Cefquinome sulfate suspension injection and preparation method thereof

A technology for cefquinome sulfate and suspension injection, which is applied in the field of cefquinome sulfate suspension injection and its preparation, can solve the problems of unstable chemical properties, limited clinical application, short half-life, etc., and achieve cheap raw materials and wide Application prospect, effect of increasing stability

Inactive Publication Date: 2015-04-01
SHANGHAI TONGREN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug has a short half-life and requires frequent administration. Intramuscular injection is highly irritating to the body, and its chemical properti

Method used

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  • Cefquinome sulfate suspension injection and preparation method thereof
  • Cefquinome sulfate suspension injection and preparation method thereof
  • Cefquinome sulfate suspension injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh each raw material with the following mass percentage (take the total amount as 100mL as an example):

[0028]

[0029] Take ceftiofur hydrochloride and pulverize it in a pulverizer until 90% of the particles have a particle size of ≤20 μm; heat the soybean oil to 110°C, heat it for 3 hours to sterilize it, and then cool it to room temperature; add the sterilized cefotaxime sulfate, Glyceryl monostearate and vitamin E are stirred evenly to completely disperse them into a suspension; the resulting suspension is ultrafine through a ball mill to obtain the cefquinome sulfate suspension injection.

Embodiment 2

[0031] Weigh each raw material with the following mass percentage (take the total amount as 100mL as an example):

[0032]

[0033] Take ceftiofur hydrochloride and pulverize it in a pulverizer until 90% of the particles have a particle size of ≤20 μm; heat ethyl oleate to 120°C, keep it warm for 2 hours to sterilize, and then cool to room temperature; add the sterilized cefotaxime sulfate in the prescribed amount Stir the oxime, Span 80 and vitamin E evenly to make it completely dispersed into a suspension; ultrafine the obtained suspension through a ball mill to obtain the cefquinome sulfate suspension injection.

Embodiment 3

[0035] Weigh each raw material with the following mass percentage (take the total amount as 100mL as an example):

[0036]

[0037] Take ceftiofur hydrochloride and pulverize it in a pulverizer until 90% of the particles have a particle size of ≤20 μm; heat the MCT to 130° C., keep it warm for 1 hour to sterilize, and then cool to room temperature; add the sterilized cefotaxime sulfate and Disc 83 and vitamin E are stirred evenly to completely disperse them into a suspension; the obtained suspension is ultrafine through a ball mill to obtain the cefquinome sulfate suspension injection.

[0038] Observe the outward appearance of above embodiment gained cefquinome sulfate suspension injection, and carry out the mensuration of moisture and content, the result is as shown in table 1.

[0039] Table 1

[0040] Example

character

Moisture (%)

Content (%)

1

light brown suspension liquid

0.13

100.3

2

light brown suspension liquid ...

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PUM

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Abstract

The invention relates to a cefquinome sulfate suspension injection. The cefquinome sulfate suspension injection is characterized by comprising the following components in mass-volume ratio: 2.5% of cefquinome sulfate, 1%-3% of a suspending agent, 0.1%-0.3% of an antioxidant, and balance of a solvent for injection, totaling 100%. The invention also provides a preparation method of the cefquinome sulfate suspension injection. Since a surfactant is used as the suspending agent, the stability of the suspension can be improved; the stability of the medicine is increased; the irritation of the medicine is reduced; and the cefquinome sulfate suspension injection is simple in preparation process, is prepared from cheap and easily available raw materials, and is suitable for industrial production, so that the cefquinome sulfate suspension injection has a wide application prospect.

Description

technical field [0001] The invention relates to the field of veterinary drugs, in particular to cephalosporin veterinary drugs, in particular to a cefquinome sulfate suspension injection and a preparation method thereof. Background technique [0002] Cefquinome (Cefquinome), also known as cefquinol, cefquinome, trade name Cobactan (Cobactan), is the fourth generation animal-specific drug developed by Hoechst AG in the 1980s. Cephalosporin antibiotics. Because of the low absorption rate of cefquinome in the digestive tract, it is usually made into the form of sulfate in clinical practice. Cefquinome has a wide range of antibacterial and strong bactericidal effects on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteriaceae (E. It has a strong killing effect on many methicillin-resistant staphylococci and enterobacteriaceae. At home and abroad, it has been widely used in the clinical treatment of respiratory infections in pigs and cattle and mastitis...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61P31/04A61K47/26A61K47/14
Inventor 曹建东方玮秦佳琪
Owner SHANGHAI TONGREN PHARM CO LTD
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