Flake hydrogel material and preparation method thereof

A hydrogel, sheet-like technology, applied in the field of chemistry, can solve the problems of inconvenient movement, inability to prepare, and high energy consumption, achieve high biocompatibility and safety, avoid uneven thickness of sheets, and avoid material liquid. flowing effect

Active Publication Date: 2015-04-01
长春吉原生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Due to the low viscosity and high fluidity of the material liquid, it is not easy to move after the mold is injected with the material liquid;
[0006] 2. Due to the movement and inclination of the mold, the injection molding-radiation process cannot prepare thinner sheets;
[0007] 3. The synthesis time of the freeze-thaw process is long, and the energy consumption is high, resulting in an increase in cost;
[0008] 4. The freeze-thaw process will reduce the transparency of the hydrogel material

Method used

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  • Flake hydrogel material and preparation method thereof
  • Flake hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] According to the components in Table 1, put the raw materials into the reaction equipment with stirring and heating functions, according to the process parameters given in Attached Table 2, raise the temperature of the reaction equipment to 95°C and stir until the feed liquid is a transparent and viscous solution. Transfer the feed liquid to the storage tank and place it. After the temperature of the feed liquid drops to 20°C, pass the feed liquid through the coating equipment and coat the feed liquid between the two release films with a coating thickness of 3mm. The obtained sheet was put into a refrigeration device for refrigeration, the refrigeration temperature was 0°C, and the refrigeration time was 8 hours. The sheet was preformed, and the preformed sheet was irradiated by an electron accelerator. The radiation dose was 20kGy each time. The number of irradiations was 3 times, and the radiation-formed sheet was cut and packed into a package for radiation sterilizati...

Embodiment 2-10

[0039] According to the method described in Example 1, the hydrogel sheet was prepared according to the feed liquid formula given in Attached Table 1 and the synthesis process parameters given in Attached Table 2, respectively, to obtain the hydrogel sheet.

[0040] The sheet-shaped hydrogel materials prepared as described in Examples 1-10 all have the following performance characteristics: the water content reaches 65%-90%, the visible light transmittance is more than 80%, the cytotoxicity is less than or equal to 2 levels, and there is no skin irritation. No skin sensitization, sheet thickness difference ≤ 0.05mm, can be applied to the production of wound care dressings and beauty care products.

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Abstract

The invention relates to a flake hydrogel material and a preparation method thereof. The flake hydrogel material is prepared from the following raw materials in percentage by total weight: 4-18 percent of polyvinyl alcohol, 0-12 percent of polyvinylpyrrolidone, 0-2 percent of polyoxyethylene, 0-3 percent of sodium alginate, 0-0.5 percent of chitosan, 0-1.5 percent of xanthan gum, 0-1.5 percent of sodium polyacrylate and 69.99-93.5 percent of water. The preparation method of the flake hydrogel material comprises the following steps: heating the raw materials, stirring the mixture to obtain a transparent sticky solution; taking out the solution, cooling, and applying the solution between two release films; refrigerating at low temperature for pre-molding; radiating by virtue of an electron accelerator for molding, cutting and filling in packages; radiating to sterilize to obtain the flake hydrogel material. The flake hydrogel material prepared by the method has high water content, biocompatibility and safety, and the thickness uniformity of the flake hydrogel material is greatly improved compared with the prior art. The preparation method is simple and feasible, has high production efficiency and low production energy consumption, and can be applied to large-scale production of hydrogel flakes.

Description

technical field [0001] The invention relates to a sheet-like hydrogel material and a preparation method thereof, belonging to the field of chemistry. Background technique [0002] Hydrogel is a polymer compound with a three-dimensional network structure that can swell, absorb and release water in large quantities while maintaining its original structure. It is widely used in agriculture because of its good water retention performance and adjustable mechanical properties. , industry, construction, medical care industry and other fields. Hydrogel materials can be synthesized by physical and chemical methods. The hydrogel synthesized by physical synthesis method has a spatial grid structure formed by intermolecular forces or entanglement of molecular chains, and has poor shape and performance stability under high temperature or other special conditions, which limits its application field. Chemically synthesized hydrogel materials are obtained by adding initiators, cross-linki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/24A61L15/26A61L15/28A61K8/86A61Q19/00
Inventor 王靖哲荆晶余航于春暖王栗陈亮
Owner 长春吉原生物科技有限公司
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