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A three-dimensional porous fiber scaffold, preparation method and application

A fiber scaffold and three-dimensional porous technology, which is applied in the field of three-dimensional porous fiber scaffold, medical materials and its preparation, and can solve the problems of unstudied tensile mechanical properties, low tensile strength and elongation rate, low CPC strength, etc. problems, to achieve good expandability, improve conductivity, fine fiber diameter effect

Inactive Publication Date: 2016-03-30
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the bone cement material required in PKP surgery, CPC still has two serious defects: first: under the condition of 100% humidity, the curing reaction is relatively slow, and it is easy to collapse in the early stage; second: the initial strength of CPC is relatively low
However, these research results show that the tensile strength and elongation ratio are relatively low, and there is no systematic investigation of the effect of solvent on the tensile mechanical properties of the prepared materials.

Method used

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  • A three-dimensional porous fiber scaffold, preparation method and application
  • A three-dimensional porous fiber scaffold, preparation method and application
  • A three-dimensional porous fiber scaffold, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take by weighing 4g of P3HB4HB, wherein the molar content of 4HB is 18%, slowly adding the weighed P3HB4HB to the mixed solvent of 46g of chloroform and acetone mass fraction ratio is 75:25, about 4 under the condition of magnetic stirring Hour, can obtain the solution that polymer concentration is 8wt%. Then transfer the polymer solution to a 10ml glass syringe and place it in an electrospinning device. By adjusting the voltage to 10kV, the extrusion rate is 3ml / h, and the distance from the needle to the receiving device is 14cm, fibers can be obtained under this condition Fiber membrane with uniform diameter distribution and good shape. When the fiber membrane reaches 50 μm, the spinning process is stopped, and the fiber membranes are collected directly with a glass rod, and this process is repeated 3 times to increase the thickness of the scaffold wrapped on the glass rod, and the thickness can be controlled by the number of repetitions. Wrap the obtained scaffold w...

Embodiment 2

[0035] Weigh 4g of P3HB4HB, wherein the molar content of 4HB is 18%. Slowly add the weighed P3HB4HB into 46g of chloroform solvent for about 4 hours under the condition of magnetic stirring to obtain a solution with a polymer concentration of 8wt%. Then transfer the polymer solution to a 10ml glass syringe and place it in the electrospinning device. By adjusting the voltage to 10kV, the extrusion rate is 3ml / h, and the distance from the needle to the receiving device is 14cm, fibers can be obtained under these conditions Fiber membrane with uniform diameter distribution and good shape. The fibrous membrane obtained under this condition could not be successfully collected on the glass rod, and the three-dimensional elastic scaffold could not be successfully prepared.

Embodiment 3

[0037] The P3HB4HB that takes 4g, wherein the molar content of 4HB is 18%, slowly the P3HB4HB that weighs is added to the mixed solvent that the chloroform of 46g and acetone mass fraction ratio are 50:50, about 4 under the condition of magnetic stirring Hour, can obtain the solution that polymer concentration is 8wt%. Then transfer the polymer solution to a 10ml glass syringe and place it in an electrospinning device. By adjusting the voltage to 10kV, the extrusion rate is 3ml / h, and the distance from the needle to the receiving device is 14cm, fibers can be obtained under this condition Fiber membrane with uniform diameter distribution and good shape. When the fiber membrane reaches about 50 μm, the spinning process is stopped, and the fiber membrane is collected directly with a glass rod, and this process is repeated 3 times to increase the thickness of the scaffold wrapped on the glass rod, and the thickness can be controlled by the number of repetitions. Wrap the obtaine...

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Abstract

The invention discloses a three-dimensional porous fibrous skeleton as well as a preparation method and application of the three-dimensional porous fibrous skeleton. The three-dimensional porous fibrous skeleton is prepared by virtue of the following steps: dissolving poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in the mixed solution of chloroform and acetone to obtain a spinning solution in which the concentration of the polymer is 6wt%-12wt%; collecting on a tin foil by virtue of an electrostatic spinning process to obtain a fibrous membrane, winding the fibrous membrane by use of a glass rod, and unwinding the fibrous membrane from the glass rod after drying and flushing with ethanol, thereby obtaining the three-dimensional expansible porous fibrous skeleton. The three-dimensional porous fibrous skeleton has excellent biodegradability, biocompatibility and elastic property; when the three-dimensional porous fibrous skeleton is applied to the operative treatment of vertebral compression fracture caused by osteoporosis as a sacculus, the problems of bone cement leakage and easy collapse of calcium phosphate bone cement under 100% humidity can be effectively solved; as a result, the three-dimensional porous fibrous skeleton plays an important role in reducing the risk of the percutaneous kyphoplasty and popularizing and utilizing the calcium phosphate bone cement.

Description

technical field [0001] The invention relates to a medical material and a preparation method thereof, in particular to a three-dimensional porous fiber support with high elastic performance, a preparation method and an application thereof, belonging to the technical field of functional fiber materials. Background technique [0002] As the social population structure tends to age, vertebral compression fracture (vertebral compression fracture, VCF) caused by osteoporosis has become a common cause of disease and death in the elderly. Currently, the main means of treating vertebral compression fractures caused by osteoporosis are percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP). Compared with PVP, in addition to increasing the strength of the vertebral body and stabilizing the vertebral body, PKP also restores a certain height of the vertebral body. Therefore, PKP has been widely carried out and widely used clinically. But in clinical use, bone ceme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14
Inventor 高春霞高强杨磊
Owner SUZHOU UNIV
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