A kind of 7-azaisatin double spiro compound with antitumor activity and its synthesis method

A technology of compound and heteropolyacid, which is applied in the field of medicine, can solve problems such as treatment failure, and achieve the effect of less steps, high yield and good anti-tumor activity
CN104402886BActive Publication Date: 2017-01-25SHENYANG HONGQI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENYANG HONGQI PHARMA
Publication Date
2017-01-25

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Abstract

The invention relates to a 7-aza isatin nuclear parent-containing dispirocyclic compound with antitumor activity and shown as a structural formula (I) and a synthetic method thereof. The dispirocyclic compound is synthesized from raw materials of pulegone, 7-aza isatin and its derivatives, and sarcosine through a one-pot synthesis process; and the process avoids complicated multi-step operation, and has the advantages of mild reaction condition and good yield. Biological activity tests show that the 7-aza isatin nuclear parent-containing dispirocyclic compound has good antitumor activity and broad application prospects in the field of medicine.
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Description

technical field

[0001] The invention relates to a class of double spiro compounds containing a 7-azaisatin mother nucleus and a synthesis method thereof, belonging to the technical field of medicine. Background technique

[0002] Tumor is a disease that seriously threatens human health, and tumor is essentially a genetic disease. DNA damage induced by various environmental and genetic carcinogens in a coordinated or sequential manner, resulting in the activation of proto-oncogenes and / or the inactivation of tumor suppressor genes, coupled with alterations in apoptosis-regulating genes and / or DNA repair genes , and then cause abnormal expression levels, transform target cells, and form malignant tumors, mainly due to unreasonable diet, genetic factors, environmental factors, etc. The mechanism of action of anti-tumor drugs and the targets of drugs are various, and the multi-drug resistance of tumor cells often leads to the failure of treatment. Finding effective and safe an...

Claims

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