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Stable amoxicillin tablet composition, as well as preparation method and application thereof

A technology of amoxicillin tablet and amoxicillin original drug, which is applied in the field of amoxicillin tablet composition, can solve the problems of shards, poor fluidity of powder, large difference in tablet weight, etc., and achieve reduced production, smooth and beautiful one-sided surface , the effect of reducing the incidence of allergic reactions

Inactive Publication Date: 2014-12-03
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Powder direct compression technology is a new preparation technology that has developed rapidly in recent years. The process is simple, but it has high requirements for the particle size distribution, particle shape, bulk density, fluidity, and compressibility of the powder. Poor performance, large discrepancy in tablet weight, and powder compression can easily cause cracks and other weaknesses

Method used

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  • Stable amoxicillin tablet composition, as well as preparation method and application thereof
  • Stable amoxicillin tablet composition, as well as preparation method and application thereof
  • Stable amoxicillin tablet composition, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] prescription:

[0047]

[0048] Preparation:

[0049] (1) Crushing the original drug of amoxicillin through a 100-mesh sieve;

[0050] (2) Weigh the pregelatinized starch and sodium carboxymethyl starch according to the above prescription, put them into a CH200 mixer and mix for 30 minutes, and pass through a 80-mesh sieve;

[0051] (3) Put the materials obtained in the above two steps into a V-shaped mixer, add the prescribed amount of micropowder silica gel and magnesium stearate, and mix for 30 minutes to fully mix the materials;

[0052] (4) The mixed material obtained from (3) is directly compressed into tablets to obtain amoxicillin tablets with a specification of 0.25 g per tablet.

Embodiment 2

[0054] prescription:

[0055]

[0056] Preparation method: prepare by referring to the method of Example 1.

Embodiment 3

[0058] prescription:

[0059]

[0060] Preparation method: prepare by referring to the method of Example 1.

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Abstract

The invention provides a stable amoxicillin tablet composition, as well as a preparation method and application thereof. The preparation process adopts a technology of directly tabletting powder. The amoxicillin tablet composition has the advantages that: the problems of amoxicillin tablet dissolution and product stability can be effectively solved, the influence of temperature and humidity on product quality can be avoided, generation of macromolecule impurities can be reduced, and the occurrence rate of anaphylactic reaction can be reduced, so that the clinical application safety can be improved, and the patient compliance can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a stable amoxicillin tablet composition, a preparation method and application thereof, and the preparation process adopts powder direct tableting technology. Background technique [0002] Amoxicillin, also known as amoxicillin, is the third-generation semi-synthetic broad-spectrum, acid-resistant penicillin. Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic Gram-negative bacteria that do not produce β-lactamase and Helicobacter pylori All have good antibacterial activity. Amoxicillin inhibits the synthesis of bacterial cell walls, causing them to quickly become spherical and rupture and dissolve, thus playing a bactericidal effect. Amoxicillin is convenient to take, has good curative effect, few adverse reactions and high safety. It is currently one of the most clinically used antibiotics with ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/43A61K47/38A61K47/36A61K47/26A61K47/04A61P31/04
CPCY02A50/30
Inventor 曾祎华张志兰李捷
Owner HAIKOU PHARMA FACTORY
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