A kind of preparation technology of chondroitin sulfate calcium salt
A kind of chondroitin sulfate calcium, the technology of preparation technology, is applied in the preparation field of chondroitin sulfate calcium salt, can solve the problems such as loss of chondroitin sulfate, cost increase, low yield, achieve shortening process time, avoid sewage discharge, process consumption The effect of duration
Active Publication Date: 2017-01-11
MEITEK TECH QINGDAO
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Problems solved by technology
This method has two major disadvantages. One is that about 20% of the chondroitin sulfate sodium salt will be lost after redissolving, which greatly increases the cost. The other is that the whole process takes a long time and there is a risk of material corruption.
[0011] Chinese patent CN 102816809A "a preparation process of chondroitin sulfate calcium salt" discloses that the preparation process of chondroitin sulfate calcium salt includes water cooking, alkaline hydrolysis extraction, enzymatic hydrolysis, adsorption and washing, elution, decolorization, precipitation and drying and other steps can be directly extracted from animal cartilage to prepare chondroitin sulfate calcium, but adding sodium-containing substances in the process requires resin transformation, and the resin transformation method causes chondroitin sulfate loss during the elution process; moreover, the process Hydrogen peroxide needs to be used for decolorization, and hydrogen peroxide is used as a disinfectant, which has been removed from the "GB 2760-2011 Standards for the Use of Food Additives". It cannot be added at will during production, and there is a food safety risk; finally, the overall process takes a long time and the yield is low.
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Embodiment 1
[0041] The production process of chondroitin sulfate calcium salt is as follows:
[0042] 1) Feed 1.5 tons of pig nose bones into the reactor, then inject 5-6 times the volume of pure water to stir and clean the raw cartilage until the surface is free of dirt, and drain the cleaning water; use pure water to prevent other ion contamination, and at the same time wash off the cartilage surface blood stains.
[0043] 2) Then add pure water at 60-70°C according to the ratio of 1:8-10 of dry cartilage, soak and rehydrate for 3-4 hours. After rehydration, the cartilage enters the pulverizer and colloid mill in turn to obtain a uniform bone pulp; after rehydration with hot water, the cartilage becomes brittle and plump, and is easy to crush and process. After crushing, the specific surface area of the raw material increases, which increases the contact opportunity between the material and the enzyme , helps to accelerate enzymatic hydrolysis.
[0044] 3) The bone pulp is transport...
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The invention relates to the preparation of chondroitin sulfate, and in particular relates to a preparation process of calcium chondroitin sulfate salt. The preparation process comprises the following steps: pretreatment, enzymolysis, ultra-filtration, alcohol precipitation, alcohol washing and drying. According to the preparation process disclosed by the invention, resin transformation is not needed, and hydrogen peroxide does not need to be added for corrosion prevention or decoloration; the preparation process is simple and fast in procedure and low in investment cost, and can be used for extracting a calcium chondroitin sulfate salt product with excellent quality from animal cartilages; and meanwhile, a high extraction rate can be ensured, and the extraction rate of the preparation process disclosed by the invention is 20-30% higher than that of a transformation method.
Description
technical field [0001] The invention relates to the preparation of chondroitin sulfate, in particular to a preparation process of chondroitin sulfate calcium salt. Background technique [0002] Chondroitin Sulfate (Chondroitin Sulfate, CS) is an acidic mucopolysaccharide that exists in the connective tissue of humans and animals. It belongs to a kind of sulfated glycosaminoglycans. A group of heterogeneous linear polysaccharides composed of disaccharide repeating units, with a relative molecular mass of 10,000 to 50,000, mainly distributed in cartilage, tendons, fascia, and blood vessel walls such as the laryngeal bone, nasal septum, and trachea. [0003] CS has obvious pro-chondrogenicity and can preferentially enter cartilage tissue to protect cartilage. In 2003, the European Federation for the Prevention and Treatment of Rheumatism published recommendations for the treatment of knee osteoarthritis (osteoarthritis, OA) that CS is an effective drug for the treatment of kne...
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IPC IPC(8): C08B37/08
Inventor 张亮
Owner MEITEK TECH QINGDAO