Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical preparation for treating prosopalgia

A technology of pharmaceutical preparation and myrrh, applied in the field of traditional Chinese medicine, can solve the problems of high risk, difficult operation, difficult treatment, etc., and achieve the effects of low price and no toxic and side effects

Inactive Publication Date: 2014-12-24
杨桂菊
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease has a history of hundreds of years, but the etiology is still unclear, which brings great difficulties to the treatment
Over the years, many scholars have explored various methods, including conservative therapy with drug closure, craniotomy, radiofrequency heat therapy, bone cavity curettage for jaw lesions, trigeminal nerve avulsion and many other methods. Due to the high recurrence rate, Due to the low effective rate, high risk, difficult operation, and many complications, it cannot be widely used.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical preparation for treating prosopalgia

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] The present invention also provides a preparation method of the above-mentioned pharmaceutical preparation, when the dosage form of the pharmaceutical preparation is decoction, specifically:

[0052] The components of the raw materials are pulverized separately and mixed together to obtain a mixture, which is decocted twice by adding water, adding 3 to 5 times the mass of water relative to the mass of the mixture for the first time, decocting for 1 to 2 hours, filtering, and Add water 2 to 4 times the mass of the mixture to the filter residue, decoct for 1 to 2 hours, filter, mix the filtrates obtained from the two filtrations, and concentrate under reduced pressure to obtain a solution with a crude drug concentration of 1 g / ml.

[0053] The present invention also provides a preparation method of the above-mentioned pharmaceutical preparation, when the dosage form of the pharmaceutical preparation is an oral liquid, specifically:

[0054] In the first step, the componen...

Embodiment 1

[0057] The preparation of embodiment 1 decoction 1

[0058] Shouwu 40g, Selaginella 30g, Myrrh 35g, Vitex 25g, Ligusticum chuanxiong 40g, Oyster 30g, Dilong 20g, Fangfeng 25g, Acanthopanax 40g, Deergrass 20g, Licorice 25g, Angelica dahurica 30g, Nepeta 25g, 20g of Citrus aurantium, 20g of Baijiucao, 25g of Mulan, 20g of Ishimi Chuan, 20g of Magnolia officinalis, 30g of longan longan, 25g of celery and 40g of saffron, respectively crushed, mixed together to obtain a mixture, and boiled with water 2 times, add 2.5kg of water for the first time, decoct for 2 hours, filter, add 1.5kg of water to the filter residue again, decoct for 2 hours, filter, mix the filtrate obtained by two times of filtration, concentrate under reduced pressure, and obtain Decoction 1 with crude drug concentration of 1g / ml.

Embodiment 2

[0059] Embodiment 2 toxicology experiment

[0060] experimental drug

[0061] Mice were gavaged with decoction 1 prepared in Example 1 of the present invention.

[0062] Acute toxicity test in mice

[0063] The mice in the treatment group were administered according to the above method, each time 0.8ml / 10g, and the blank control group was given an equivalent amount of normal saline. For 14 consecutive days, the behavior, activity, food intake, body weight, feces, and death of the tested mice were recorded. The non-dead mice were sacrificed after 14 days for autopsy.

[0064] Drug preparation 80g (crude drug) / kg dosage administration mice, see that the mouse hair color is smooth, and ight soil is brown, texture is thinner and softer on the same day, and food intake, activity are less, after the 2nd day, mouse activity, food intake, weight gain, The feces and so on all returned to normal, and there was no significant difference compared with the blank control group; and no de...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a pharmaceutical preparation for treating prosopalgia. The pharmaceutical preparation comprises the following raw material medicines: vine of multiflower knotweed, Selaginella tamariscina, myrrh, fructus viticis, Ligusticum wallichii, oyster, earthworm, Divaricate Saposhnikovia Root, acanthopanax, Herba Pyrolae, liquorice, radix angelicae, Schizonepeta, immature bitter orange, Conyza japonica, Indigofera tinctoria, salvia chinensis, Mangnolia officinalis, fructus piperis longi, Cryptotaenia japonica and stigma croci. The pharmaceutical preparation has an obvious effect on treatment of prosopalgia, does not have any toxic or side effect and is low in price.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical preparation for treating trigeminal neuralgia. Background technique [0002] Trigeminal neuralgia is the most common clinical neurological disease in the field of oral surgery. It is a common painful disease. Most of the patients are middle-aged and elderly people, often accompanied by various chronic diseases. Due to limitations, the disease is more common in patients over 50 years old, and the incidence rate of women is higher than that of men. [0003] The disease is paroxysmal short-term severe pain after repeated appearances in the range of trigeminal nerve branches. Often accompanied by ipsilateral muscle twitching, no sensory deficit and other nerve conduction dysfunction. [0004] Modern medicine believes that trigeminal neuralgia is a demyelinating disease, and some scholars believe that it is a sensory epileptic seizure. The distr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P25/02A61K35/56
Inventor 不公告发明人
Owner 杨桂菊
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com