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Andrographolide concentrated liquid and medical application thereof

An andrographolide, concentrated type technology is applied in the field of andrographolide concentrated liquid formulations, can solve the problems of small drug loading, large dosage, large amount of auxiliary materials, etc., achieves reduction in volume and quantity, reduction in packaging volume, The effect of increasing the concentration

Active Publication Date: 2015-06-10
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] The existing marketed dosage forms of andrographolide are tablets, capsules and dripping pills, which generally have the defects of small drug load, large amount of excipients, and large dosage. Up to now, there has been no preparation of andrographolide into a concentrated liquid composition. Fang's research or report

Method used

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  • Andrographolide concentrated liquid and medical application thereof
  • Andrographolide concentrated liquid and medical application thereof
  • Andrographolide concentrated liquid and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation of andrographolide concentrate (the weight ratio of andrographolide to solubilizer is 1:20)

[0039] Andrographolide 20g

[0040] F68 400g

[0041] Absolute ethanol 600mL

[0042] Add sterile water for injection to 1000mL

[0043] Process:

[0044] 1. Measure the prescribed amount of andrographolide in a 2000mL beaker, add the prescribed amount of absolute ethanol, stir magnetically in a 90°C water bath until the drug is completely dissolved, and continue to place it in a 90°C water bath to obtain the andrographolide ethanol solution ,stand-by.

[0045] 2. Weigh the prescription amount F68, add it to the above-mentioned andrographolide ethanol solution, stir magnetically in a water bath at 90°C until the system becomes a uniform solution, add 160mL sterile water for injection to it under stirring, adjust the pH value to 5, and sterilize Add water for injection to 1000mL, and continue to stir for 30min to obtain.

[0046] Preparation Appearan...

Embodiment 2

[0050] Example 2: Preparation of andrographolide liquid preparation (non-concentrated solution) (the weight ratio of andrographolide to solubilizer is the same as that in "Example 1")

[0051] Andrographolide 2g

[0052] F68 40g

[0053] Absolute ethanol 30mL

[0054] Add sterile water for injection to 1000mL

[0055] Process:

[0056] 1. Measure the prescribed amount of andrographolide in a 2000mL beaker, add the prescribed amount of absolute ethanol, stir magnetically in a 90°C water bath until the drug is completely dissolved, and continue to place it in a 90°C water bath to obtain the andrographolide ethanol solution ,stand-by.

[0057] 2. Weigh the prescription amount F68, add it to the above ethanol solution of andrographolide, stir magnetically in a water bath at 90°C until the system is a uniform solution, add 800mL of sterilized water for injection at the same temperature under stirring, and adjust the pH value to 5. Add sterilized water for injection to 1000mL, ...

Embodiment 3

[0060] Example 3: Preparation of andrographolide concentrate (the weight ratio of andrographolide to solubilizer is 1:100)

[0061] Andrographolide 20g

[0062] F68 400g

[0063] Absolute ethanol 600mL

[0064] Add sterile water for injection to 1000mL

[0065] Process: the same as the process in "Example 1".

[0066] Similar to the preparation prepared in "Example 1", the prepared andrographolide concentrate is a clear, slightly viscous liquid.

[0067] Preparation of andrographolide liquid preparation (non-concentrate) (the weight ratio of andrographolide to solubilizer is 1:100)

[0068] Andrographolide 2g

[0069] F68 200g

[0070] Absolute ethanol 30mL

[0071] Add sterile water for injection to 1000mL

[0072] Technology: with the technology in " embodiment 2 ".

[0073] Preparation Appearance:

[0074] Similar to the preparation prepared in "Example 2", the prepared andrographolide liquid preparation was a clear and transparent solution in a water bath at 90°C...

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Abstract

The invention discloses an andrographolide concentrated liquid, which comprises active component andrographolide, a solubilizer, a mixed solvent, an antioxidant and a pH modifier, and is characterized in that the weight ratio of the solubilizer and the andrographolide is (10:1) to (100:1); the concentration of the andrographolide in the concentrated liquid is 5-50mg / mL; the mixed solvent is selected from one or more of ethyl alcohol-water, ethyl alcohol-glycerinum, ethyl alcohol-propylene glycol, tert-butyl alcohol-water, tert-butyl alcohol-glycerinum, tert-butyl alcohol-propylene glycol, propylene glycol-water and propylene glycol-glycerinum. The andrographolide concentrated liquid formula can be applied to oral administration or parenteral administration after being diluted with sterile water for injection, a glucose injection, a 0.9% sodium chloride injection and 0-20% F68 solution, and can also be mixed with a filler and (or) a freeze-drying protecting agent to prepare a powder preparation or a freeze-dried agent by a spray drying or freeze-drying technique.

Description

Technical field: [0001] The invention belongs to the field of pharmaceutical preparations, and discloses a concentrated liquid prescription of andrographolide and its medical application. Background technique: [0002] Andrographolide is a diterpene lactone compound extracted from the plant Andrographis paniculata of the Acanthaceae family. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. It has a special curative effect on upper respiratory tract infection and dysentery, and is known as a natural antibiotic drug. Its pharmacological effects mainly include the following aspects: [0003] (1) Anti-pathogenic microorganism effect [0004] Animal experiments show that both andrographolide and neoandrographolide can inhibit and delay the rise in body temperature caused by pneumococcus or hemolytic streptococcus, but andrographolide has a stronger effect than neoandrographolide. [0005] In vitro experiments show that Androg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K9/00A61K31/365A61P31/04A61P31/12A61P29/00A61P37/04A61P15/04A61P15/18A61P1/16A61P35/00A61P25/20
Inventor 邓意辉程晓波王春玲郭利刚范迪焦姣
Owner SHENYANG PHARMA UNIVERSITY
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