Salidroside enteric-coated tablet and preparation method thereof

A technology of salidroside intestines and salidroside, which is applied in the direction of medical formulas, medical preparations containing no active ingredients, and medical preparations containing active ingredients, etc. Solve the problems of poor absorption of tianoside, etc., to achieve the effect of increasing bioavailability, improving drug absorption, and easy operation

Active Publication Date: 2017-06-20
WUHAN SYNCHALLENGE UNIPHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a salidroside enteric-coated tablet to improve the instability of salidroside in gastric juice when taken orally, and at the same time improve the problem of poor absorption of salidroside in the intestinal tract

Method used

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  • Salidroside enteric-coated tablet and preparation method thereof
  • Salidroside enteric-coated tablet and preparation method thereof
  • Salidroside enteric-coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Salidroside enteric-coated tablets are made from the following components:

[0038] Proportion of original adjuvant (parts by weight)

[0039] 20 parts of salidroside

[0040] Hypromellose phthalate 8 parts

[0041] Cellulose acetate phthalate 2 parts

[0042] Microcrystalline cellulose 10 parts

[0043] 10% povidone K30 ethanol solution 10 parts

[0044] 20 parts of crospovidone

[0045] Magnesium stearate 5 parts

[0046] TPGS1000 5 copies

[0047] Sodium carbonate 2 parts

[0048] The preparation method is as follows:

[0049] (1) Weigh half the amount of cross-linked povidone, microcrystalline cellulose, TPGS1000, sodium carbonate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0050] (2) Weigh the other half of the formula, crospovidone and magnesium stearate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0051] (3) Weigh the formula amount of salidroside through an 80-mesh sieve for use;

[0052] (4) Add the salidroside obtained in step (3) an...

Embodiment 2

[0057] Salidroside enteric-coated tablets are made from the following components:

[0058] Proportion of original adjuvant (parts by weight)

[0059] 40 parts of salidroside

[0060] Hypromellose phthalate 10 parts

[0061] 10 servings of lactose

[0062] Hydroxypropyl cellulose 10 parts

[0063] Sodium Carboxymethyl Starch 10 parts

[0064] Magnesium stearate 5 parts

[0065] TPGS1000 5 copies

[0066] Sodium carbonate 1 part

[0067] The preparation method is as follows:

[0068] (1) Weigh half of the formula amount of sodium carboxymethyl starch, lactose, TPGS1000, sodium carbonate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0069] (2) Weigh the other half of the formula amount, pulverize and mix the sodium carboxymethyl starch and magnesium stearate, pass through an 80-mesh sieve, and set aside;

[0070] (3) Weigh the formula amount of salidroside through an 80-mesh sieve for use;

[0071] (4) Add the salidroside obtained in step (3) and the mixture obtained in step (...

Embodiment 3

[0076] Salidroside enteric-coated tablets are made from the following components:

[0077] Proportion of original adjuvant (parts by weight)

[0078] 10 parts of salidroside

[0079] Cellulose acetate phthalate 10 parts

[0080] 20 parts of microcrystalline cellulose

[0081] Hypromellose 10 parts

[0082] Cross-linked povidone 10 parts

[0083] 5 servings of talcum powder

[0084] TPGS400 5 copies

[0085] Sodium bicarbonate 3 parts

[0086] The preparation method is as follows:

[0087] (1) Weigh half the amount of cross-linked povidone, microcrystalline cellulose, TPGS400, sodium bicarbonate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0088] (2) Weigh the other half of the formula, crospovidone and talcum powder, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0089] (3) Weigh the formula amount of salidroside through an 80-mesh sieve for use;

[0090] (4) Add the salidroside obtained in step (3) and the mixture obtained in step (1) to a wet granulat...

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PUM

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Abstract

The invention discloses a salidroside enteric-coated tablet and a preparation method thereof. The tablet comprises a salidroside tablet core and an enteric-coated layer. The salidroside tablet core is composed of salidroside main drug and auxiliary materials. The auxiliary materials include: diluents, disintegrating agents, binders, lubricants, intestinal absorption promoting agents and pH regulators, etc. Enteric coatings include: hydroxypropylmethylcellulose phthalate or cellulose acetate phthalate, etc. The invention solves the problem of salidroside being unstable in gastric juice and at the same time solves the problem of insufficient absorption of salidroside in intestinal tract.

Description

Technical field [0001] The invention relates to a salidroside enteric-coated tablet and a preparation method thereof. Background technique [0002] Rhodiola is a precious medicinal material of Chinese medicine and Tibetan medicine. Salidroside is the active ingredient in Rhodiola. At present, salidroside can be obtained by chemical synthesis or extraction from plants. Pharmacological studies have shown that salidroside has good cardiovascular and cerebrovascular effects, such as improving vascular effects, protecting myocardial ischemia, improving heart function, and anti-arrhythmia. [0003] In addition, patent research shows that salidroside has new effects in preventing and treating muscle atrophy, stroke, anti-asthma, anti-depression and so on. Patent CN102727505A discloses that salidroside can inhibit the expression of muscle atrophy-specific factor Atrogin-1, myotube atrophy and the reduction of the cross-sectional area of ​​skeletal muscle fibers in the process of muscle ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/7032A61K47/38A61K47/02A61P9/00A61P9/10A61P9/06
Inventor 巨修练王均震郑文钺汤兴国袁振昌
Owner WUHAN SYNCHALLENGE UNIPHARM INC
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