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A traditional Chinese medicine composition with anti-inflammatory and hemostatic effect

A technology of nude flower purple beads, anti-inflammatory and hemostasis, which is applied in the direction of drug combinations, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of large doses, unacceptable quality standards, poor controllability of quality standards, etc., and achieve effective Definite substances, few side effects, and definite curative effects

Active Publication Date: 2016-01-20
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are disadvantages such as large doses, unclear active ingredients, and poor controllability of quality standards, making it difficult to meet the requirements of "safe, effective, controllable, and stable" drugs
At present, although there are a variety of dosage forms that are convenient for patients to use, they are only simple dosage form conversions, and there is no substantial innovation in technology. Accepted by the international market

Method used

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  • A traditional Chinese medicine composition with anti-inflammatory and hemostatic effect
  • A traditional Chinese medicine composition with anti-inflammatory and hemostatic effect
  • A traditional Chinese medicine composition with anti-inflammatory and hemostatic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of each effective part of embodiment 1 nude flower purple pearl

[0017] Preparation of triterpenoids of Auranthus nudica: Take 5 kg of Auranthus nudica medicinal material, reflux extraction with 40 L of 75% ethanol for 3 times, extract for 1 hour each time, recover the solvent under reduced pressure, obtain the extract, add a certain volume of water to disperse and dissolve , so that the volume ratio of the amount of medicinal material to the solution after dispersion is 1:10. Then centrifuge at a speed of 4000 rpm for 30 minutes, pour out the supernatant, add 95% ethanol 7 times the amount of the crude drug to disperse the precipitate, and centrifuge for 30 minutes at a speed of 3000 rpm. After centrifugation, the solvent was recovered from the supernatant to dryness, and vacuum-dried to obtain 105 g of Adenophora triterpenoids.

[0018] Preparation of total flavonoids of Auranthus nudica: Take 5kg of Auranthus nudica, add 100kg of ketone, soak for 40...

Embodiment 2-5

[0020] The preparation of embodiment 2-5 Chinese medicine composition

[0021] Mix the effective fractions prepared in Example 1 according to the ratio in the table below.

[0022] (％) Example 2 Example 3 Example 4 Example 5 Total flavonoids of naked flower purple pearl 10 30 50 80 Effective parts of tannin 10 40 30 10 Triterpenoids from Adenophora nudiflora 80 30 20 10

Embodiment 6

[0023] Embodiment 6 pharmacodynamic experiment

[0024] (1) Effect on coagulation time of mice (capillary glass tube method)

[0025] At a room temperature of 15°C, ICR mice, weighing 18-22 g, male and female, were randomly divided into 4 groups, 10 mice in each group. Intragastric administration, the blank control group was given the same volume of saline, 1 time / day, continuous administration for 7 days, 1h after the last administration, the mouse was fixed with a clip, and a capillary glass tube with an inner diameter of 1mm (or one-time quantitative blood vessel ) into the venous plexus behind the medial canthus of the mouse to take blood, the depth is about 4-5mm, rotate gently, and then retract. Start timing from the time when the blood flows into the tube. After the blood is full, take out the capillary tube and place it flat on the table. Every 30 seconds, break off a short section of the capillary tube about 0.5 cm from both ends, and slowly pull it away to the left ...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and particularly relates to traditional Chinese medicine composition containing callicarpa nudiflora. Ingredients of the composition are from callicarpa nudiflora and specifically comprise, in percentage by weight, 10%-80% of total flavonoids of callicarpa nudiflora, 10%-80% of effective tannin parts of callicarpa nudiflora and 10%-80% of triterpenoid of callicarpa nudiflora. Preferably, the traditional Chinese medicine composition comprises, in percentage by weight, 20%-50% of total flavonoids of callicarpa nudiflora, 30%-50% of effective tannin parts of callicarpa nudiflora and 20%-30% of triterpenoid of callicarpa nudiflora.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a composition of Auranthus nudiflora components and a preparation method thereof. Background technique [0002] Callicarpanudiflora (Callicarpanudiflora Hook. et Arn.) is a plant of the genus Verbenaceae (Verbenaceae). It is mainly produced in Hainan, my country. It is an authentic medicinal material in Hainan, and it is also distributed in Guangdong and Guangxi. At present, studies have shown that the main components of Auranthus nudica are flavonoids, tannins, terpenoids, and volatile oils, among which terpenoids and flavonoids can increase the number of platelets, shorten bleeding and coagulation time, and have a significant effect on the fibrinolytic system. Inhibition, blood vessel constriction, hemostasis effect is remarkable, it has obvious inhibitory effect on exudation and swelling in the early stage of inflammation, accelerates the absorption of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61P29/00A61P7/04
CPCA61K36/85A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 肖军平吴永忠李小锋杨伟庆毛金娣
Owner JIANGXI POZIN PHARMA
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