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Reactive antimicrobial additive and preparation method thereof

A technology of antibacterial agents and additives, which is applied in the field of antibacterial agent additives and its preparation, and can solve problems such as drug resistance, no drug resistance, and reduced antibacterial persistence

Inactive Publication Date: 2015-05-27
米尔斯(北京)文化发展股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5. No drug resistance. The discovery and use of antibiotics has made great contributions to human health, but it has also brought about a huge problem in the long course of use—drug resistance, which can now tolerate a variety of antibiotics Superbugs emerge in endlessly
[0003] In the selection of existing antibacterial agent additives, antibiotics and silver ions are mostly selected, and they are added to antibacterial materials by physical blending, which will inevitably bring about drug resistance and cumulative toxicity caused by long-term penetration of silver ions into the human body. , antibacterial agent migration reduces antibacterial persistence and other issues

Method used

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  • Reactive antimicrobial additive and preparation method thereof
  • Reactive antimicrobial additive and preparation method thereof
  • Reactive antimicrobial additive and preparation method thereof

Examples

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Embodiment 1

[0042] A kind of reactive antimicrobial agent additive, described reactive antimicrobial agent additive is modified PHMG, calculated in parts by weight, its raw material composition and content are as follows:

[0043]PHMG 2 parts

[0044] Vinyl monomer 20 parts;

[0045] The PHMG is obtained by melt polycondensation at 180° C. with guanidine hydrochloride and hexamethylenediamine in a molar ratio of 1:1;

[0046] The vinyl monomer is acrylic acid.

[0047] The preparation method of above-mentioned a kind of reactive antimicrobial agent additive, the steps are as follows:

[0048] Calculated in parts by weight, add 2 parts of PHMG and 20 parts of acrylic acid to 100 parts of dimethyl sulfoxide and stir to dissolve, then control the temperature at 55°C and the rotation speed at 200r / min for 5.5h. After the reaction, use 400 Parts of organic solvent acetone precipitated the product, and the resulting product was repeatedly washed with acetone for 3 times, and then dried at a ...

Embodiment 2

[0062] A kind of reactive antimicrobial agent additive, described reactive antimicrobial agent additive is modified PHMG, calculated in parts by weight, its raw material composition and content are as follows:

[0063] 5 servings of PHMG

[0064] Vinyl monomer 5 parts;

[0065] The PHMG is obtained by melt polycondensation at 180°C with a molar ratio of guanidine hydrochloride and butylenediamine at 1:1;

[0066] The vinyl monomer is methacrylic acid.

[0067] The preparation method of above-mentioned a kind of reactive antimicrobial agent additive, comprises the steps:

[0068] (1) Calculated in parts by weight, dissolve 5 parts of vinyl monomer in 20 parts of dimethyl sulfoxide, add 0.5 part of activator 1-hydroxybenzotriazole (HOBt) and 0.5 part of condensate The mixture N, N-diisopropylcarbodiimide (DIC) was stirred and activated at room temperature for 1 hour to obtain solution 1;

[0069] The amount of dimethyl sulfoxide used above is calculated by weight ratio, and ...

Embodiment 3

[0076] A kind of reactive antimicrobial agent additive, described reactive antimicrobial agent additive is modified PHMG, calculated in parts by weight, its raw material composition and content are as follows:

[0077] PHMG 4 parts

[0078] 8 parts of vinyl monomer;

[0079] The PHMG is obtained by melt polycondensation at 180°C with a molar ratio of guanidine hydrochloride and octyldiamine in a molar ratio of 1:1;

[0080] The vinyl monomer is a mixture of acrylic acid and methacrylic acid in mass ratio, that is, methacrylic acid:acrylic acid is 1:0.6.

[0081] The preparation method of above-mentioned a kind of reactive antimicrobial agent additive specifically comprises the steps:

[0082] (1) Calculated in parts by weight, decompose 5 parts of methacrylic acid and 3 parts of acrylic acid into 32 parts of dimethyl sulfoxide, add 1.2 parts of activator 1-hydroxybenzotriazole (HOBt) and 1.2 parts of condensing agent N, N-diisopropylcarbodiimide (DIC) were stirred and activ...

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Abstract

The invention discloses a reactive antimicrobial additive and a preparation method thereof. The reactive antimicrobial additive is modified polyhexamethylene guanidine hydrochloride and is prepared from the following raw materials in parts by weight: 2-6 parts of polyhexamethylene guanidine hydrochloride and 5-20 parts of a vinyl monomer. According to the preparation method, the vinyl monomer and polyhexamethylene guanidine hydrochloride are subjected to a direct reaction or a condensation reaction so as to obtain the product. The direction reaction comprises the following operating steps: dissolving polyhexamethylene guanidine hydrochloride and vinyl monomer in dimethyl sulfoxide, heating, directly reacting, thereby obtaining the reactive antimicrobial additive; and the condensation reaction comprises the following operating steps: dissolving the vinyl monomer in water or dimethyl sulfoxide, adding a condensing agent and an activating agent into the solution to realize activating, adding polyhexamethylene guanidine hydrochloride for reacting, thereby obtaining the reactive antimicrobial additive. The reactive antimicrobial additive has broad-spectrum high-efficiency antibacterial performance and can be fixedly arranged on a high polymer matrix used for manufacturing antibacterial materials in a chemical bond mode, so that the antimicrobial is prevented from being taken by a human body and the antibacterial effect is maintained for a long time.

Description

technical field [0001] The invention relates to an antibacterial agent additive and a preparation method thereof, in particular to an antibacterial agent additive suitable for coatings, plastics and medical polymer materials and a preparation method thereof. Background technique [0002] Antibacterial materials are of great significance to protect the healthy life of human beings. As antibacterial active ingredients in antibacterial materials, the selection of antibacterial additives has become a key factor in the production of antibacterial materials. The selection of antibacterial additives needs to comply with the following criteria: 1. With broad-spectrum antibacterial properties, there are many kinds of bacteria that damage human health, such as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Klebsiella, Enterococci, some fungi, etc., so antibacterial agents with a single type of antibacterial often fail to meet the antibacterial performance requirement...

Claims

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Application Information

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IPC IPC(8): C08F283/00C08F220/06C08L51/08A01P1/00A01P3/00
Inventor 吴蓁宋羽顾顺超张英强
Owner 米尔斯(北京)文化发展股份有限公司
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