 20 mL of methyl acrylate at room temperature for 48 hours. The reac...

Embodiment 2

[0039] Embodiment 2 (with embodiment 1, replace gold nanoparticle with silver nanoparticle and get final product)

[0040] Step a: Dissolve 25 mL of 2×10 in an ice-salt bath under vigorous stirring -3 M silver nitrate solution was added dropwise to 25mL8×10 -3 M sodium borohydride aqueous solution, the dropwise addition time is controlled within 30 minutes. With the addition of silver nitrate, the color of the reducing agent aqueous solution gradually changed from colorless to light yellow, and finally to brownish yellow, that is, the silver nanoparticle hydrosol was obtained, and the particle size distribution was 5-50nm.

[0041] Step b: Take 2mL of the silver nanoparticle hydrosol obtained in step a, redisperse it with 50mL of methanol, add 5g of 2-mercapto-5-aminobenzimidazole, and react at a constant temperature of 20°C for 48 hours under the protection of nitrogen. , the reaction mixture was dialyzed in methanol through a dialysis membrane with a molecular weight cut-o...

Embodiment 3

[0046] Step a, under stirring at 25°C, add 3 mL of 0.03 mol L to 100 mL of deionized water -1 Sodium citrate solution, heated while stirring until boiling. After the solution boils, quickly add 1mL to a concentration of 0.02mol L -1 The gold chloride solution was heated to a slight boil and stirred for 5 minutes, then the stirring was stopped and heated and cooled to room temperature to obtain an aqueous sol of gold nanoparticles with a particle size distribution of 5-50 nm.

[0047] In step b, take 2 mL of the gold nanoparticle hydrosol prepared in step a and redisperse it with 10 mL of methanol, add 5 g of 3-mercapto-4-aminobenzoic acid, and under the protection of nitrogen, stir and react at 0°C in the dark for 24 hours, and the reaction mixture is passed through A dialysis membrane with a molecular weight cut-off of 3500Da was dialyzed in methanol, most of the methanol solvent was removed by rotary evaporation, and then reacted with 20mL methyl acrylate at room temperatur...

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Abstract

The invention discloses a precious metal / paramagnetic metal composite nanoparticle with a core-shell structure and application thereof. A preparation method for the precious metal / paramagnetic metal composite nanoparticle comprises the following steps: (a) preparing a precious metal nanoparticle with a particle size of 5 to 50 nm, wherein the precious metal is gold or silver; (b) taking a compound A containing a mercapto group and an amino group, allowing the precious metal nanoparticle to react with the compound A so as to obtain a product a and then allowing the product a to react with methyl acrylate so as to obtain a product b; (c) taking a compound C containing an azido group and an amino group and reacting the product obtained in the step (b) with the compound C so as to obtain an azido-surface-modified precious metal nanoparticle; (d) subjecting the azido-surface-modified precious metal nanoparticle prepared in the step (c) and a micromolecular ligand containing an alkynyl group to the Clicker reaction so as to obtain a product d; and (e) reacting the product d with a chloride of a paramagnetic metal so as to obtain the composite nanoparticle. The precious metal / paramagnetic metal composite nanoparticle can be used as an MRI and CT enhancement contrast agent.

Description

technical field [0001] The invention relates to a noble metal / paramagnetic metal composite nanoparticle with a core-shell structure and its application in the field of nanotechnology, especially the application as an MRI and CT enhanced contrast agent. technical background [0002] The particularity of metal-organic composite nanoparticles determines its unique chemical and physical properties and is widely used in the fields of light, electricity, catalysis, and immunodetection. Recent studies have shown that magnetic nanoparticles can increase the electron density of paramagnetic metal chelates and accelerate the exchange rate of paramagnetic metals with surrounding water molecules. The existence of noble metal nanoparticles is beneficial to accelerate the outer electron rotation of paramagnetic metal ions, which can be used to increase the relaxation rate of paramagnetic metal ions. Moriggi reported that in a composite system containing 201 gold nanoclusters and 56 param...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02H01F1/42A61K49/04A61K49/10
Inventor 张伟禄史晓妮项泓翰吴波
Owner WENZHOU UNIVERSITY
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