Hydrogel and preparation method thereof

A hydrogel and modification technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of sudden release effect and affect the efficacy of drugs in hydrogels and other problems, to achieve good effect, good degradability and biocompatibility, and improve the effect of treatment.
CN104645348AActive Publication Date: 2015-05-27CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2015-05-27

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Abstract

The invention provides a hydrogel. The hydrogel is prepared from the following components: medicine-loading particles, modified chitosan with a structure shown in a formula II, a poly-gamma-glutamic acid star-type block copolymer containing blocks with structures shown in a formula III and a formula IV, a poly-L-lysine star-type block copolymer containing blocks with structures shown in a formula V and a formula VI, and a solvent, wherein the medicine-loading particles are prepared from modified glucan with a structure shown in a formula I and medicines. The hydrogel provided by the invention is a hydrogel based on electrostatic action and Schiff base bond crosslinking; by virtue of the combination of physical electrostatic action and Schiff base bond chemical crosslinking, the hydrogel provided by the invention has relatively high strength and good stability, and ensures that the requirements of clinical injection can be met; and moreover, the medicine-loading particles are taken as a chemical crosslinking agent so as to ensure that medicines in the hydrogel can be released slowly, the targeted release and enrichment of the medicines at focus locations can be achieved, and thus the treatment effects of the medicines can be improved. The invention also provides a preparation method of the hydrogel.
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Description

technical field

[0001] The invention relates to the technical field of targeted drug delivery, in particular to a hydrogel and a preparation method thereof. Background technique

[0002] Hydrogel is a three-dimensional network polymer system with stable shape, and its interior can absorb and maintain a large amount of water, similar to the outer matrix structure of natural cells, which can fix cells and biomolecules inside, thereby constructing tissue engineering scaffolds , for the repair of defective tissues and organs. At the same time, the hydrogel can also be used as a "shell" to load drugs. After the hydrogel is loaded with drugs, it can continuously release the drugs into the body fluid at the tumor lesion in the body, which has important applications in the field of anti-tumor targeted drugs.

[0003] Clinically, hydrogel can enter the body through surgical transplantation or injection. To implant the hydrogel into the body through surgery, it is necessary to pre-fa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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