The invention discloses a traditional Chinese medicinal preparation for treating acute upper respiratory infection and a preparation method of the traditional Chinese medicinal preparation and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal preparation for treating the acute upper respiratory infection is prepared from extracts of honeysuckle, folium vilicis negundo, evodia lepta, wild chrysanthemum flower, south isatis root and holly root, acetaminophen, chlorpheniramine maleate, caffeine and beta cyclodextrin. The traditional Chinese medicinal preparation for treating the acute upper respiratory infection is based on basic pathogenesis of wind, warmness, heat and toxin, medicines with dispelling, relieving, eliminating and promoting effects are selected and combined for jointly realizing the effects of dispelling wind, relieving symptoms and clearing away heat and toxic materials, and the traditional Chinese medicinal preparation for treating the acute upper respiratory infection is sucrose-free granules and has the advantages of high stability, low dosage of auxiliary materials and wide application range. The preparation method of the traditional Chinese medicinal preparation for treating the acute upper respiratory infection has the advantage that active ingredients in each component of the traditional Chinese medicinal preparation are distinguished, processed and refined; and the preparation method of the traditional Chinese medicinal preparation for treating the acute upper respiratory infection is simple, has a broad market prospect and is applicable to large scale production.