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Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation

A technology for the upper respiratory tract and traditional Chinese medicine preparations, which is applied in the direction of medical formulas, respiratory diseases, and medical preparations containing active ingredients, etc. It can solve the problems of inappropriate use of granules, reduced drug efficacy, and large dosage, so as to reduce the consumption of excipients Quantity, simple production method, guaranteed clinical efficacy

Inactive Publication Date: 2015-06-03
GUANGXI DOUBLE ANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The granules prepared by the traditional production method are used as molding aids, which have the following disadvantages: (1) the sucrose content is high, easy to deliquescence, softening and deterioration, not suitable for long-term storage, and the stability of the drug is not good, which may easily cause the drug to enter the human body. (2) Since sucrose has strong biological activity, it can cause gastritis, obesity, diabetes and dental caries in children, so granules are not suitable for diabetes and other contraindicated drugs. Diabetic patients restrict the medication of many children, elderly and sugar-free patients; (3) The dosage is large (10-20g at a time), and the quality standards are recorded in the "Ministry of Health Drug Standards" Traditional Chinese Medicine Prescriptions Volume 10 P115 , due to the early drafting of the adopted standards, the specificity of some inspection items is poor, and it is far from meeting the current requirements for drug quality standards

Method used

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  • Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0047] (1) Take 460g of honeysuckle, add water, then add hydrochloric acid until the pH value of the solution is about 4, the ratio of the weight of water to the weight of honeysuckle is 11:1, distill, the time of distillation is 1.5 to 3 hours, collect the distillate, add 80gβ to the distillate Cyclodextrin, mixing, filtering, drying, drying temperature ≤ 50 ℃, to obtain solid powder, standby;

[0048] (2) Treat the distilled water decoction solution obtained in step (1) with microwaves, the time of microwave treatment is 20 to 40 minutes, filter, add water to the filter residue, and the ratio of the weight of water to the weight of the filter residue is 8:1. The time is 20 to 40 minutes, filter, combine the filtrates, vacuum concentrate to a clear paste with a relative density of 1.10 to 1.15 at 60°C, add ethanol, the ratio of the weight of ethanol to the weight of the concentrated solution is 3:1, stir and stand for 22 After ~26 hours, filter, and concentrate the filtrate i...

Embodiment 2

[0052] (1) Take 500g of honeysuckle, add water, then add hydrochloric acid until the pH value of the solution is about 4, the ratio of the weight of water to the weight of honeysuckle is 11:1, distill, the distillation time is 1.5 to 3 hours, collect the distillate, add 50g of β to the distillate Cyclodextrin, mixing, filtering, drying, drying temperature ≤ 50 ℃, to obtain solid powder, standby;

[0053] (2) Treat the distilled water decoction solution obtained in step (1) with microwaves, the time of microwave treatment is 20 to 40 minutes, filter, add water to the filter residue, and the ratio of the weight of water to the weight of the filter residue is 8:1. The time is 20 to 40 minutes, filter, combine the filtrates, vacuum concentrate to a clear paste with a relative density of 1.10 to 1.15 at 60°C, add ethanol, the ratio of the weight of ethanol to the weight of the concentrated solution is 3:1, stir and stand for 22 After ~26 hours, filter, and concentrate the filtrate ...

Embodiment 3

[0057] (1) Take 540g of honeysuckle, add water, then add hydrochloric acid until the pH value of the solution is about 4, the ratio of the weight of water to the weight of honeysuckle is 11:1, distill, the distillation time is 1.5 to 3 hours, collect the distillate, add 30gβ to the distillate Cyclodextrin, mixing, filtering, drying, drying temperature ≤ 50 ℃, to obtain solid powder, standby;

[0058] (2) Treat the distilled water decoction solution obtained in step (1) with microwaves, the time of microwave treatment is 20 to 40 minutes, filter, add water to the filter residue, and the ratio of the weight of water to the weight of the filter residue is 8:1. The time is 20 to 40 minutes, filter, combine the filtrates, vacuum concentrate to a clear paste with a relative density of 1.10 to 1.15 at 60°C, add ethanol, the ratio of the weight of ethanol to the weight of the concentrated solution is 3:1, stir and stand for 22 After ~26 hours, filter, and concentrate the filtrate in v...

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating acute upper respiratory tract infection and a production method of the traditional Chinese medicine preparation, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation consists of a honeysuckle flower extract, aqueous extracts of weeping forsythia capsule and baikal skullcap root, and beta cyclodextrin; and the traditional Chinese medicine preparation comprises the following components in parts by weight: 460-540 parts of honeysuckle flower, 460-540 parts of weeping forsythia capsule, 140-185 parts of baikal skullcap root and 30-80 parts of beta cyclodextrin. The traditional Chinese medicine preparation disclosed by the invention is high in medicine stability, less in auxiliary material dosage and wide in application range; by adopting the production method disclosed by the invention, effective components in each medicinal material in the preparation are subjected to distinguished treatment and are refined; and moreover, the production method is simple, has wide market prospects, and is suitable for large-scale production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating acute upper respiratory tract infection and a production method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Acute upper respiratory tract infection (AURTI) is a general term for acute inflammation of the nasal cavity, pharynx or larynx, and is the most common respiratory infectious disease. Patients regardless of age, gender, occupation and region. The disease is not only highly contagious, but also can cause serious complications, so it should be actively prevented and treated. The disease can occur throughout the year, with winter and spring as the high incidence period. It can be transmitted through virus-containing droplets or contaminated hands and utensils. It is mostly sporadic, but it can be popular when the climate changes suddenly. Because there are many types of viruses, the human body's immunity to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K47/40A61P11/00A61P31/12A61P31/16A61P31/04
Inventor 王波
Owner GUANGXI DOUBLE ANT PHARMA
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