Chitosan hemostatic material formed through covalent crosslinking and preparation method thereof

Abstract

The invention discloses a chitosan hemostatic material formed through covalent crosslinking and a preparation method thereof. The chitosan hemostatic material formed through covalent crosslinking is obtained by chemically crosslinking chitosan by utilizing a crosslinking agent via covalent bonds, wherein the crosslinking agent is polyethylene glycol diglycidyl ether. The preparation method of the chitosan hemostatic material formed through covalent crosslinking comprises the following steps: 1) preparing chitosan into a water solution; 2) adding the crosslinking agent to the chitosan water solution, fully stirring and mixing the materials, then pouring the mixture into a mold, and freeze-drying the product, thus obtaining the chitosan hemostatic material, wherein the crosslinking agent is polyethylene glycol diglycidyl ether. The chitosan hemostatic material and the preparation method have the beneficial effects that chitosan is crosslinked by polyethylene glycol diglycidyl ether under acidic conditions; an ethylene oxide group in polyethylene glycol diglycidyl ether carries out ring-opening reaction with hydroxyl on chitosan under acidic conditions to form the crosslinked product by generating ether bonds; the crosslinking agent used in the method is relatively safe; the preparation process is simple and practicable and is lower in production cost.

Description

technical field

[0001] The invention relates to a chitosan hemostatic material formed by covalent crosslinking and a preparation method thereof. Background technique

[0002] Bleeding in the human body can occur in various situations, such as surgery, arterial puncture (arterial interventional diagnosis and interventional treatment), war injuries, and trauma in daily life. A large amount of blood loss in the human body can lead to serious consequences, even life-threatening. Uncontrolled blood loss from trauma is the second leading cause of civilian death in everyday life and the leading cause of death on the battlefield. Therefore, the research and development of hemostatic materials has always been the focus of attention at home and abroad.

[0003] So far, in the treatment of surgical bleeding, the hemostatic materials used clinically are mainly degradable natural polymer derived materials, such as gelatin sponge, oxidized cellulose, microfibril collagen powder, fibrin ...

Images