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Immunity promotion effect of branch houttuyfonate on swine fever cell activated vaccines and application

A technology for houttuyniacin and sodium houttuycin, which is applied to the preparation of branched-chain houttuycin solution, the application in the aspect of immune promotion of swine fever cell live vaccine, and the field of branched-chain houttuycin solution, which can solve the problem of It is easy to cause local reactions, the weak antigen of aluminum adjuvant is ineffective, and the effect is unstable.

Inactive Publication Date: 2015-01-07
SHANXI ZHAOYI BIOLOGICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used live cell vaccines for classical swine fever are highly safe, but their immunogenicity is weaker than that of swine fever baby rabbit vaccine and swine fever gonorrhea vaccine. Weak immunogenicity is also a common problem faced by modern vaccine technology. Cooperate with immune adjuvants and other means to overcome
[0003] There are many types of immune adjuvants commonly used at present, and they have certain effects, but there are some unavoidable shortcomings, such as Freund's adjuvant, adjuvant-65, white oil Span Adjuvants, MF-59 and other oil adjuvants are more viscous and have problems with local allergic reactions after injection; aluminum adjuvants have mild local reactions, cannot significantly induce cell-mediated immune responses, and are ineffective against weak antigens; Bacillus Calmette-Guerin (BCG) A large number of applications will cause serious side effects; some Chinese herbal medicines such as propolis, polysaccharides, Houttuynia cordata and compound Chinese herbal medicines have a certain immune adjuvant effect and have a good development prospect, but the immune enhancement effect of different degrees is low, unstable, Complex ingredients are likely to cause problems such as local reactions; other adjuvants are either expensive or unstable, which limits their application

Method used

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  • Immunity promotion effect of branch houttuyfonate on swine fever cell activated vaccines and application
  • Immunity promotion effect of branch houttuyfonate on swine fever cell activated vaccines and application
  • Immunity promotion effect of branch houttuyfonate on swine fever cell activated vaccines and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A branched chain houttuydine solution, comprising the following components, by weight percentage: 5% sodium propyl butyryl acetaldehyde sulfite; solubilizer: 40% hydroxypropyl cyclodextrin; pH buffering agent; stabilizer: Sodium bisulfite 0.02%, the balance is water.

[0037] The preparation method is as follows:

[0038] Weigh 5% sodium propyl butyryl acetaldehyde sulfite, 40% hydroxypropyl cyclodextrin and 20% water for injection, mix well, add 20% water for injection (containing 0.1% sodium bisulfite) and stir evenly; Phthalate buffer solution to adjust pH to 6.0; add water for injection to full amount; add 0.3% activated carbon and stir to remove pyrogen, decarbonize and filter; fine filter with 0.3 μm filter membrane, fill with nitrogen, sterilize, and send for inspection After passing the seal, it is sub-packaged, that is, the branched chain houttuyniatin solution.

Embodiment 2

[0040]A branched chain houttuydine solution, comprising the following components, by weight percentage: sodium methylbutyryl acetaldehyde sulfite 2%; solubilizer: Tween-80 20%; pH buffering agent; stabilizer: sulfurous acid Sodium hydrogen 0.2%, the balance is water.

[0041] The preparation method is as follows:

[0042] Weigh 2% sodium methylbutyryl acetaldehyde sulfite and 20% Tween-80 to fully mix; add 60% water for injection (containing 0.33% sodium bisulfite) and stir evenly; use citrate buffer Adjust the pH to 6.0; add water for injection to the full amount; add 0.3% activated carbon and stir to remove the pyrogen, decarbonize and filter; fine filter with a 0.3 μm filter membrane, fill with nitrogen and sterilize, and subpackage after passing the inspection. Streptatusin solution.

Embodiment 3

[0044] A branched chain houttuydine solution, comprising the following components, by weight percentage: sodium methylhexanoylglyoxal sulfite 1%; solubilizer: polyethylene glycol 30%; pH buffering agent; stabilizer: thio Sodium sulfate 0.5%, the balance is water.

[0045] The preparation method is as follows:

[0046] Weigh 1% sodium methylhexanoyl acetaldehyde sulfite, 30% polyethylene glycol and 20% water for injection and mix well; add 40% water for injection (containing 1.25% sodium thiosulfate) and stir evenly; use acetic acid-sodium acetate Adjust the pH of the buffer to 5.5; add water for injection to the full amount; add 0.3% activated carbon and stir to remove the pyrogen, decarbonize and filter; fine filter with a 0.3 μm filter membrane, fill with nitrogen, seal, sterilize, and subpackage after passing the inspection. That is, branched chain houttuyniatin solution.

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Abstract

The invention belongs to the technical field of veterinary medicines, particularly relates to a branch houttuyfonate solution, and also relates to a preparation method of the branch houttuyfonate solution and an application of the branch houttuyfonate solution to the immunity promotion effect on swine fever cell activated vaccines. The branch houttuyfonate solution comprises components in percentage by weight as follows: 0.5%-5% of branch sodium houttuyfonate, 1%-40% of a solubilizer, 1%-20% of a pH value buffer agent, 0.02%-2% of a stabilizer and the balance of water. The branch houttuyfonate solution is reasonable in design and has the advantages of good immunological enhancement effect, stability, simple component, unobvious local reaction and the like when being used as an immunologic adjuvant; besides, the preparation method of the branch houttuyfonate solution is simple, low in cost and very broad in market application prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a branched-chain houttuyniatin solution, a preparation method of the branched-chain houttuyniatin solution, and its application in promoting the immunity of swine fever cell live vaccines. Background technique [0002] There is no specific treatment for swine fever, which is listed as a first-class animal disease in my country. Vaccine prevention and emergency immunization are the main means to prevent and control swine fever. Currently commonly used live cell vaccines for classical swine fever are highly safe, but their immunogenicity is weaker than that of swine fever baby rabbit vaccine and swine fever gonorrhea vaccine. Weak immunogenicity is also a common problem faced by modern vaccine technology. Cooperate with immune adjuvants and other means to overcome. [0003] There are many types of immune adjuvants commonly used at present, and they have ce...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61P37/04
Inventor 赵鑫李逐波任鸿春
Owner SHANXI ZHAOYI BIOLOGICAL
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