Preparation method for glycerol tributyrate microcapsule

A technology of tributyrin and tributyrin, applied in the field of preparation of tributyrin microcapsules, can solve the problems of easy agglomeration, wet adsorbent surface, inconvenient use and the like, and achieves low production cost, Good compatibility and easy to use effect

Active Publication Date: 2015-04-15
曹胜炎 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although tributyrin can play the above two functions at the same time, it is inconvenient to use because tributyrin is liquid
Chinese patent application (Application No. 201410298903.2) "Trigeryl tributyrate solid granular preparation and its preparation method and application" discloses a method for preparing solid preparations by using white carbon black silica gel to adsorb tributyrin, but using inorganic adsorption There are many defects in the simple adsorption of tributyrin by the inorganic adsorbent: when the inorganic adsorbent adsorbs more tributyrin, the surface of the adsorbent is relatively wet, easy to agglomerate, and has no fluidity; at the same time, due to the high boiling point of tributyrin, it cannot Dried granules are produced using conventional methods such as heat drying, thereby affecting the commercial form of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Add 100kg of stearic acid, 55kg of tributyrin, and 5kg of tripolyglycerin fatty acid ester into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0022] 2. Add 1000kg of hot water at 80±5°C to the 2000L reactor, inject the melted oil phase in step 1, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0023] 3. Weigh 13kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, and filter the water with a 200-mesh filter. The filter cake was dried in a drying room at 50°C for 20-40 hours to obtain 173 kg of tributyrin fatty acid calcium microcapsules, of which the content of tributyrin was 31.8%.

Embodiment 2

[0025] 1. Add 100kg of palmitic acid, 100kg of tributyrin, 2kg of tripolyglycerin fatty acid ester, 2kg of Tween 80 into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0026] 2. Add 1300 kg of 80±5°C hot water into the 2000L reactor, inject the melted oil phase in the first step, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0027] 3. Weigh 15kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, filter the water with a 200-mesh filter, and filter Dry the cake in a drying room at 50°C for 20-40 hours to obtain 220 kg of tributyrin fatty acid calcium microcapsules with a tributyrin content of 45.5%.

Embodiment 3

[0029] 1. Add 100kg of palmitic acid, 70kg of tributyrin, and 5kg of tripolyglycerin fatty acid ester into a 500L reactor, heat and melt to stabilize the material temperature at 80±5°C;

[0030] 2. Add 1000kg of 80±5℃ hot water into the 2000L reactor, pour the melted oil phase in step 1, and stir for 3~10min to make the oil phase evenly dispersed in the water;

[0031] 3. Weigh 15kg of calcium hydroxide and 100kg of water to form milk of lime, pump it in from the lower part of the reaction kettle and stir, continue to stir for 10 minutes after adding the milk of lime, discharge the material, filter the water with a 200-mesh filter, and filter The cake was dried in a drying room at 50°C for 20-40 hours to obtain 190 kg of tributyrin fatty acid calcium microcapsules with a tributyrin content of 36.8%.

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Abstract

The invention discloses a preparation method for a glycerol tributyrate microcapsule. The glycerol tributyrate microcapsule is prepared from the following raw materials: 100 parts of fatty acid, 50-100 parts of glycerol tributyrate, 1-10 parts of an emulsifier and 13-15 parts of calcium hydroxide. The preparation method comprises the following steps: mixing glycerol tributyrate, fatty acid and the emulsifier, heating, melting, and uniformly stirring in warm water with the temperature of 80+/-5 DEG C to form emulsion; dissolving calcium hydroxide in water to prepare 10-20% of lime emulsion; mixing and stirring the emulsions obtained in the previous two steps and reacting to generate solid particles; filtering out the moisture and drying a filter cake to form the finished glycerol tributyrate microcapsule which freely flows at the room temperature. The preparation method has the advantages of low production cost, simple process, cheap equipment and favorability for industrialized production; the obtained finished solid particle product with the flowing property is relatively convenient when being used as an animal feed additive.

Description

Technical field [0001] The invention involves animal feed additives, especially the preparation method of a tria -butyl glycerin microcope. Background technique [0002] T -ntenic acid is of great significance to the intestinal nutrition of animals. ① It is not only the main source of the energy of animal colon cells, but also the substrate of the synthesis of lipids of cell membranes.Poetry has an important role in apoptosis.② Tannic acid can reduce the pH value of the intestinal environment and inhibit the growth of harmful bacteria. Therefore, in the feed industry, buty acid and its salt are widely used as a multi -functional feed additive.However, because butyl acid is liquid at room temperature and has a very difficult smell, it is very inconvenient to use. Therefore, it is generally necessary to make it into use of butyl -l -l -t -itlatium or calcium butadium. [0003] Tannic acid is an organic compound of small molecules. It will be absorbed quickly in the front of the sto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23P1/04
Inventor 曹胜炎王宏雁
Owner 曹胜炎
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