Process for preparing high-optical-purity R-(+)-2-chloropropionic acid through ester exchange method
A technology of chloropropionic acid and transesterification, which can be applied in the preparation of carboxylate, carboxylate/lactone, and oxygen-containing compounds, etc., can solve the problems of high production cost, many chiral impurities, hindering the progress of the reaction, and the like, To achieve the effect of short production cycle, good catalytic effect and reduction of tailings
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0017] ⑴ Add 600g of ethyl chloropropionate into the reactor equipped with stirring, thermometer, spherical condenser, electric heating mantle, and tail gas absorption device, turn on the stirrer, and add 1200g with a mass fraction of 94% under stirring conditions. 180g of formic acid and 732 resin treated with acid and alkali, slowly increase the temperature to 54°C, and collect the ethyl formate fraction; when the mass of the collected ethyl formate fraction is about 300g, continue to increase the temperature and collect the 85°C~108°C fraction. The distillate is mainly formic acid; after the reaction, the material and the resin are filtered and separated, and the resin is returned to the system for the next hydrolysis separation process, which is recycled and reused.
[0018] ⑵Connect the reactor to a vacuum pump, evacuate and reduce pressure to -0.095MPa~-0.01MPa, start to heat up, and collect the fraction below 108°C. This fraction is divided into unreacted ethyl chloropropio...
Embodiment 2
[0020] ⑴Add 700g of ethyl chloropropionate into the reactor equipped with stirring, thermometer, spherical condenser, electric heating mantle, and exhaust gas absorption device, turn on the stirrer, add 1050g respectively, with a mass fraction of 94% under stirring 210g of formic acid and D001 strongly acidic cationic resin treated with acid and alkali, slowly increase the temperature to 54℃, and collect the ethyl formate fraction; when the mass of the collected ethyl formate fraction is about 350g, continue to increase the temperature and collect 85℃~108℃ Fraction, this fraction is mainly formic acid; after the reaction, the material and the resin are filtered and separated, and the resin is returned to the system for the next hydrolysis and separation process, which is recycled and reused.
[0021] (2) Connect the reactor to a vacuum pump, evacuate and reduce pressure to -0.095MPa~-0.01MPa, start to heat up, collect fractions below 108°C, this fraction is divided into unreacted ...
Embodiment 3
[0023] ⑴Add 400g of ethyl chloropropionate into the reactor equipped with stirring, thermometer, spherical condenser, electric heating mantle and tail gas absorption device, turn on the stirrer, and add 1600g of 94% mass fraction under stirring conditions. 240g of formic acid and 734 strongly acidic cationic resin treated with acid and alkali, slowly increase the temperature to 54°C, and collect ethyl formate fraction; when the collected ethyl formate fraction is about 200g, continue to increase the temperature and collect the 85°C~108°C fraction , This fraction is mainly formic acid; after the reaction, the material and the resin are filtered and separated, and the resin is returned to the system for the next hydrolysis and separation process, which is recycled and reused.
[0024] ⑵Connect the reactor to a vacuum pump, evacuate and reduce pressure to -0.095MPa~-0.01MPa, start to heat up, and collect the fraction below 108°C. This fraction is divided into unreacted ethyl chloropr...
PUM
Property | Measurement | Unit |
---|---|---|
specific rotation | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com