A kind of autumn eggplant leaf total flavonoid nanoemulsion and its gel for whitening and freckle removal

A technology for whitening and removing freckles and autumn eggplant leaves, which is applied in the field of total flavonoid nanoemulsion of autumn eggplant leaves and its gel, can solve the problems of difficult nanoemulsion, poor solubility in water phase and oil phase, etc., and achieves inhibition of melanin production and inhibition of tyrosine. Acidase activity, the effect of improving curative effect

Active Publication Date: 2017-06-06
廖霭华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the Chinese invention authorized patent No. ZL200910037765.1 also mentions that the external freckle-removing cosmetics are prepared as nanoemulsions. Monomer components, natural plant extracts are mostly mixtures of multiple components, especially ethanol extracts with a certain concentration, often have poor solubility in water and oil phases, making it difficult to make nanoemulsions

Method used

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  • A kind of autumn eggplant leaf total flavonoid nanoemulsion and its gel for whitening and freckle removal
  • A kind of autumn eggplant leaf total flavonoid nanoemulsion and its gel for whitening and freckle removal
  • A kind of autumn eggplant leaf total flavonoid nanoemulsion and its gel for whitening and freckle removal

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: prepare the high-purity candela leaf total flavonoids used in the present invention

[0051] (1) Extraction: take candela leaves and crush them into coarse powder, take 1000g, use ethanol with a volume fraction of 60% as the extraction agent, the ratio of solid to liquid is 1: 15 (mass volume ratio), the extraction temperature is 80 ℃, the extraction time is 0.5 h, and the 2 times.

[0052] (2) Separation and purification: Purify the total flavonoids of candela leaves obtained in step (1) with HPD722 macroporous adsorption resin. The specific purification process is: the concentration of total flavonoids in the sample is 5.0mg / mL, and the flow rate of the sample is 3BV / h. The sample loading volume is 6.5 BV resin column volume, the adsorption time is 30 min, the impurities are washed with 3.5 BV water, the eluent is ethanol with a volume fraction of 50%, the elution flow rate is 3BV / h, and the amount of eluent is 4 BV resin column volume, collected the et...

Embodiment 2

[0053] Embodiment 2: Preparation of high-purity candela leaf total flavonoids used in the present invention

[0054] (1) Extraction: take candela leaves and crush them into coarse powder, take 1000g, use ethanol with a volume fraction of 70% as the extractant, the ratio of solid to liquid is 1: 15 (mass volume ratio), the extraction temperature is 70°C, the extraction time is 0.5 h, and the extraction 2 times.

[0055] (2) Separation and purification: the total flavonoids of candela leaves obtained in step (1) were purified with HPD100 macroporous adsorption resin. The loading volume is 6BV resin column volume, the adsorption time is 30 min, and the impurity is washed with 4BV water, the eluent is ethanol with a volume fraction of 80%, the elution flow rate is 6BV / h, and the eluent dosage is 4 BV resin column volume , collected the ethanol liquid, recovered the solvent under reduced pressure, vacuum dried, and pulverized to obtain 93.2 g of total flavonoid powder of yellow-br...

Embodiment 3

[0056] Embodiment 3: Preparation of high-purity candela leaf total flavonoids used in the present invention

[0057] (1) Extraction: take candela leaves and crush them into coarse powder, take 1000g, use ethanol with a volume fraction of 65% as the extractant, the ratio of solid to liquid is 1: 15 (mass volume ratio), the extraction temperature is 78°C, the extraction time is 0.5 h, and the extraction 2 times.

[0058] (2) Separation and purification: Purify the total flavonoids of candela leaves obtained in step (1) with HPD826 macroporous adsorption resin. The specific purification process is: the concentration of total flavonoids in the sample is 4.0mg / mL, and the flow rate of the sample is 3BV / h. The sample loading volume is 7BV resin column volume, the adsorption time is 30 min, the impurity is removed by washing with 3BV water, the eluent is ethanol with a volume fraction of 35%, the elution flow rate is 3BV / h, and the eluent dosage is 4 BV resin column volume , collect...

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Abstract

The invention relates to a kandelia candel leaf total flavonoid nano-emulsion for whitening the skin and removing freckles and a gel thereof. The nano-emulsion consists of the following components in parts by weight: 0.3-0.65 part of kandelia candel leaf total flavonoid, 2.5-5 parts of an oil phase, 1.4-6 parts of an emulsifying agent, 1.4-6 parts of a co-emulsifier and 40-160 parts of water; the average particle size of the kandelia candel leaf total flavonoid nano-emulsion is less than or equal to 100nm; and the gel consists of the following components in percentage by weight: 0.2-0.8% of a gel skeleton material, 2-8% of glycerin and the balance of the kandelia candel leaf total flavonoid nano-emulsion. The kandelia candel leaf total flavonoid nano-emulsion and the gel thereof, disclosed by the invention, adopt kandelia candel leaf total flavonoid with high purity as an active component for the first time, also have the abilities of inhibiting melanogenesis, inhibiting the activity of tyrosinase, resisting oxidation and resisting ultraviolet rays, and can play good roles in whitening the skin and removing the freckles without adding other components; and the kandelia candel leaf total flavonoid nano-emulsion and the gel thereof are good in stability, and cannot have lamination phenomena in processes of centrifugation and high-temperature and low-temperature tests.

Description

technical field [0001] The invention relates to a candela leaf total flavonoid nanoemulsion and a gel thereof for whitening and removing freckles, and belongs to the technical field of cosmetics and its preparation. Background technique [0002] Skin hyperpigmentation is a common multiple skin disease. Including chloasma, age spots, freckles, etc. The main causes of skin melanosis are endocrine disorders and weakened metabolism. Secondly, sun exposure, ultraviolet radiation, and lack of sleep will aggravate pigmentation. Whitening and freckle-removing ingredients for external skin use mainly in the following ways: inhibiting the synthesis and activity of tyrosinase, reducing skin pigmentation, chemical peeling, and reducing the negative effects of exogenous factors such as ultraviolet rays and oxygen free radicals on the physiological process of melanin formation . At present, cosmetics for whitening and removing freckles mostly consist of a combination of ingredients with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/06A61K8/04A61K8/81A61Q19/02
Inventor 李成平唐岚饶桂维姜燕清计燕萍严小平活泼
Owner 廖霭华
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