Flupentixol and melitracen pharmaceutical composition and preparation method thereof

A technology of melitracen and flupentixol, which is applied in the field of pharmaceutical preparations, can solve the problems of poor fluidity and compressibility, etc., and achieves the effects of avoiding the wet-heat drying process, and having good production process reproducibility and stability.
CN104288153AActive
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)

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Abstract

The invention relates to a tablet composition of antidepressant flupentixol and melitracen and a preparation method of the tablet composition. The composition comprises flupentixol (the particle size distribution D90 is smaller than 150mu m), melitracen, a filling agent, a disintegrating agent, an adhesive and a lubricating agent. The tablet composition is prepared from full-powder in a direct tabletting manner; and the method comprises the following steps: mixing step by step; tabletting; and coating and the like. The manufacturing process is simple; pelletizing and drying are avoided; energy and time are saved; the stability of active components is protected; the disintegration property and the dissolution rate of the tablet are improved; and the prepared tablet composition of antidepressant flupentixol and melitracen is stable in quality, low in impurity content, safe and good in effectiveness.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a flupentixol melitracen pharmaceutical composition and a preparation method thereof. Background technique

[0002] Flupentixol (flupentixol) is a thiaxanthene atypical antipsychotic drug, which acts by blocking dopamine receptors in the mesencephalic-limbic system and midbrain-cortical system. Its chemical name is: α-trifluoromethyl- 9-{3-[4-(2-Hydroxyethyl)-1-diethylenediamine]-propane}-thioxanthene, the structure is shown in formula Ⅰ:

[0003]

[0004] Melitracen (melitracen) is a tricyclic (heterocyclic) antidepressant drug that inhibits the reuptake of norepinephrine and serotonin and increases the concentration of these two transmitters in the synaptic cleft. Its chemical name is: 3-[10,10-dimethyl-9(10H)-anthracene]-N,N-dimethyl-1-propanamine, and its structure is shown in formula II:

[0005]

[0006] Because flupenthixol may produ...

Claims

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