A kind of aminoglycerin refining device and its purification process

Abstract

The invention discloses a refining apparatus of 3-amino-1,2-propanediol. The apparatus comprises a crystallization kettle, a first precision filter, a decolorizing kettle, a second precision filter, a finished product distillation kettle, a condenser, a front cut fraction tank, a finished product tank and a roots vacuum system which are sequentially connected through a pipeline; the crystallization kettle is provided with a cold brine outlet, a cold brine inlet and an unqualified 3-amino-1,2-propanediol outlet, unqualified 3-amino-1,2-propanediol is added into the crystallization kettle and is processed for 60-80min, and the obtained material 1 is pumped into the first precision filter; the obtained material 2 enters the decolorizing kettle; and ethanol is added to the decolorizing kettle, the obtained mixture 3 is stirred, activated carbon and, activated white clay are added into the decolorizing kettle, the obtained mixture 4 is continuously stirred, the finally obtained material in the decolorizing kettle is pumped into the second precision filter, and the newly obtained material enters the finished distillation kettle and is distilled to firstly obtain ethanol to be continuously used. A homologous compound 2-amino-1,3-propanediol and polyglycerine precipitate from the above obtained product by adopting a crystallization kettle freezing process, so the content of 2-amino-1,3-propanediol in the finished product is greatly reduced.

Description

technical field [0001] The present invention relates to a refining process and device for aminoglycerol, in particular to a refining device and its purification process capable of improving the purity of aminoglycerin with low purity, colored appearance and high impurity content to more than 99.7%. chemical technology field. Background technique [0002] Aminoglycerin (3-amino-1,2-propanediol) is a structural unit for the production of non-ionic contrast agent iodide X-ray contrast agent, used in the synthesis of iohexol, ioversol and iodixanol, etc., and also used as an anti-inflammatory Important intermediates of medicines, analgesics, cosmetics, certain synthetic materials, etc. In order to minimize the side effects on patients and reduce adverse reactions, the purity of aminoglycerin should not be lower than 99.5% (GC), and the content of inorganic salts should be controlled. [0003] At present, the starting raw material of aminoglycerol is basically the reaction of c...

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Problems solved by technology

[0007] The purpose of this invention to solve local problems is to overcome the common defects in the aminoglycerin industry that the products are yellow, brown, red, brownish yellow, yellowish brown or light yellow, the number of impurities is large, the content of impurities is high, and the product purity is low. A refining device for post-processing aminoglycerin of unqualified products

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