Amphipathy photoswitch fluorescent polymer nano particles and preparing method thereof

A fluorescent polymer and nanoparticle technology, applied in chemical instruments and methods, luminescent materials, etc., can solve problems such as complex preparation process, poor repeatability, surfactant migration or aggregation instability, and improve photostability , enhance the fluorescence brightness, improve the stability of the effect

Inactive Publication Date: 2014-11-12
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, among these existing preparation methods, the sol-gel method has harsh synthesis conditions and poor reproducibility; the nanoparticle surface modification method and the block copolymer self-assembly method require complex preparation processes, which are not cond

Method used

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  • Amphipathy photoswitch fluorescent polymer nano particles and preparing method thereof
  • Amphipathy photoswitch fluorescent polymer nano particles and preparing method thereof
  • Amphipathy photoswitch fluorescent polymer nano particles and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1: Preparation of amphiphilic photoswitchable fluorescent polymer nanoparticles by one-step RAFT miniemulsion polymerization.

[0030] (1) Mix 0.5g methyl methacrylate, 0.003g 2,6-diethyl-8-(4-(methacryloyloxy)phenyl-1,3,5,7-tetramethyl- Fluorobordimethylene (BDPMA), 0.015g ethyl-3,3-dimethyl-6-nitroindoline spiropyranyl methacrylate (SPMA), 0.025g n-hexadecane, 0.006g azo Diisobutyronitrile was mixed and stirred evenly, dispersed in 10ml of an aqueous solution of polyethylene oxide macromolecular chain transfer agent with a concentration of 0.0075g / mL, ultrasonically emulsified to form a stable and uniform fine emulsion, and reacted at 75°C for 7 hours to obtain this An amphiphilic photoswitchable fluorescent polymer nanoparticle.

Embodiment 2

[0031] Embodiment 2: Test the particle size and distribution of the amphiphilic photoswitchable fluorescent polymer nanoparticle samples prepared in Embodiment 1.

[0032] The specific test instrument is Malvern Nano-ZS90 laser particle size analyzer, the test concentration is 0.3wt% solid content, and the test temperature is 25oC.

[0033] figure 2 It is the particle size and distribution diagram of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in Example 1, and the result shows that the average particle size of the prepared fluorescent polymer nanoparticle sample is 80nm, and the particle size distribution is narrow.

Embodiment 3

[0034] Embodiment 3: Test the ultraviolet-visible absorption spectrum and fluorescence emission spectrum of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in embodiment 1.

[0035] The specific test instruments are: Shimadzu UV-2501PC ultraviolet-visible absorption spectrometer, Shimadzu RF-5301PC fluorescence spectrometer, the test concentration is 0.3wt% solid content, and the test temperature is 25oC.

[0036] (1) UV-Vis absorption spectrum

[0037] image 3 It is the ultraviolet-visible absorption spectrum of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in Example 1 in the range of 300nm to 700nm. from image 3 It can be seen from the figure that under the irradiation of 525nm visible light (power 2W, the same below), the sample has an absorption peak corresponding to BDPMA at 525nm, and almost no absorption peak corresponding to SPMA at 560nm; , the same below), the sample showed absorption peaks corre...

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Abstract

The invention discloses amphipathy photoswitch fluorescent polymer nano particles and a preparing method of the amphipathy photoswitch fluorescent polymer nano particles. Methyl methacrylate, polymerizable green fluorescence dye and a polymerizable photochromic compound are taken as monomers, hexadecane is taken as hydrophobe, a polyoxyethylene macromolecular chain transfer reagent is taken as a surface active agent, a one-step reversible addition-fragmentation chain transfer (RAFT) miniemulsion polymerization method is adopted for preparing the novel amphipathy photoswitch fluorescent polymer nano particles. The amphipathy photoswitch fluorescent polymer nano particles can emit intense macroscopic green or red fluorescence under irradiation of visible light and ultraviolet light, and have fast photoresponse capacity and good repeated fluorescence reversible switch performance. The amphipathy photoswitch fluorescent polymer nano particles have wide application prospects in the fields of cell imaging, bioanalysis, optical storage and the like.

Description

technical field [0001] The invention relates to the field of material preparation, in particular to amphiphilic light-switchable fluorescent polymer nanoparticles with fluorescence reversible switch performance under the irradiation of ultraviolet light and visible light and a preparation method thereof. Background technique [0002] In recent years, optically switchable fluorescent materials have received increasing attention in the fields of ultra-high-resolution cell imaging, labeling of complex biological systems, and ultra-high-density optical data storage applications. For example, optical switching fluorescent materials based on spiropyran derivatives, diarylethene derivatives, etc. have good optical rewritable repeatability and low production cost, which provides a low-cost optical ultra-high density storage technology. new possibilities. On the other hand, compared with conventional fluorescent probes, probe materials with optical switch fluorescence characteristic...

Claims

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Application Information

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IPC IPC(8): C08F220/14C08F220/34C08F220/36C08F2/38C08F2/30C09K11/06
Inventor 陈建
Owner HUNAN UNIV OF SCI & TECH
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