Preparation method for porous beta-TCP ceramic/gelatin composite material

A composite material and gelatin technology, used in medical science, prosthesis, etc., can solve the problems of inability to repair load-bearing bone defects, limited application scope, insufficient mechanical strength, etc., and achieve high compressive strength, wide application prospects, and pore connectivity. good effect

Inactive Publication Date: 2015-05-13
邹仕放
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Problems solved by technology

[0002] β-Tricalcium Phosphate (β-TCP) is a kind of biodegradable material that has been widely studied in bone tissue engineering. Therefore, its scope of application in clinical treatment is limited; gelatin contains amino acids required by the human body, and is used in clinical research as a good polymer biomaterial, showing good hemocompatibility and tissue compatibility
At present, there are many kinds of reinforcement materials for stents, but it is rare to use K 2 HP0 4 Increased stent strength reported

Method used

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specific Embodiment

[0009] Specific embodiments: the preparation process of the present invention includes the preparation of 1.β-TCP powder: calcium oxide is made into calcium hydroxide suspension, and under ultrasonic conditions, it is slowly added dropwise in the stirred phosphoric acid solution, and the Ca of reaction / P is 1.5, the precursor is obtained by suction filtration after the reaction, dried, and calcined at 1100°C to obtain β-TCP powder; 2. Preparation of porous β-TCP scaffold: including β-TCP powder pretreatment, porogen treatment, and molding treatment Step, β-TCP powder pretreatment, β-TCP powder with K 2 HP0 4 Solution mixing, drying, grinding, porogen treatment, using liquid hydrocarbons as the binder and mixing with the porogen (the porogen is 847-508μm and 246-198μm spherical stearyl carboxyl) to obtain binder wrapping The porogen is mixed evenly with the processed β-TCP powder, and adjusted into a fluid slurry, which is used for pressure molding and molding treatment. The ...

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PUM

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Abstract

A preparation method for a porous beta-TCP ceramic / gelatin composite material belongs to the field of preparation of artificial bone scaffold materials. Concretely, the preparation method is used to prepare the porous beta-TCP ceramic / gelatin composite material of which the structure and the composition are similar to those of natural bone. According to the preparation method, a foaming process is employed for preparing porous beta-TCP, a high-temperature adhesive K2HPO4 is added for improving the scaffold strength, and a porous beta-TCP support is combined with gelatin for improving the strength and the toughness of the porous support, and thus the porous beta-TCP ceramic / gelatin composite material of which the structure and the composition are similar to those of natural bone is prepared. The porous beta-TCP ceramic / gelatin composite material prepared by the preparation method has the advantages of good pore connectivity, high porosity, high water absorption rate, high compressive strength and the like, the composition and the structure of the composite scaffold are similar to those of natural bone, and the composite scaffold has wide application prospect.

Description

technical field [0001] The invention belongs to the field of artificial bone scaffold material preparation. Background technique [0002] β-Tricalcium Phosphate (β-TCP) is a kind of biodegradable material that has been widely studied in bone tissue engineering. Therefore, its application range in clinical treatment is limited; gelatin contains amino acids required by the human body, and is used in clinical research as a good polymer biomaterial, showing good hemocompatibility and tissue compatibility . At present, there are many kinds of reinforcement materials for stents, but it is rare to use K 2 HP0 4 Increased scaffold strength reported. Contents of the invention [0003] The purpose of the present invention is to provide a method for preparing porous β-TCP ceramic / gelatin composite material with structure and composition similar to natural bone. [0004] The present invention is realized through the following technical solutions: a preparation method of porous β-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/22A61L27/12A61L27/56C04B35/447C04B35/622
Inventor 邹仕放
Owner 邹仕放
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