Policresulen suppository

Abstract

The invention discloses a policresulen suppository. The suppository is prepared from policresulen, polyoxyethylene and polyoxyl (40) stearate. Compared with the prior art, the policresulen suppository is capable of solving the problems of policresulen degradation and suppository oil leakage; and the production process is simple, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a policresulen suppository. Background technique [0002] Policresulen and its preparations were first developed by the German Baxton Pharmaceutical Factory, and imported in 1993. Aibao therapy has been included as a national essential drug. Policresulen is a topical hemostatic and bactericide, which has a strong killing effect on pathogens. It is mainly used in gynecology, surgery, dermatology, and otolaryngology in clinical practice. Its advantage is that it does not damage normal tissues. [0003] Policresulen is a strong acid substance, and its mechanism of action is to kill bacteria, trichomonas, molds and other pathogenic microorganisms through strong acid and protein coagulation; it can selectively act on diseased epithelial cells and ectopic columnar cells. Epithelium, coagulates, degenerates, falls off, and promotes tissue repair, causes vasoconstriction an...

AI Technical Summary

Problems solved by technology

However, the disadvantages of current suppositories are that they are easy to melt and flow out, have a greasy feeling, and have a burning sensation after application; the concentrated solution must be diluted with water before use, and it is difficult to ensure the accuracy of the solution concentration during the dilution process, and it is easy to contaminate clothes. and bedding; the gel needs to be coated on the inner surface of the vagina by means of a coating device. Although the preparation has good adhesion on the surface of the vaginal mucosa, it is difficult to ensure that the coating is even, and it is prone to dead ends (such as vaginal vaults). Department), more importantly, it is inconvenient to administer

[0006] CN102824358A discloses a polycresol compound suppository, which uses soybean lecithin and mixed fatty acid glyceride as the suppository base, has a low melting point, and is easy to flow out from the body after melting, making it inconvenient to use

[0007] CN101919807A discloses a suppository composition with improved properties, which uses high molecular weight polyoxyethylene as the base, but also requires other aliphatic bases and alcohols to be used in conjunction. When filling high molecular weight polyoxyethylene alone, the base Viscous and inconvenient to fill

[0008] CN1771989A discloses a compound preparation for the treatment of gynecological inflammation, using glycerin gelatin, polyethylene glycol, polyoxyethylene 40 stearate and cocoa butter etc. Inconvenience, and the corresponding side effects will increase

[0009] CN103181889A and CN103520087A disclose the preparation technology of polycresol sulfonal expansion suppository, the drug-containing matrix of the expansion suppository is in full contact with the vaginal wall, and the bioavailability of the active drug is improved, but the expansion material absorbs water and physically expands, which is slow to absorb water and can absorb a large amount of Liquid medicine; swelling material absorbs water and swells, causing vaginal dryness, discomfort, and increased foreign body sensation

Even if the tail end is cut off in CN103520087A, the swelling sliver and other elastic fibers will not expand regularly, and cannot be well attached to the vaginal epithelium and mucous membrane, and the effect of solving the side leakage of the medicinal liquid is not ideal

The tail ends of these expansion bolts are drawn with ropes, which also brings discomfort to the patient.

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