Mildew preventive and application thereof

A technology of antifungal agent and auxiliary agent, which can be used in applications, biocides, disinfectants, etc., and can solve problems such as safety doubts, poor compatibility, and high price.

Active Publication Date: 2015-04-01
宁夏万厚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional high-temperature antifungal agents on the market have certain defects. OBPA has a good anti-mold effect and high temperature resistance, but it is an arsenic-containing compound, and there are certain doubts about its safety; IP

Method used

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  • Mildew preventive and application thereof
  • Mildew preventive and application thereof
  • Mildew preventive and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, antifungal activity assay

[0035] In this example, Aspergillus niger, Aspergillus flavus, Penicillium citrinum, Escherichia coli, Bacillus megaterium, Staphylococcus aureus, etc. were used as experimental objects to test single-component tebuconazole, 4,5-dichloro-2-n- Minimum inhibitory concentrations of octyl-3-isothiazolinone (DCOIT), and a mixture of tebuconazole and DCOIT (mixing ratio 3:1).

[0036] The test method is as follows:

[0037] 1. Preparation of samples with different concentrations:

[0038] Accurately measure 97% of the original drug of tebuconazole, 97% of the original drug of DCOIT and [tebuconazole (in percent): 4,5-dichloro-2-n-octyl-3-isothiazolinone (in percent)= 3:1] mixture, using methanol as a solvent to prepare the volume concentration of 0.5% tebuconazole, 0.5% DCOIT and 0.5% tebuconazole and DCOIT mixture, and then use them as the initial solution and dilute them in sequence with methanol , so as to obtain a series of sam...

Embodiment 2～13

[0052] Embodiment 2~13, the preparation of antifungal agent

[0053] Configure the antifungal agent according to the ingredients and ratios listed in Table 2:

[0054] Table 2, antifungal agent composition and ratio

[0055]

[0056] Preparation method: Stir and mix tebuconazole, DCOIT and additives in proportion to obtain plastic antifungal agent.

Embodiment 18

[0057] Embodiment 18, antifungal agent to the antifungal test of polypropylene PP and polyvinyl chloride PVC

[0058] In this embodiment, the antifungal agent samples obtained in Examples 2 to 17 are taken as examples to test their antifungal activity.

[0059] A) Samples for testing

[0060] ①In the process of injection molding of polypropylene (PP) products, antifungal agents are added to make the final polypropylene products have antibacterial and antifungal functions, that is, using an injection molding machine, injection molding at an injection molding temperature of 220°C and cutting into 50mm×50mm The final product contains about 0.5% anti-mildew component, and then after washing for 16 hours at a water temperature of 50°C, an anti-bacterial and anti-mildew plastic sample is prepared. Antibacterial and antifungal tests were then carried out.

[0061]②In the injection molding process of polypropylene (PP) products, adding antifungal agents can make the final polypropyl...

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PUM

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Abstract

The invention discloses a mildew preventive which takes tebuconazole and 4, 5-dicholo-2-n-octyl-3-isothiazolinone as active components. The invention further discloses an application of the mildew preventive. As tebuconazole is relatively low in price while 4, 5-dicholo-2-n-octyl-3-isothiazolinone is relatively high in price, the tebuconazole and 4, 5-dicholo-2-n-octyl-3-isothiazolinone are compounded to obtain the mildew preventive, so that the cost is lowered while the mildew preventing effect is ensured. After the tebuconazole and 4, 5-dicholo-2-n-octyl-3-isothiazolinone are compounded, the antibacterial spectrum of the mildew preventive is expanded. The tebuconazole and 4, 5-dicholo-2-n-octyl-3-isothiazolinone are compounded, so that the mildew preventive has an obvious synergetic effect on the antibacterial effect of a lot of mildews.

Description

technical field [0001] The invention belongs to the field of functional fine chemicals, and in particular relates to a compound antifungal agent and its application. Background technique [0002] Tebuconazole (Tebuconazole), its molecular structure is: [0003] [0004] The pure product of tebuconazole is a white powdery solid, with a melting point of 60.3-61.0°C, a boiling point of >300°C, a vapor pressure of 0.17mPa (20°C), and a solubility in water of 73mg / L (25°C); the solubility in other solvents (g / L , 25°C): ethanol 730, propanol 770, n-octanol 400, toluene 610, n-hexane 24; pH 1 ~ 13 hydrolytically stable; stable to heat. [0005] Tebuconazole is mainly a sterol demethylation inhibitor, which destroys and prevents the biosynthesis of ergosterol, an important component of the cell membrane of pathogens, resulting in the inability of the cell membrane to form and the death of the bacteria. It has a good inhibitory effect on common Aspergillus niger, Penicillium...

Claims

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Application Information

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IPC IPC(8): A01N43/80A01P1/00A01P3/00C08L23/12C08L27/06A01N43/653
Inventor 孙宇
Owner 宁夏万厚生物科技有限公司
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