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A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography

A microfluidic chip and ultraviolet light technology, which is applied in the field of analysis and detection, can solve problems such as high complexity, low manufacturing precision, and difficult high-throughput detection, and achieve the effects of improved resolution, stable performance, and improved detection efficiency

Active Publication Date: 2015-08-19
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of these two methods are low manufacturing precision, high complexity, difficulty in high-throughput detection, etc.

Method used

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  • A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography
  • A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography
  • A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A method for preparing a cloth-based microfluidic chip based on ultraviolet lithography technology, comprising the steps of:

[0047] (1) Preparation of polyvinyl alcohol cinnamate (PVC) photoresist

[0048] Dissolve 15% PVC in 84.7% cyclohexanone, stir well, then add 0.3% 5-nitroacenaphthene, stir well to obtain polyvinyl alcohol cinnamate photoresist (PVC photoresist), transfer to brown bottle Among them, place it away from light for use; the percentage mentioned is the percentage of each raw material accounting for the total mass of the photoresist raw material;

[0049] (2) Fabrication of cloth-based microfluidic chips

[0050] (a) Mask production: use Adobe Illustrator CS4 software to design the mask pattern of the microchannel width resolution of the cloth-based microfluidic chip (such as figure 2 As shown in a), the black part is the light-shielding part (corresponding to the hydrophilic region on the cloth-based microfluidic chip), and the white part is the l...

Embodiment 2

[0066] A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography technology, except for the following special instructions, other steps and materials are the same as in Example 1.

[0067] During the preparation process, several dike widths are set on the same cloth-based microfluidic chip to study its resolution. The design is as follows: image 3 For the mask shown in a, the black part corresponds to the hydrophilic region on the bucky microfluidic chip, and the white part corresponds to the hydrophobic region on the bucky microfluidic chip. image 3 The text below a indicates the width of the corresponding row of dams.

[0068] For the hydrophobic region, the width of all outer white square rings is 300 microns, while the width of the inner white square rings (ie, the width of the hydrophobic dam) is 100, 200, 300, 400, 500 and 600 microns from left to right.

[0069] image 3 b is the physical map of the cloth-based microfluidic chip processe...

Embodiment 3

[0071] A method for fabricating a cloth-based microfluidic chip based on ultraviolet lithography technology, except for the following special instructions, other steps and materials are the same as in Example 1.

[0072] During the preparation process, an array of circular reaction cells (such as Figure 4 As shown in a, the reaction pool is the hydrophilic area, and the detection area and the sample injection area are the same reaction pool) for high-throughput glucose detection, and the diameter of each pool is 3 mm.

[0073] The glucose detection process is as follows: firstly, add 0.3 mol / L trehalose and 0.6 mol / L potassium iodide mixed solution into the array reaction cell, and dry at room temperature for 10 minutes; then add glucose oxidase solution and horseradish hydrogen peroxide with a volume ratio of 5:1 Enzyme solution (glucose oxidase activity is 120 units / ml, horseradish catalase activity is 30 units / liter), and dried at room temperature for 10 minutes to complet...

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Abstract

The invention discloses a preparation method for an ultraviolet photoetching technique-based cloth micro fluidic chip. The preparation method for the ultraviolet photoetching technique-based cloth micro fluidic chip comprises the following steps: 1. PVC photoresist is prepared; 2. cloth pieces are pretreated; 3.a mask is designed; 4. the cloth pieces are uniformly coated with the PVC photoresist; after the prebaking, the cloth pieces are placed on a piece carrying platform; the mask is aligned, so as to conduct ultraviolet exposure; after the post baking, then, the gummed cloth pieces are placed into butanone for development; the gummed cloth pieces are placed into acetone for rinse; after the gummed cloth pieces are rinsed by purified water, the SDS solution is adopted to wash the gummed cloth pieces; the gummed cloth pieces are subject to the rinse of purified water again; after drying, the cloth micro fluidic chip is obtained. Compared with the pattern wax molding method and the textile method processing, the preparation method for the ultraviolet photoetching technique-based cloth micro fluidic chip can process hydrophobic regions and hydrophilic regions with high resolution factors on the cloth micro fluidic chip; the width of the hydrophilic channel on the cloth base micro fluidic chip is as low as 500 micron; the width of a drainage dam is as low as 100 micron; the flux is high; the accuracy is high; the processing efficiency and detection efficiency are high.

Description

technical field [0001] The invention belongs to the field of analysis and detection, and in particular relates to a cloth-based microfluidic chip, in particular to a method for preparing a cloth-based microfluidic chip based on ultraviolet lithography technology. Background technique [0002] In the early 1990s, the concept of micro total analysis systems (μ-TAS) was first proposed, and has developed rapidly in the following two decades, becoming one of the most cutting-edge technologies today. The purpose of μ-TAS is to miniaturize and integrate analytical equipment, that is, to integrate the functions of traditional laboratories into a chip of a square inch, to realize the miniaturization and portability of analytical equipment, thereby breaking the long-term dependence of scientific analysis on traditional laboratory analysis. The pattern of analysis enables analysis equipment to enter thousands of households. μ-TAS has the characteristics of less sample volume, fast det...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 章春笋吴培京
Owner SOUTH CHINA NORMAL UNIVERSITY
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