Benzothiazole and triazolediheterocycle-containing fused ring compound and application thereof

Abstract

The invention relates to a benzothiazole and triazolediheterocycle-containing fused ring compound which has a structure of a general formula Y shown in the specification. According to the compound, cyclic amine with bioactivity is connected to the site 4 of naphthalimide, a structure that an imine nitrogen atom of naphthalimide is spaced from a triazole nitrogen atom connected with a side chain by two carbon atoms is kept, and molecules are introduced into sulfur-containing heterocyclic benzothiazole through linkage of triazole, so that the diversity of naphthalimide derivatives, the bioactivity of naphthalimide and the DNA identification and intercalation capability are improved; the compound has a relatively good inhibition effect on normal growth of tumor cells, with different tissue sources, of cervical cancers, liver cancers, breast cancers and the like.

Description

technical field

[0001] The invention relates to a class of bis-heterocyclic naphthalimide compounds containing benzothiazole and triazole in the field of bioorganic synthesis, a preparation method and application thereof. Background technique

[0002] Most of the molecules containing the naphthalimide parent structure are fluorescent and the compounds show a wide range of biological activities, such as anticancer drugs, antitrypanosomal agents, antiviral, local anesthetic, analgesic, serotonin 5-HT3 and 5-HT4 antibody antagonists, chemical sensors, etc. Anticancer drugs based on naphthalimide, such as Amonafide, Mitonafide and UNBS5162, have also entered clinical trials at different stages, but Amonafet and Mitonafide are due to their toxic and side effects. further research was inhibited. to 1973, reported for the first time that 3-nitronaphthoimide derivatives have antitumor activity, and then synthesized many naphthalimide compounds with antitumor activity by modifyin...

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