Chitosan hemostatic material formed through covalent crosslinking and preparation method thereof
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A technology of covalent cross-linking and hemostatic materials, which is applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems such as the inability to fully meet the clinical needs, and achieves low production cost, safe cross-linking agent, and simple and easy preparation process. Effect
Active Publication Date: 2015-04-01
LANZHOU KAIBO PHARMA
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[0007] In summary, judging from the currently disclosed chitosan hemostatic material p
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[0033] The preparation method of the chitosan hemostatic material formed by covalent crosslinking, the steps are as follows:
[0034] 1) Chitosan is made into an aqueous solution;
[0035] 2) Add the cross-linking agent into the chitosan aqueous solution, stir and mix thoroughly, then pour into the mold and freeze-dry;
[0036] The cross-linking agent is polyethylene glycol diglycidyl ether.
[0037] The chemical formula of described polyethylene glycol diglycidyl ether is:
[0038] .
[0039] Preferably, n=1-20, more preferably, n=1 or 10 or 20.
[0040] The molar ratio of polyethylene glycol diglycidyl ether to monosaccharide units in chitosan molecules is 0.001:1-1:1; preferably, it is 0.05:1 or 0.10:1 or 0.20:1. The determination of the molar amount of monosaccharide units in a chitosan molecule is common knowledge.
[0041] The chitosan solution is an aqueous solution of chitosan formulated with an aqueous solution, an aqueous solution containing an organic solvent...
Embodiment 1
[0048] Weigh chitosan (viscosity 100mPa s, degree of deacetylation 90%) (0.34g, molar weight of monosaccharide unit is 21.2mmol) dissolved in 2% acetic acid solution (v / v, 17ml) to obtain 2% chitosan Sugar solution (w / v), shaking at 40°C for 24 hours to dissolve completely. Add polyethylene glycol diglycidyl ether (n = 1) (18.4mg, 0.05eq), mechanically stir and mix well, pour into a mold with a diameter of 6cm and let it stand for 12h, freeze-dry to obtain a sponge-like product with a thickness of 5mm .
Embodiment 2
[0050] The procedure is exactly the same as in Example 1, except that the amount of polyethylene glycol diglycidyl ether (n=1) added is 36.8mg (0.10eq).
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Abstract
The invention discloses a chitosan hemostatic material formed through covalent crosslinking and a preparation method thereof. The chitosan hemostatic material formed through covalent crosslinking is obtained by chemically crosslinking chitosan by utilizing a crosslinking agent via covalent bonds, wherein the crosslinking agent is polyethylene glycol diglycidyl ether. The preparation method of the chitosan hemostatic material formed through covalent crosslinking comprises the following steps: 1) preparing chitosan into a water solution; 2) adding the crosslinking agent to the chitosan water solution, fully stirring and mixing the materials, then pouring the mixture into a mold, and freeze-drying the product, thus obtaining the chitosan hemostatic material, wherein the crosslinking agent is polyethylene glycol diglycidyl ether. The chitosan hemostatic material and the preparation method have the beneficial effects that chitosan is crosslinked by polyethylene glycol diglycidyl ether under acidic conditions; an ethylene oxide group in polyethylene glycol diglycidyl ether carries out ring-opening reaction with hydroxyl on chitosan under acidic conditions to form the crosslinked product by generating ether bonds; the crosslinking agent used in the method is relatively safe; the preparation process is simple and practicable and is lower in production cost.
Description
technical field [0001] The invention relates to a chitosan hemostatic material formed by covalent crosslinking and a preparation method thereof. Background technique [0002] Bleeding in the human body can occur in various situations, such as surgery, arterial puncture (arterial interventional diagnosis and interventional treatment), war injuries, and trauma in daily life. A large amount of blood loss in the human body can lead to serious consequences, even life-threatening. Uncontrolled blood loss from trauma is the second leading cause of civilian death in everyday life and the leading cause of death on the battlefield. Therefore, the research and development of hemostatic materials has always been the focus of attention at home and abroad. [0003] So far, in the treatment of surgical bleeding, the hemostatic materials used clinically are mainly degradable natural polymer derived materials, such as gelatin sponge, oxidized cellulose, microfibril collagen powder, fibrin ...
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