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A kind of preparation method of sustained-release vitamin E derivative preparation

A vitamin and derivative technology, applied in the field of medicine and chemical industry, can solve problems such as no resistant starch, no slow-release vitamin E preparation, etc., and achieve the effects of being beneficial to absorption, reducing production costs and reducing costs.

Active Publication Date: 2017-10-17
ZHEJIANG NHU CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the published patented technologies, no reports of sustained-release vitamin E preparation technology with commercial promotion value have been found.
So far, there is no report on the application of resistant starch in the production of vitamin E products

Method used

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  • A kind of preparation method of sustained-release vitamin E derivative preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Add 100kg of dry corn starch and 150kg of water into the reactor, control the jacket temperature to 70°C, and the stirring speed to 200 rpm, add 10kg of 37% concentrated hydrochloric acid under the control of a metering valve, and hydrolyze for 15 minutes to obtain a part Hydrolyzed starch milk.

[0040] 2) Neutralize the partially hydrolyzed starch milk obtained in step 1) with 1% aqueous sodium hydroxide solution to a pH value of 7.5, then adjust the jacket temperature to 30°C, and the stirring speed to 100 rpm. Add 3 kg of octenyl succinic anhydride under control, and automatically add 1% aqueous sodium hydroxide solution to control the pH value of the reaction solution in the kettle at 7.5, and react for 120 minutes to obtain starch milk after esterification.

[0041] 3) Filtration, the filter cake was mixed with 100 kg vitamin E acetate, then ground for 2 hours, then transferred to a drying device.

[0042] 4) Steam is passed into the drying device to dry the g...

Embodiment 2

[0045] 1) Add 100kg of dry-based potato starch and 200kg of water into the reactor, control the jacket temperature to 40°C, and the stirring speed to 100 rpm, add 1kg of 37% concentrated hydrochloric acid under the control of a metering valve, and hydrolyze for 60 minutes to obtain partial hydrolysis After the starch milk.

[0046] 2) Neutralize the partially hydrolyzed starch milk obtained in step 1) with sodium hydroxide to a pH value of 9.0, then adjust the jacket temperature to 50°C, and the stirring speed to 200 rpm, and add 0.5 kg of Octenyl succinic anhydride, and automatically control the addition of sodium hydroxide to control the pH value of the reaction solution in the kettle at 9.0, and react for 60 minutes to obtain starch milk after esterification.

[0047] 3) Filtration, the filter cake was mixed with 100kg vitamin E acetate, then ground for 0.5 hours, then transferred to a drying device.

[0048] 4) Steam is fed into the drying device to dry the ground product...

Embodiment 3

[0051] 1) Add 100kg of dry waxy cornstarch and 160kg of water into the reaction kettle, control the jacket temperature to 50°C, and the stirring speed to 150 rpm, add 2kg of 37% concentrated hydrochloric acid under the control of a metering valve, and hydrolyze for 30 minutes to obtain part Hydrolyzed starch milk.

[0052] 2) Neutralize the partially hydrolyzed starch milk obtained in step 1) with sodium hydroxide to a pH value of 8.0, then adjust the jacket temperature to 40°C, and the stirring speed to 150 rpm, and add 2.5 kg of Octenyl succinic anhydride, and automatically control the addition of sodium hydroxide to control the pH value of the reaction solution in the series tank at 8.0, and react for 90 minutes to obtain starch milk after esterification.

[0053] 3) Filtration, the filter cake was mixed with 100 kg vitamin E acetate, then ground for 1.5 hours, then transferred to a drying device.

[0054] 4) Steam is passed into the drying device to dry the ground product...

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PUM

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Abstract

The invention discloses a slow-release vitamin E derivative preparation and a preparation method thereof. The steps are: mix dry base starch and water, add concentrated hydrochloric acid to obtain partially hydrolyzed starch milk; add octenyl succinic anhydride and sodium hydroxide to partially hydrolyzed starch milk to obtain esterified starch milk ; Filtration, mixing the filter cake with vitamin E derivatives, grinding, high-temperature drying and low-temperature treatment, and finally obtaining slow-release vitamin E derivative preparations. The present invention uses low-cost native starch as a raw material to prepare vitamin E derivative preparations. Not only does the raw material cost have competitive advantages and the biocompatibility is significantly better than that of silica, but also the resistant starch content of the coating material is significantly increased to achieve slow release effect.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation method of a slow-release vitamin E derivative preparation. Background technique [0002] Vitamin E (V E ) was discovered as early as 1920. Because its function is related to fertility, it is also called tocopherol. It is a derivative of phenylpropanedihydrofuran. Currently, 8 species are known, of which α-tocopherol has the highest physiological activity. Vitamin E is an indispensable fat-soluble vitamin for human beings. It has the functions of anti-oxidation, anti-sterility, and enhancing the body's immunity. It is stable against heat, acid, and alkali in the absence of oxidants, and it is easily oxidized into quinones. Class; stable to visible light, but can be destroyed by ultraviolet light; relatively stable in acidic environment and after esterification. [0003] Most of the vitamin E currently on the market is α-tocopherol. Due to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K31/355A61K9/14A61P3/02C08B31/04
Inventor 仇丹陈志荣石立芳张其磊田李嘉
Owner ZHEJIANG NHU CO LTD
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