A kind of nano-microsphere formed based on host-guest interaction and its preparation method and application
A nano-microsphere, host-guest technology, which is applied in the direction of non-active ingredients of polymer compounds, anti-tumor drugs, block delivery, etc., can solve the problem of low solubility, achieve good biocompatibility, good drug sustained release function, The effect of structural stability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0024] Example 1: Using amantadine as an initiator to initiate the polymerization of ε-caprolactone
[0025] Under the protection of argon, 30 mg amantadine, 2.2 mL ε-caprolactone, and 10 uL stannous octoate were added into a 25 mL round bottom flask, and the mixture was stirred and reacted at 120° C. for 48 hours. After the reaction, cool to room temperature, add 10 mL of dichloromethane to dissolve the reaction product, and then precipitate in 200 mL of anhydrous ether to obtain a white solid product, dry it in vacuum, and obtain the product amantadine as the initiator to initiate the polymerization of ε-caprolactone, labeled For: ada-PCL. The molecular weight was determined to be 9803 g / mol by size exclusion chromatography. 1 HNMR (400MHz, CDCl 3 ,δ): 1.41(m,2H), 1.67(m,4H), 1.99(s,adamantyl), 2.07(s,adamantyl), 2.32(t,2H), 4.08(t,2H).
Embodiment 2
[0026] Example 2: Using amantadine as an initiator to initiate the polymerization of ε-caprolactone
[0027] Under argon protection, 30 mg amantadine, 1 mL ε-caprolactone, and 10 uL stannous octoate were added into a 25 mL round bottom flask, and the mixture was stirred and reacted at 120° C. for 48 hours. After the reaction, cool to room temperature, add 10 mL of dichloromethane to dissolve the reaction product, and then precipitate in 200 mL of anhydrous ether to obtain a white solid product, dry it in vacuum, and obtain the product amantadine as the initiator to initiate the polymerization of ε-caprolactone, labeled For: ada-PCL. The molecular weight was determined to be 3945 g / mol by size exclusion chromatography.1 H NMR (400MHz, CDCl 3 ,δ): 1.41(m,2H), 1.67(m,4H), 1.99(s,adamantyl), 2.07(s,adamantyl), 2.32(t,2H), 4.08(t,2H).
Embodiment 3
[0028] Example 3: Using amantadine as an initiator to initiate the polymerization of D, L-lactide
[0029] Add 15mL of anhydrous toluene, 30mg of amantadine, and 2g of D,L-lactide into a 50mL round-bottomed flask under the protection of argon, then add 10uL of stannous octoate, and stir at 120°C for 48 hours. Add 10mL of dichloromethane to dilute the solution, then precipitate the product in 300mL of methanol, and then dissolve the white solid in 10mL of acetone, precipitate it in 200mL of water to obtain a white solid, and dry the resulting solid in vacuum to obtain amantadine as an initiator to initiate polymerization D. L-lactide, labeled: ada-PDLLA. The molecular weight was determined to be 9764 g / mol by size exclusion chromatography. 1 H NMR (400MHz, CDCl 3 ,δ): 1.58 (m, 3H), 1.99 (s, adamantyl), 2.07 (s, adamantyl), 5.21 (m, 1H).
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle size | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More