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Antibacterial false tooth soft lining material and application thereof

A bacteriostatic and denture technology, applied in dental preparations, dental prostheses, compression molding cups, etc., can solve the problems of high cytotoxicity, concentration dependence, and easy drug resistance, and achieve good biocompatibility and strong The effect of inhibition

Active Publication Date: 2015-04-29
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial ability of organic antibacterial agents mainly comes from organic substances such as quaternary ammonium salts, bismuths, and alcohols. Large, easy to produce drug resistance, cause bacterial imbalance, concentration dependence, short drug half-life to effective cycle, etc., which limit its application in the modification of soft lining materials

Method used

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  • Antibacterial false tooth soft lining material and application thereof
  • Antibacterial false tooth soft lining material and application thereof
  • Antibacterial false tooth soft lining material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Formulation and preparation method

[0042] formula:

[0043]

[0044] Wherein, the rubber matrix is ​​composed of eucommia gum and butadiene rubber, and the mass ratio of eucommia gum and butadiene rubber is: 10-90:90-10.

[0045] Preparation:

[0046] According to the proportion by weight, Eucommia ulmoides gum, butadiene rubber, vulcanization activator, magnesium oxide, stearic acid, and sulfur-containing accelerator were added in sequence, mixed evenly at 70°C-80°C, and then cooled, and waited for After cooling to room temperature, add sublimated sulfur and mix well; then stand for 22-26 hours, vulcanize at 140°C-160°C for 20-40 minutes to form, the vulcanization pressure is 9.5MPa-10.5MPa, and the material is released after curing.

[0047] 2. Materials and methods

[0048] 2.1 Main materials

[0049]

[0050] 2.2 Main equipment

[0051]

[0052]

[0053] 2.3 Extraction of eucommia gum

[0054] Using the petroleum ether-ethanol method, first cr...

Embodiment 2

[0167] Embodiment 2 bacteriostasis test

[0168] 1. English abbreviation

[0169]

[0170] 2.1 Experimental materials

[0171] 2.1.1 Standard strains

[0172] Candida albicans CMCC (F) 98001, provided by China Microorganism Collection Management Center.

[0173] 2.1.2 Main experimental equipment and instruments

[0174]

[0175]

[0176] Water sandpaper of various particle sizes, glass test tube, sterilized tweezers, 250ml Erlenmeyer flask, inoculation loop, alcohol lamp

[0177] 2.1.3 Main experimental materials

[0178] 2.1.3.1 Eucommia gum composite material

[0179] The eucommia gum and butadiene rubber were softened several times on the double-roll mill at about 65°C according to the formula in the following table (Table 2-1), and then added sublimated sulfur, zinc oxide, magnesium oxide, stearic acid, Sulfur-containing accelerator CZ, anti-aging agent, fumed white carbon black, knead for a period of time, after the kneading is even, thin pass several times...

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Abstract

The invention discloses an antibacterial false tooth soft lining material which is prepared from gutta-percha in a compounded manner. The antibacterial false tooth soft lining material can be also named as an gutta-percha composite false tooth soft lining material, and is prepared from a rubber matrix, a vulcanizing activator, magnesium oxide, stearic acid, sublimed sulfur, a sulfur-containing accelerant and an anti-aging agent, wherein the rubber matrix consists of gutta-percha and cis-polybutadiene; the gutta-percha accounts for 90% of the rubber matrix in mass percentage. The antibacterial false tooth soft lining material has certain antibacterial property, and particularly has a relatively high inhibition function on candida albicans.

Description

technical field [0001] The invention belongs to the technical field of denture soft lining materials, and in particular relates to denture soft lining materials with antibacterial properties and applications thereof. Background technique [0002] Denture soft lining materials, also known as elastic denture liner materials, can use its elastic deformation to buffer the occlusal force, tighten the contact relationship between the denture tissue surface and the alveolar mucosa, and use the undercut area of ​​the tissue to improve the retention of the denture It is one of the important measures commonly used clinically to relieve symptoms such as poor retention, repeated tenderness, and low chewing efficiency during the wearing of removable dentures. As a material that can be used for a long time and is in contact with the surface of the oral mucosa, its performance stability and easy-to-cause oral mucosal diseases are the main factors that limit its application. Among them, de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/00C08L7/00C08L9/00C08K13/02C08K3/22C08K5/09C08K3/06C08K5/47
Inventor 冯云枝赵荣罗恒苏宁波龙慧孔祥宇朱骏飞向大雄
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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