Hydrogel and preparation method thereof

A hydrogel and modification technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of sudden release effect and affect the efficacy of drugs in hydrogels and other problems, to achieve good effect, good degradability and biocompatibility, and improve the effect of treatment.

Active Publication Date: 2015-05-27
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the swelling characteristics of the current injectable hydrogel and the internal porous structure, the hydrogel will have a burst release effect, which affects the efficacy of the drug in the hydrogel.

Method used

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  • Hydrogel and preparation method thereof
  • Hydrogel and preparation method thereof
  • Hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0173] The invention provides a method for preparing a hydrogel, comprising:

[0174] mixing drug-loaded particles, modified chitosan, poly-γ-glutamic acid star-shaped block copolymer, poly-L-lysine star-shaped block copolymer and solvent to obtain hydrogel; The drug granules are prepared from modified dextran and drugs, and the modified dextran has the structure shown in formula I:

[0175]

[0176] In formula I, z is 50-600; R is -H or a group with the structure shown in formula 1:

[0177]

[0178] Described modified chitosan has the structure shown in formula II:

[0179]

[0180] In formula II, 400≤(m+n)≤600; R 1 is -H or a group with the structure shown in formula 2:

[0181]

[0182] In formula 2, 200≤h≤300;

[0183] The poly-γ-glutamic acid star block copolymer comprises a block of structure shown in formula III and a block of structure shown in formula IV:

[0184]

[0185] In formula III, 40≤r≤230;

[0186] In formula IV, 40≤k≤140;

[0187] Desc...

Embodiment 1

[0207] The dextran of 2g and the sodium periodate of 0.66g are dissolved in pure water, carry out the reaction of 18 hours under room temperature, lucifuge, the condition of stirring, the reaction product obtained is successively settled with acetone, separates the sedimentation product; The sedimentation product is dissolved in the water phase for dialysis, and the obtained dialysis product is freeze-dried to obtain the modified dextran.

[0208] The modified dextran prepared in Example 1 of the present invention was detected by nuclear magnetic resonance, and the detection results were as follows: figure 1 as shown,figure 1 The H NMR spectrum of the modified dextran prepared in Example 1 of the present invention is obtained by figure 1 It can be seen that the modified dextran prepared in Example 1 of the present invention has a structure shown in formula 4:

[0209]

[0210] In Formula 4, z is 280-410, and R is -H.

Embodiment 2

[0212] Modified dextran was prepared according to the method described in Example 1. The difference from Example 1 was that 1.9 g of dextran was used to replace 2 g of dextran, and 1.25 g of sodium periodate was used to replace 0.66 g of sodium periodate.

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Abstract

The invention provides a hydrogel. The hydrogel is prepared from the following components: medicine-loading particles, modified chitosan with a structure shown in a formula II, a poly-gamma-glutamic acid star-type block copolymer containing blocks with structures shown in a formula III and a formula IV, a poly-L-lysine star-type block copolymer containing blocks with structures shown in a formula V and a formula VI, and a solvent, wherein the medicine-loading particles are prepared from modified glucan with a structure shown in a formula I and medicines. The hydrogel provided by the invention is a hydrogel based on electrostatic action and Schiff base bond crosslinking; by virtue of the combination of physical electrostatic action and Schiff base bond chemical crosslinking, the hydrogel provided by the invention has relatively high strength and good stability, and ensures that the requirements of clinical injection can be met; and moreover, the medicine-loading particles are taken as a chemical crosslinking agent so as to ensure that medicines in the hydrogel can be released slowly, the targeted release and enrichment of the medicines at focus locations can be achieved, and thus the treatment effects of the medicines can be improved. The invention also provides a preparation method of the hydrogel.

Description

technical field [0001] The invention relates to the technical field of targeted drug delivery, in particular to a hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a three-dimensional network polymer system with stable shape, and its interior can absorb and maintain a large amount of water, similar to the outer matrix structure of natural cells, which can fix cells and biomolecules inside, thereby constructing tissue engineering scaffolds , for the repair of defective tissues and organs. At the same time, the hydrogel can also be used as a "shell" to load drugs. After the hydrogel is loaded with drugs, it can continuously release the drugs into the body fluid at the tumor lesion in the body, which has important applications in the field of anti-tumor targeted drugs. [0003] Clinically, hydrogel can enter the body through surgical transplantation or injection. To implant the hydrogel into the body through surgery, it is necessary to pre-fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/36A61K47/34A61K9/06A61K38/20A61K38/21A61P35/00
Inventor 贺超良吴锡龙陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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